Abstract：
BACKGROUND:This study was conducted to determine the effects of the monophasic oral contraceptive (OC) containing 30 mcg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) on the nasal respiratory epithelium in premenopausal women. STUDY DESIGN:Fifty premenopausal women participated in the prospective study. Baseline endovaginal ultrasound examination and blood test to measure serum progesterone to confirm an ovulatory cycle were performed. The cytologic changes on the nasal respiratory epithelium were evaluated with the maturation index, performed during the follicular, periovular and luteal phases of the menstrual cycle, and on the sixth cycle of pill intake. RESULTS:The maturation indexes of the nasal smears were higher during both the follicular and periovular phases than during the luteal phase of the menstrual cycle (p<.05). Women on the OC pill had similar changes in the nasal epithelium as those seen during the follicular phase (p NS), and less than the periovular phase (p<.05) and higher than the luteal phase (p<.05). The maturation index of the nasal respiratory epithelium seems to depend on the variation of the ovarian steroids during the menstrual cycle and on the iatrogenic effects of oral contraception. CONCLUSIONS:DRSP+EE seems to provoke cytological changes that are different from previously shown gestodene plus EE.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Caruso S,Serra A,Grillo C,Agnello C,Di Mari L,Cianci Adoi
10.1016/j.contraception.2007.12.010subject
Has Abstractpub_date
2008-05-01 00:00:00pages
344-9issue
5eissn
0010-7824issn
1879-0518pii
S0010-7824(08)00033-4journal_volume
77pub_type
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