Abstract:
BACKGROUND:Experimental evidences suggest that metabolic activation and conversion of oral contraceptive pills (OCPs) to reactive species are responsible for their genotoxicity. The present study was undertaken to investigate the effects of low-dose (LD) OCPs on the activities of erythrocyte antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in OCP consumers. STUDY DESIGN:Enzyme activities were assayed spectrophotometrically in 50 healthy women with normal menstrual cycles who served as the control group and 50 women taking LD OCPs. RESULTS:The pooled data obtained for erythrocyte GPX activity in OCP consumers (50.05 ± 14.9 U/g of Hb) was significantly higher (+15.4%, p = .015) than in the control group (42.33 ± 16.31 U/g of Hb), but the same comparison for SOD activity between the control group (83.46 ± 23.97 U/g of Hb) and women receiving OCPs (81.83 ± 23.97 U/g of Hb) showed an insignificant (-2%, p = .699) decrease. The duration of intake of OCPs beyond 36 months had an effect on the magnitude of the increase (+16.2%) and the decrease (-11%) in GPx and SOD activities, respectively. There was a significant and considerable (not significant) correlation between the activities of GPx (p = .039) and SOD (p = .102) with the duration of OCP consumption, respectively. CONCLUSION:These findings suggested that OCPs may stimulate or reduce the activities of GPx and SOD enzymes, respectively. This may be due to an effect of these pills on bone marrow erythroblast maturation via stimulation or inhibition of the synthesis of new active GPx and SOD molecules or may be a result of the increased frequency of an allele of the GPx and SOD enzymes. It is suggested that these alterations in GPx and SOD activities may be related to their probable protective effects in response to various pathological and physiological properties of OCPs. It seems that probably free radicals produced during metabolism of OCPs provoke the activity of antioxidant enzymes.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Fallah S,Valinejad Sani F,Firoozrai Mdoi
10.1016/j.contraception.2010.07.026subject
Has Abstractpub_date
2011-04-01 00:00:00pages
385-9issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(10)00461-0journal_volume
83pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract:BACKGROUND:Fear of adverse effects on subsequent fertility following reversible contraceptive use is an important concern for some women. STUDY DESIGN:We undertook a comprehensive and objective review of the literature for prospective studies reporting pregnancy rates in women following contraceptive cessation. One-ye...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2011.04.002
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to explore a new three-dimensional, reticular intrauterine device (3-DRIUD) composed of nitinol and silicone rubber and to observe the contraceptive effect of the device in rats. STUDY DESIGN:Two contraceptive experiments were performed. In the first, female rats underwent bilatera...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.10.031
更新日期:2013-07-01 00:00:00
abstract::The use of multiple clips for the occlusion of the Fallopian tubes has been reported in interval laparoscopic sterilization, but the circumstances leading to the performance of the multiple-clip procedure and its effects on safety and efficacy have not been carefully studied. A data set from international multi-center...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(94)90058-2
更新日期:1994-11-01 00:00:00
abstract::The exact role of apoptosis that occurs in human placenta during the early stage of pregnancy remains unknown because of the difficulty in obtaining the intact implantation site. In this study, we used rhesus monkey as an animal model to examine apoptosis occurring in the implantation site at various stages of early p...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00241-4
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volun...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2007.08.006
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Provision of contraception is often linked with physical examination, including clinical breast examination (CBE) and pelvic examination. This review was conducted to evaluate the evidence regarding outcomes among women with and without physical examination prior to initiating hormonal contraceptives. STUDY...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2012.08.010
更新日期:2013-05-01 00:00:00
abstract::New studies linking use of oral contraceptives (OCs) containing a third generation progestogen with venous thromboembolism (VTE) have stirred controversy. Epidemiologists face the task of separating a direct effect of the OC from the confounding effect of a pre-existing factor (e.g., smoking). Only 1-2% of VTE cases...
journal_title:Contraception
pub_type: 评论,社论
doi:10.1016/0010-7824(96)00111-4
更新日期:1996-07-01 00:00:00
abstract::This paper presents a secondary analysis of 3419 Norplant users from 11 countries throughout Asia, Africa and Latin America. The main objective was to identify the menstrual problems associated with a high risk of early discontinuation of Norplant use. Eligible participants were divided into two groups: those who cont...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(03)00040-4
更新日期:2003-05-01 00:00:00
abstract::A pharmaceutical and pharmacokinetic study was carried out on levonorgestrel tablets from two different sources (Hungarian- and Chinese-made). Both preparations contained 0.75 mg levonorgestrel and had been shown to have similar contraceptive efficacy and side effects when used for postcoital contraception. Absorption...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(90)90064-3
更新日期:1990-05-01 00:00:00
abstract::The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(89)90012-7
更新日期:1989-01-01 00:00:00
abstract::The potential use of tamoxifen, a nonsteroidal antiestrogen, as an antifertility agent was studied in the long-tailed macaque (Macaca fascicularis). Twenty-six cycling females were bred, then treated with a single oral dose of tamoxifen (5 mg/kg) (N = 13) or vehicle (N = 13) on day 4 post-ovulation. Serum progesterone...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(93)90047-b
更新日期:1993-03-01 00:00:00
abstract::Cancer incidence in countries representative of three patterns of reproductive cancer and age-specific mortality was used to estimate the effect of oral contraceptive use on the lifetime probability of reproductive cancer under three sets of assumptions about the effects of oral contraceptives. Under the set of assump...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(92)90043-s
更新日期:1992-02-01 00:00:00
abstract::The importance of a simple, rapid and highly sensitive test for the diagnosis of early pregnancy cannot be overemphasized. In the present times when newer delivery systems of contraceptive agents and menstrual regulation procedures are increasingly used for fertility regulation, it is inevitable that confirmation of e...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(78)90039-2
更新日期:1978-11-01 00:00:00
abstract::The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(85)90108-8
更新日期:1985-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to measure the accessibility to purchase oral and transdermal contraceptives over the Internet for low- and high-risk individuals. METHODS:The Internet was used to search for and order both oral and transdermal contraceptives. Using the "Google" search engine to locate online pha...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.10.001
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To describe the efficacy, safety, and acceptability of medical abortion in the late first trimester. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of medical abortion at gestational ages (>63 to≤84 days gestation). We sought articles that compar...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.11.002
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:The goal of this paper is to review the imaging methods required for localizing nonpalpable Implanontrade mark. METHOD:Different localization methods for nonpalpable Implanon rods are summarized, and clinical guidance is provided as to how best to localize such implants. RESULTS:In the great majority of cases...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2005.10.009
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Combined oral contraceptive (COC) formulations with 20 mcg ethinyl estradiol (EE) have a greater incidence of ovarian hormone production and follicular development, which can be managed by shortening the number of hormone-free days per COC cycle. This study evaluates differences in follicular development dur...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2008.10.005
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Whether contraception affects health-related quality of life (HRQoL) is unclear. STUDY DESIGN:We conducted a cross-sectional analysis of routine intake data collected from women aged 18-50 years, including the RAND-36 (Research and Development Corporation) measure of HRQoL, pregnancy intentions and recent c...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2011.08.004
更新日期:2012-03-01 00:00:00
abstract::The objectives of this study were to define the "normal" position of the T-shaped intrauterine device (IUD) in the endometrial cavity, using transvaginal ultrasound, and to compare the IUD's position in women with and without complaints of bleeding and/or pain. Vaginal ultrasound was carried out in women who had used ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(97)00072-3
更新日期:1997-07-01 00:00:00
abstract::Gossypol has been shown to inhibit steroidogenesis in leydig cells. This study examined the mechanism of this action by investigating the effect of gossypol on leydig cell hCG receptor binding, adenylate cyclase activity and cyclic AMP production in leydig cells. Gossypol had no effect on hCG binding to cell membranes...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(86)80019-1
更新日期:1986-12-01 00:00:00
abstract:OBJECTIVES:The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN:We administered a nationally-representative, ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.09.010
更新日期:2018-03-01 00:00:00
abstract::The study of a modified minilaparotomy technique of interval female sterilization is reported. The modified minilaparotomy technique of interval female sterilization is performed under local anesthesia using the Ramathibodi uterine manipulator, bivalve speculum, and a low midline incision. Sixty cases were treated wit...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(97)00043-7
更新日期:1997-06-01 00:00:00
abstract::Saponins isolated from Sapindus mukorossi have potent spermicidal activity. Morphological changes in human ejaculated spermatozoa after exposure to these saponins were evaluated under Scanning Electron Microscope. The minimum effective concentration (0.05% in spot test) did not affect the surface topography after expo...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90111-x
更新日期:1989-05-01 00:00:00
abstract::Roussel Uclaf in partnership with the INSERM unit of Prof. E.E. Baulieu first discovered mifepristone (RU486) as part of a large research program on steroidal compounds with antihormone properties. Exhibiting a strong affinity to the progesterone and the glucocorticoid receptors, mifepristone exerted competitive antag...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(03)00171-9
更新日期:2003-12-01 00:00:00
abstract::An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(82)90146-9
更新日期:1982-11-01 00:00:00
abstract:INTRODUCTION:The relationship between the source of sexual information and adolescent sexual behavior is not well understood. MATERIALS AND METHODS:As part of a larger study, 892 sexually active female adolescents between 15 and 18 years of age completed a paper-and-pencil survey which assessed discussions about sexua...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.08.014
更新日期:2006-03-01 00:00:00
abstract::The present study was aimed to evaluate iron metabolism in active and healthy adult women having taken oral contraceptives (OC) long-term. Mean dietary iron intake in age-matched control and experimental groups was adequate. Serum ferritin used as a marker for body iron stores was marginal in both groups underlying a ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(92)90005-e
更新日期:1992-09-01 00:00:00
abstract::The treatment outcomes of 956 women undergoing second trimester termination of pregnancy with mifepristone and gemeprost were studied. The median gestational age was 16 weeks (range: 12-24 weeks). All women were treated with 200 mg mifepristone orally, followed 36 h later with 1 mg vaginal gemeprost administered every...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00219-0
更新日期:2001-07-01 00:00:00
abstract::A number of case-control studies published in recent years have shown an apparent increase in the risk of venous thromboembolism (VTE) associated with the use of third-generation oral contraceptives (OCs) compared with second-generation OCs. However, it is thought that these studies were subject to a number of biases ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/s0010-7824(00)00146-3
更新日期:2000-08-01 00:00:00