Abstract：
:A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels indicative of anovulation were obtained. In each of these cycles, an absence of the midcycle luteinizing hormone (LH) peak was noted. In an additional 5 cycles with absence of an LH peak, ovulatory steroid patterns were present. The remaining 9 cycles showed gonadotropin and steroid patterns consistent with ovulation. It is concluded that the main contraceptive mechanism is probably other than inhibition of ovulation. Increased viscosity of the cervical mucus is considered a possible means of contraception.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Tredway DR,Mishell DR Jrdoi
10.1016/0010-7824(74)90071-7subject
Has Abstractpub_date
1974-08-01 00:00:00pages
159-69issue
2eissn
0010-7824issn
1879-0518pii
0010-7824(74)90071-7journal_volume
10pub_type
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