Abstract:
:Gossypol has been shown to inhibit steroidogenesis in leydig cells. This study examined the mechanism of this action by investigating the effect of gossypol on leydig cell hCG receptor binding, adenylate cyclase activity and cyclic AMP production in leydig cells. Gossypol had no effect on hCG binding to cell membranes but inhibited LH-stimulated cyclic AMP production in whole purified leydig cells. It also reduced the stimulation caused by LH, Gpp(NH)p, forskolin and fluoride in membranes from leydig cells and also from liver. It is therefore possible that gossypol affects cyclic AMP production at the level of ATP conversion to cyclic AMP, although effects on the G-protein and catalytic subunit cannot be ruled out.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Pearce S,Sufi SB,O'Shaughnessy PJ,Donaldson A,Jeffcoate SLdoi
10.1016/s0010-7824(86)80019-1subject
Has Abstractpub_date
1986-12-01 00:00:00pages
639-46issue
6eissn
0010-7824issn
1879-0518pii
S0010-7824(86)80019-1journal_volume
34pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract::In 1991, the source of public sector condom supplies in an African country changed from USAID to WHO. Following a complaint, the two types of condoms were sampled and compared. Laboratory tests indicated that the new-style condoms were of adequate quality, but a number of differences were noted between the two types. ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(95)00183-b
更新日期:1995-10-01 00:00:00
abstract::An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(82)90146-9
更新日期:1982-11-01 00:00:00
abstract::To describe surface abnormalities found by scanning electron microscopy of non-lubricated latex condoms, thirty samples of 15 condoms were photographed at low (26-94x), medium (240-940x) and high (> 1000x) magnification. Each sample was initially scanned at low magnification to determine the presence and location of s...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(95)00259-6
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:We sought to determine whether there are differences in subject's motivation to participate in hormonal and barrier method contraceptive efficacy studies. STUDY DESIGN:All women presenting for screening appointments for either barrier or hormonal contraceptive efficacy trials were asked to complete a survey...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2009.03.015
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The use of ultrasound (US) is common in some settings before an abortion procedure. However, its positive effect on the safety or efficacy (ability to complete abortion) of the procedure has not been established. Our aim was to determine whether the use of pre-procedure US improves safety and/or efficacy of ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.06.014
更新日期:2011-01-01 00:00:00
abstract::The effects of two triphasic oral contraceptives containing the same amount of ethinylestradiol (EE) in combination with levonorgestrel (LNG) or gestodene (GES), respectively, on lipid metabolism and coagulation were studied. Serum concentrations of GES and LNG were determined at the same time. Thirty-three healthy wo...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(89)90070-x
更新日期:1989-12-01 00:00:00
abstract::Deeply inserted, nonpalpable contraceptive implants can often be removed easily using 6-8 cm3 of 1% lidocaine and a single 1 cm incision. There is no need for suturing of the incision. The location of nonpalpable implants not retrieved by this procedure can be determined by a plain, soft tissue x-ray (standard AP and ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(96)00004-2
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The Affordable Care Act (ACA) will expand health care coverage to low-income Americans. Contraception services are a mandated component of ACA plans. STUDY DESIGN:A decision-analytic model was developed to compare the costs and outcomes of the current versus the proposed plan for contraceptive coverage (Fed...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.06.009
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The study was conducted to characterize the changes in bleeding pattern over time in women receiving the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding (HMB). The reduction in menstrual blood loss volume has been well documented elsewhere. STUDY DESIGN:Post hoc pooled an...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2012.08.022
更新日期:2013-01-01 00:00:00
abstract::Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm o...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0010-7824(95)00263-4
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine the effects of the monophasic oral contraceptive (OC) containing 30 mcg ethinylestradiol (EE) and 3 mg drospirenone (DRSP) on the nasal respiratory epithelium in premenopausal women. STUDY DESIGN:Fifty premenopausal women participated in the prospective study. Baseline ...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2007.12.010
更新日期:2008-05-01 00:00:00
abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90077-1
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to explore a new three-dimensional, reticular intrauterine device (3-DRIUD) composed of nitinol and silicone rubber and to observe the contraceptive effect of the device in rats. STUDY DESIGN:Two contraceptive experiments were performed. In the first, female rats underwent bilatera...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.10.031
更新日期:2013-07-01 00:00:00
abstract::The morphology and the related composition of T-type intrauterine devices (IUDs) made of gold-plated copper were studied in relation to patient complaints. The removed IUDs were examined without pretreatment by scanning electron microscopy and energy dispersive x-ray spectroscopy. Besides the previously found incrusta...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.03.006
更新日期:2004-08-01 00:00:00
abstract::Effect of antiestrogen ormeloxifene on progesterone-induced development of giant mitochondria in uterine glandular epithelial cells in ovariectomized adult Sprague-Dawley rats was investigated. Antiestrogen tamoxifen and antiprogestin onapristone were used for comparison. Well-formed giant mitochondria were observed i...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(96)00197-7
更新日期:1996-10-01 00:00:00
abstract::Numerous non-comparative clinical trials of the Dalkon Shield appear to provide ample evidence that the Dalkon Shield was an effective IUD; they seem to yield little evidence that it was a dangerous device, nor markedly different from its contemporaries. Equating the performance of the Dalkon Shield IUD to that of the...
journal_title:Contraception
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1016/0010-7824(93)90060-k
更新日期:1993-07-01 00:00:00
abstract::The effects of cyproterone acetate (CPA), administered orally in dos es of either 10 or 20 mg/day for 26 weeks, were studied in 15 healthy male volunteers. During treatment, there was a decrease in sperm density and in normal-shaped sperm and an increase in pathological and immature forms, an increase in dead spermat...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(76)90081-0
更新日期:1976-08-01 00:00:00
abstract::New studies linking use of oral contraceptives (OCs) containing a third generation progestogen with venous thromboembolism (VTE) have stirred controversy. Epidemiologists face the task of separating a direct effect of the OC from the confounding effect of a pre-existing factor (e.g., smoking). Only 1-2% of VTE cases...
journal_title:Contraception
pub_type: 评论,社论
doi:10.1016/0010-7824(96)00111-4
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Women ages 35 years and older have the greatest proportion of contraceptive nonuse and unintended pregnancies ending in abortion. STUDY DESIGN:We conducted a population-based case-control study among women ages 35-44 years at risk of unwanted pregnancy using the National Survey of Family Growth (NSFG) data ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2009.12.013
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Nurses play an integral role in intrapartum and postpartum patient education. This exploratory study aims to assess the attitudes, knowledge, and practices of labor and delivery and postpartum nurses regarding contraception and evaluate for changes in these measures 1 year after an institutional initiative a...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2018.01.017
更新日期:2018-05-01 00:00:00
abstract::A multinational comparative trial of three IUDs (Copper 7, Lippes loop size D and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in six centres. A total of 841 women entered the study. As the predetermined termination indices for expulsions were exceeded at six months ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(80)90112-2
更新日期:1980-07-01 00:00:00
abstract::Because RU 486 synergizes with anordrin and its dihydroxylated metabolite to terminate established pregnancy in the rat and rabbit, the interactions of these agents were studied at two days postcoitally in the rat. RU 486 at a dose of 4 mg/kg did not prevent pregnancy when the animals were killed 12 days post insemina...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(93)90038-9
更新日期:1993-04-01 00:00:00
abstract::Conventional oral contraceptive (OC) starting instructions require waiting until menses to begin the OC. The conventional approach requires detailed patient education about when to begin and also may require the use of less effective or less acceptable interim contraceptive protection until menses. At our urban family...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00351-7
更新日期:2002-09-01 00:00:00
abstract::A group of 120 women with gestations from 64 to 84 days received 800 micrograms of vaginal misoprostol every 24 h for a maximum of three doses without performing postexpulsion systematic preventive curettage. Outcome measures included successful abortion (complete abortion without requiring a surgical procedure), side...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(98)00037-7
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Pharmacies are important sites for access to health information and medications in Mexico. Most workers are not trained in health issues and may provide inaccurate information to consumers. Misoprostol is used by women throughout Mexico for early abortion and often is purchased from pharmacies. This study ai...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2008.12.011
更新日期:2009-06-01 00:00:00
abstract::Condoms from five manufacturers were subjected to controlled exposures of heat, humidity, and air and to different natural environments in five countries. Under aerobic conditions (condoms in permeable packages or unpackaged), stress properties declined. The relationship between rate of decline as a function of temper...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(96)00041-8
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVES:We wanted to explore the effects of two different low doses (0.5μM and 0.05μM) of mifepristone, exposed during the receptive period, on the human embryo implantation process, using a well-established three-dimensional in vitro cell culture model, specifically developed to study this process. METHODS:An in v...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2016.03.009
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Most of the sexually transmitted infection prevention programs fail to attend to the relationship type of individuals at first sexual intercourse and how it influences contraceptive behavior. STUDY DESIGN:A national sample of adolescents (3084 females and 2745 for males) was analyzed to determine the associ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.09.030
更新日期:2013-06-01 00:00:00
abstract::The objectives of this study were to define the "normal" position of the T-shaped intrauterine device (IUD) in the endometrial cavity, using transvaginal ultrasound, and to compare the IUD's position in women with and without complaints of bleeding and/or pain. Vaginal ultrasound was carried out in women who had used ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(97)00072-3
更新日期:1997-07-01 00:00:00
abstract::The objective of the study was to assess the efficacy of cervical preparation with misoprostol or laminaria suction abortion up to 18 weeks gestation. The study was conducted among a consecutive case series of patients presenting for dilatation and evacuation at a single center. Cervical preparation was effected by ei...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00306-2
更新日期:2002-06-01 00:00:00