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Effects of oral contraceptives containing 50 microgram estrogen on blood coagulation in non-Caucasian women.

Abstract：

:In one of the first longitudinal studies of 163 non-Caucasian women, comprehensive coagulation, fibrinolysis and platelet function tests were performed before and during 24 months of oral contraceptive pill usage containing 50 microgram estrogen. Results of this ongoing study indicate a state of abnormal coagulability with increase in fibrinogen, prothrombin, Factor V and Factor X. There was also a decrease in antithrombin III level. There was a shortening of overall clotting parameters measured by prothrombin time and Kaolin cephalin time. The significance of these changes in the aetiology of thromboembolism is discussed. :163 non-caucasian women in Singapore were studied in the first of a series of longitudinal studies to determine effects of 50-mcg estrogen oral contraceptive (OC) formulations on blood coagulation in these women as compared with effects reported in caucasian women. 2 of the formulations contained hilots interviewed were active in giving hakop 50 mcg of ethinylestradiol. Comprehensive coagulation, fibrinolysis, and platelet function tests were performed during the first 24 months of OC use (all combined formulations). Prothrombin time was significantly reduced only after 12 months of use. The Kaolin cephalin clotting time was reduced and was significant from the 3rd month (P .0005). The thromboelasticity, as shown by thromboelastography, showed no significant alternation in pattern in most patients. There was an increase in fibrinogen level which was significant from the 3rd month (P .025). Factor V and X were significantly increased from the 3rd month (P .0l and P .0l, respectively). And factor II was only significantly increased in the 3rd and 6th month (P .0l) before reverting to pre-OC levels. Factor VII and VIII were not significantly changed, although there was a tendency to rise; at 2 years, the rise was significant for factor VIII. Antithrombin III levels were reduced significantly from the 9th month, and alpha macroglobulin tended to rise, but not significantly. Plasminogen level was significantly increased (P .005). Spontaneous fibrinolytic activity and euglobulin fraction were increased (P .05 for both). Fibrinogen degradation products were unchanged, until after 2 years, when they rose significantly. The number of platelets was significantly increased (P .02) after 9 months, except for a sudden decrease at 24 months. No changes in aggregation or adhesiveness were noted, except for the latter at 24 months.

journal_name

Contraception

journal_title

Contraception

authors

Tsakok FH,Koh S,Ratnam SS

doi

10.1016/0010-7824(80)90015-3

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

505-27

issue

eissn

0010-7824

issn

1879-0518

pii

0010-7824(80)90015-3

journal_volume

pub_type

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Effects of oral contraceptives containing 50 microgram estrogen on blood coagulation in non-Caucasian women.