Abstract:
:A number of case-control studies published in recent years have shown an apparent increase in the risk of venous thromboembolism (VTE) associated with the use of third-generation oral contraceptives (OCs) compared with second-generation OCs. However, it is thought that these studies were subject to a number of biases that would have increased the risk estimates for third-generation OCs while lowering those for second-generation preparations. Data on the risk of ischemic stroke and myocardial infarction (MI) show no such difference between generations of OCs, with a statistically significant reduction in the risk of acute MI from first- to third-generation in one major study. Available results indicate that there is no significant increase in the risk of ischemic stroke or acute MI associated with the use of low-dose estrogen OCs in young women who are properly screened before use, and who have no pre-existing cardiovascular risk factors, such as smoking and hypertension, for these conditions. These findings should be taken into account when interpreting the results of studies on the risk of VTE in women taking combined OCs.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Heinemann LAdoi
10.1016/s0010-7824(00)00146-3subject
Has Abstractpub_date
2000-08-01 00:00:00pages
29S-36S; discussion 37S-38Sissue
2 Suppleissn
0010-7824issn
1879-0518pii
S0010782400001463journal_volume
62pub_type
杂志文章,评审相关文献
CONTRACEPTION文献大全abstract::Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mi...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(88)90102-3
更新日期:1988-09-01 00:00:00
abstract::The aim of this study was to compare contraceptive reliability, cycle control, and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol (EE2) and 75 micrograms gestodene (GSD), with a reference preparation containing a similar dose of gestodene but in combination with 30 micrograms ethinylestra...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0010-7824(97)00025-5
更新日期:1997-03-01 00:00:00
abstract::Sulprostone was given intramuscularly in two dose schedules of 0.5 mg at 4 hourly intervals for 8 doses and 1.0 mg at 8-hour intervals for 4 doses to 56 women in the 12th-20th week of gestation coming for termination of pregnancy. Forty-nine of them aborted within the 30-hour observation period, giving a success rate ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(82)90028-2
更新日期:1982-02-01 00:00:00
abstract::Blood pyrodoxine hydrochloride (vitamin-B6) concentration was determined in 50 women using combined oral contraceptives (OCs), 24 women who received an intramuscular injection of 150 mg medroxyprogesterone acetate (MPA) every 12 weeks, and in 14 women who used an intrauterine device (IUD) at the out-patient contracep...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(74)90078-x
更新日期:1974-04-01 00:00:00
abstract:BACKGROUND:Potential barriers to intrauterine device (IUD) use include provider concern about difficult insertion, particularly for nulliparous women. OBJECTIVE:This study aims to evaluate the evidence on the effectiveness of medications to ease IUD insertion on provider outcomes (i.e., ease of insertion, need for adj...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2016.06.014
更新日期:2016-12-01 00:00:00
abstract::Because RU 486 synergizes with anordrin and its dihydroxylated metabolite to terminate established pregnancy in the rat and rabbit, the interactions of these agents were studied at two days postcoitally in the rat. RU 486 at a dose of 4 mg/kg did not prevent pregnancy when the animals were killed 12 days post insemina...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(93)90038-9
更新日期:1993-04-01 00:00:00
abstract::The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 x...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00406-7
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:We examine the lifetime and past-year prevalence and circumstances of unprotected intercourse among members of the Society of Family Planning (SFP), a professional reproductive health organization in the United States. STUDY DESIGN:We invited the membership of SFP (n=477) via email to participate in an anon...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.04.004
更新日期:2015-07-01 00:00:00
abstract::A study has been made of the serum 25-hydroxycholecalciferol (25-HCC) levels in six groups of women. Significant differences were found between the one pregnant group and the two reference groups as well as between the one pregnant group and two of the three groups using oral contraceptives. No significant differences...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90029-9
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.01.001
更新日期:2019-05-01 00:00:00
abstract::The overall and renal toxicity of racemic gossypol acetic acid was assessed in 6 mongrel dogs. Oral racemic gossypol acetic acid was given orally at doses increasing from 10 to 40 mg/d for a total of 6 weeks in 3 female dogs and from 40 to 80 mg/d for a total of 4 weeks in 3 male dogs. The animals were then sacrificed...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(88)90127-8
更新日期:1988-02-01 00:00:00
abstract::This double-blind randomized control study was conducted to evaluate whether a nonsteroidal anti-inflammatory drug (NSAID) could act as an effective pain control method during first trimester suction abortion, and whether co-treatment of NSAID with misoprostol will decrease the efficacy of the cervical ripening effect...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(02)00437-7
更新日期:2003-02-01 00:00:00
abstract::The importance of a simple, rapid and highly sensitive test for the diagnosis of early pregnancy cannot be overemphasized. In the present times when newer delivery systems of contraceptive agents and menstrual regulation procedures are increasingly used for fertility regulation, it is inevitable that confirmation of e...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(78)90039-2
更新日期:1978-11-01 00:00:00
abstract:OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.06.004
更新日期:2020-10-01 00:00:00
abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90107-i
更新日期:1993-01-01 00:00:00
abstract::A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1997-10-01 00:00:00
abstract::The changes in haemostasis during oral contraception are related to the ethinylestradiol dose present in the formulation taken by the patient. An open, randomized longitudinal study was performed to evaluate and compare the effects that low-dose oral contraceptives (OCs) containing different doses of ethinylestradiol ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(91)90123-w
更新日期:1991-01-01 00:00:00
abstract::The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the ma...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(88)90008-x
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Music has served as an auxiliary analgesic in perioperative settings. This study evaluates the impact of intraoperative music added to routine pain control measures during first trimester surgical abortion. STUDY DESIGN:We analyzed data from 101 women randomized to undergo abortion with routine pain control...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.11.017
更新日期:2012-08-01 00:00:00
abstract::The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(78)90066-5
更新日期:1978-02-01 00:00:00
abstract:OBJECTIVE:To assess the cost-effectiveness of self-injected subcutaneous depot medroxyprogesterone acetate (DMPA-SC) compared to health-worker-administered intramuscular DMPA (DMPA-IM) in Uganda. STUDY DESIGN:We developed a decision-tree model with a 12-month time horizon for a hypothetical cohort of approximately 1 m...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.07.137
更新日期:2018-11-01 00:00:00
abstract::Deeply inserted, nonpalpable contraceptive implants can often be removed easily using 6-8 cm3 of 1% lidocaine and a single 1 cm incision. There is no need for suturing of the incision. The location of nonpalpable implants not retrieved by this procedure can be determined by a plain, soft tissue x-ray (standard AP and ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(96)00004-2
更新日期:1996-03-01 00:00:00
abstract:PURPOSE:Quantitative evaluation of properties of bromhexine (B) for expression of uterine proteins in ovariectomized (OVX) and pregnant rats. MATERIALS AND METHODS:Expression of proteins through SDS-PAGE, along with incorporation of glycosidic moieties, was conducted in pregnant and OVX rats under B influence. These f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.11.006
更新日期:2006-06-01 00:00:00
abstract::The effect of 2 long-acting injectables on the plasma protein-bound carbohydrate components and serumucoid when taken for different periods, was illustrated in 100 women of childbearing age. 40 acted as controls, 30 took depot-medroxyprogesterone acetate (DMPA), and 30 took norethisterone enanthate (NET-EN). DMPA wa...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(77)90051-8
更新日期:1977-10-01 00:00:00
abstract::Chemical immersion tests, electrochemical methods and atomic absorption spectrometry were employed to investigate the corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy (SMA) in simulated uterine fluid. The effect of pH on corrosion rate and corrosion potential was also investigated. The results indicated th...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.04.006
更新日期:2005-09-01 00:00:00
abstract::A report that serum prolactin concentrations were almost doubled by the use of copper IUDs led us to study the effect of both copper and inert IUDs. We studied 105 normal women in whom all other prolactinergic factors had been excluded; 25 of them were using copper IUDs, 25 were using inert IUDs and there were 55 cont...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(79)90049-0
更新日期:1979-11-01 00:00:00
abstract:BACKGROUND:Emergency contraception (EC) does not always work. Clinicians should be aware of potential risk factors for EC failure. STUDY DESIGN:Data from a meta-analysis of two randomized controlled trials comparing the efficacy of ulipristal acetate (UPA) with levonorgestrel were analyzed to identify factors associat...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2011.02.009
更新日期:2011-10-01 00:00:00
abstract::Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90020-3
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2010.04.013
更新日期:2010-10-01 00:00:00
abstract::The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(89)90012-7
更新日期:1989-01-01 00:00:00