Emerging evidence on oral contraceptives and arterial disease.

Abstract:

:A number of case-control studies published in recent years have shown an apparent increase in the risk of venous thromboembolism (VTE) associated with the use of third-generation oral contraceptives (OCs) compared with second-generation OCs. However, it is thought that these studies were subject to a number of biases that would have increased the risk estimates for third-generation OCs while lowering those for second-generation preparations. Data on the risk of ischemic stroke and myocardial infarction (MI) show no such difference between generations of OCs, with a statistically significant reduction in the risk of acute MI from first- to third-generation in one major study. Available results indicate that there is no significant increase in the risk of ischemic stroke or acute MI associated with the use of low-dose estrogen OCs in young women who are properly screened before use, and who have no pre-existing cardiovascular risk factors, such as smoking and hypertension, for these conditions. These findings should be taken into account when interpreting the results of studies on the risk of VTE in women taking combined OCs.

journal_name

Contraception

journal_title

Contraception

authors

Heinemann LA

doi

10.1016/s0010-7824(00)00146-3

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

29S-36S; discussion 37S-38S

issue

2 Suppl

eissn

0010-7824

issn

1879-0518

pii

S0010782400001463

journal_volume

62

pub_type

杂志文章,评审
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    abstract::Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(88)90102-3

    authors: Rådestad A,Christensen NJ,Strömberg L

    更新日期:1988-09-01 00:00:00

  • A twelve-month comparative clinical investigation of two low-dose oral contraceptives containing 20 micrograms ethinylestradiol/75 micrograms gestodene and 30 micrograms ethinylestradiol/75 micrograms gestodene, with respect to efficacy, cycle control, an

    abstract::The aim of this study was to compare contraceptive reliability, cycle control, and tolerance of an oral contraceptive containing 20 micrograms ethinylestradiol (EE2) and 75 micrograms gestodene (GSD), with a reference preparation containing a similar dose of gestodene but in combination with 30 micrograms ethinylestra...

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    authors: Endrikat J,Müller U,Düsterberg B

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    doi:10.1016/0010-7824(82)90028-2

    authors: Ranjan V,Hingorani V,Kinra G,Agarwal N,Pande Y

    更新日期:1982-02-01 00:00:00

  • Disturbance of tryptophan metabolism and its correction during hormonal contraception.

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    pub_type: 杂志文章

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    authors: Bennink HJ,Schreurs WH

    更新日期:1974-04-01 00:00:00

  • Medications to ease intrauterine device insertion: a systematic review.

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    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2016.06.014

    authors: Zapata LB,Jatlaoui TC,Marchbanks PA,Curtis KM

    更新日期:2016-12-01 00:00:00

  • Postcoital use of anordrin and RU 486 for prevention of implantation in the rat.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(93)90038-9

    authors: Chang CC,Wang WC,Bardin CW

    更新日期:1993-04-01 00:00:00

  • Use of cauda epididymis extract as immunocontraceptive.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00406-7

    authors: Risvanli A,Aydin M,Kaygusuzoglu E,Bulut H,Apaydin AM,Timurkan H

    更新日期:2002-12-01 00:00:00

  • Do as we say, not as we do: experiences of unprotected intercourse reported by members of the Society of Family Planning.

    abstract:OBJECTIVES:We examine the lifetime and past-year prevalence and circumstances of unprotected intercourse among members of the Society of Family Planning (SFP), a professional reproductive health organization in the United States. STUDY DESIGN:We invited the membership of SFP (n=477) via email to participate in an anon...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.04.004

    authors: Aiken AR,Trussell J

    更新日期:2015-07-01 00:00:00

  • Serum 25-hydroxycholecalciferol levels in women using oral contraceptives.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(81)90029-9

    authors: Schreurs WH,van Rijn HJ,van den Berg H

    更新日期:1981-04-01 00:00:00

  • Rebound of medication abortion in Texas following updated mifepristone label.

    abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.01.001

    authors: Baum SE,White K,Hopkins K,Potter JE,Grossman D

    更新日期:2019-05-01 00:00:00

  • Effects of gossypol on the kidney with special emphasis on potassium (K) excretion.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(88)90127-8

    authors: van Ypersele de Strihou C,Dieu JP,Marbaix E

    更新日期:1988-02-01 00:00:00

  • A study of co-treatment of nonsteroidal anti-inflammatory drugs (NSAIDs) with misoprostol for cervical priming before suction termination of first trimester pregnancy.

    abstract::This double-blind randomized control study was conducted to evaluate whether a nonsteroidal anti-inflammatory drug (NSAID) could act as an effective pain control method during first trimester suction abortion, and whether co-treatment of NSAID with misoprostol will decrease the efficacy of the cervical ripening effect...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(02)00437-7

    authors: Li CF,Wong CY,Chan CP,Ho PC

    更新日期:2003-02-01 00:00:00

  • Use of a radioreceptor test for HCG in women practicing contraception.

    abstract::The importance of a simple, rapid and highly sensitive test for the diagnosis of early pregnancy cannot be overemphasized. In the present times when newer delivery systems of contraceptive agents and menstrual regulation procedures are increasingly used for fertility regulation, it is inevitable that confirmation of e...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(78)90039-2

    authors: Shahani SM,Kulkarni PP,Patel KL

    更新日期:1978-11-01 00:00:00

  • Progestin-only pill use over 6 months postpartum.

    abstract:OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...

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    doi:10.1016/j.contraception.2020.06.004

    authors: Uhm S,Garcia-Ruiz N,Creinin MD,Blanton A,Chen MJ

    更新日期:2020-10-01 00:00:00

  • Four-year experience in a randomized study of the Gyne T 380 Slimline and the Standard Gyne T 380 intrauterine copper devices.

    abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(93)90107-i

    authors: Sivin I,Diaz J,Alvarez F,Brache V,Diaz S,Pavez M,Stern J

    更新日期:1993-01-01 00:00:00

  • Comparative study of the effects of two once-a-month injectable steroidal contraceptives (Mesigyna and Cyclofem) on lipid and lipoprotein metabolism. United Nations Development Programme/United Nations Population Fund/World Health Organization/World Bank,

    abstract::A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors:

    更新日期:1997-10-01 00:00:00

  • A comparative study on the effects of a monophasic pill containing desogestrel plus 20 micrograms ethinylestradiol, a triphasic combination containing levonorgestrel and a monophasic combination containing gestodene on coagulatory factors.

    abstract::The changes in haemostasis during oral contraception are related to the ethinylestradiol dose present in the formulation taken by the patient. An open, randomized longitudinal study was performed to evaluate and compare the effects that low-dose oral contraceptives (OCs) containing different doses of ethinylestradiol ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(91)90123-w

    authors: Melis GB,Fruzzetti F,Nicoletti I,Ricci C,Lammers P,Atsma WJ,Fioretti P

    更新日期:1991-01-01 00:00:00

  • Prazosin, an adrenergic blocking agent inadequate as male contraceptive pill.

    abstract::The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the ma...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(88)90008-x

    authors: Kjaergaard N,Kjaergaard B,Lauritsen JG

    更新日期:1988-06-01 00:00:00

  • Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.

    abstract:BACKGROUND:Music has served as an auxiliary analgesic in perioperative settings. This study evaluates the impact of intraoperative music added to routine pain control measures during first trimester surgical abortion. STUDY DESIGN:We analyzed data from 101 women randomized to undergo abortion with routine pain control...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2011.11.017

    authors: Guerrero JM,Castaño PM,Schmidt EO,Rosario L,Westhoff CL

    更新日期:2012-08-01 00:00:00

  • Endometrial histology and progesterone levels in women using norethindrone acetate implants for contraception.

    abstract::The effect of a single implant-D containing 40 mg of norethindrone acetate on the endometrium and serum progesterone, and its mode of contraceptive action was investigated. 20 women aged 20-40 (parity 1-5) had used implant-D for periods of 7-27 months. Endometrial biopsies and peripheral venous bloods were collected...

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(78)90066-5

    authors: Takkar D,Jeyaseelan S,Kinra G,Laumas KR,Hingorani V

    更新日期:1978-02-01 00:00:00

  • Is contraceptive self-injection cost-effective compared to contraceptive injections from facility-based health workers? Evidence from Uganda.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.07.137

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    更新日期:2018-11-01 00:00:00

  • Removal of deeply inserted, nonpalpable levonorgestrel (Norplant) implants.

    abstract::Deeply inserted, nonpalpable contraceptive implants can often be removed easily using 6-8 cm3 of 1% lidocaine and a single 1 cm incision. There is no need for suturing of the incision. The location of nonpalpable implants not retrieved by this procedure can be determined by a plain, soft tissue x-ray (standard AP and ...

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(96)00004-2

    authors: Sarma SP,Wamsher JG,Whitlock SW

    更新日期:1996-03-01 00:00:00

  • Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat.

    abstract:PURPOSE:Quantitative evaluation of properties of bromhexine (B) for expression of uterine proteins in ovariectomized (OVX) and pregnant rats. MATERIALS AND METHODS:Expression of proteins through SDS-PAGE, along with incorporation of glycosidic moieties, was conducted in pregnant and OVX rats under B influence. These f...

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.11.006

    authors: Singh N,Malaviya B

    更新日期:2006-06-01 00:00:00

  • Serium protein-bound carbohydrate and seromucoid levels during long-acting progestational contraceptive therapy.

    abstract::The effect of 2 long-acting injectables on the plasma protein-bound carbohydrate components and serumucoid when taken for different periods, was illustrated in 100 women of childbearing age. 40 acted as controls, 30 took depot-medroxyprogesterone acetate (DMPA), and 30 took norethisterone enanthate (NET-EN). DMPA wa...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(77)90051-8

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    更新日期:1977-10-01 00:00:00

  • Corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy in simulated uterine fluid.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.04.006

    authors: Chen B,Liang C,Fu D,Ren D

    更新日期:2005-09-01 00:00:00

  • Serum prolactin concentrations related to copper or inert intrauterine devices (IUDs) in women.

    abstract::A report that serum prolactin concentrations were almost doubled by the use of copper IUDs led us to study the effect of both copper and inert IUDs. We studied 105 normal women in whom all other prolactinergic factors had been excluded; 25 of them were using copper IUDs, 25 were using inert IUDs and there were 55 cont...

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(79)90049-0

    authors: Ransom WT,Chapman RS,Hull MG

    更新日期:1979-11-01 00:00:00

  • Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.02.009

    authors: Glasier A,Cameron ST,Blithe D,Scherrer B,Mathe H,Levy D,Gainer E,Ulmann A

    更新日期:2011-10-01 00:00:00

  • Postabortal contraception with norethisterone enanthate injections.

    abstract::Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90020-3

    authors: Lähteenmäki P,Toivonen J,Lähteenmäki PL

    更新日期:1983-06-01 00:00:00

  • Endometrial safety of a novel monophasic combined oral contraceptive containing 0.02 mg ethinylestradiol and 2 mg chlormadinone acetate administered in a 24/4-day regimen over six cycles.

    abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...

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    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.04.013

    authors: Rabe T,Hartschuh E,Wahlstrom T,Höschen K,König S

    更新日期:2010-10-01 00:00:00

  • Transdermal delivery of steroids.

    abstract::The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...

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    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(89)90012-7

    authors: Sitruk-Ware R

    更新日期:1989-01-01 00:00:00