Abstract：
:A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357 volunteers from four centers (Hangzhou, Havana, Jakarta, and Shanghai) were monitored during one pretreatment cycle, the third and ninth injection intervals, and during one post-treatment cycle, approximately 3 months after the 9-month period of treatment was completed. With both preparations, changes were observed at 3 months of use, remained essentially unchanged during treatment, and returned to pretreatment levels after discontinuation of use. With Mesigyna, changes consisted mostly of decreases in high density lipoprotein cholesterol (HDL-C, -10%), apolipoprotein AI (-9%), and triglycerides (-15%). With Cyclofem, changes were even smaller. With both, variations in lipid levels mirrored closely the pharmacokinetics of each preparation and the biphasic nature of the injection intervals.
journal_name
Contraceptionjournal_title
Contraceptionauthors
subject
Has Abstractpub_date
1997-10-01 00:00:00pages
193-207issue
4eissn
0010-7824issn
1879-0518pii
S001078249700139Xjournal_volume
56pub_type
临床试验,杂志文章,多中心研究,随机对照试验相关文献
CONTRACEPTION文献大全abstract：:Plasma 1-norgestrel (1-Ng) levels after administration of a common oral contraceptive in fertile women (mean age 29 +/- 5 yrs) with mild ulcerative colitis before or after proctocolectomy with a conventional ileostomy or a continent ileostomy reservoir were determined and compared to those of a group of healthy volunt...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(85)90034-4
更新日期：1985-02-01 00:00:00
abstract：:There is a global need for an ideal method of male contraception. However, the development of male contraceptives has not been well successful. Research on sperm-specific ion channels, especially the recent advance obtained from electrophysiological studies, has emphasized the conception that those channels are target...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2013.06.002
更新日期：2013-10-01 00:00:00
abstract：:The importance of a simple, rapid and highly sensitive test for the diagnosis of early pregnancy cannot be overemphasized. In the present times when newer delivery systems of contraceptive agents and menstrual regulation procedures are increasingly used for fertility regulation, it is inevitable that confirmation of e...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(78)90039-2
更新日期：1978-11-01 00:00:00
abstract：:Experiments were conducted to determine whether oral administration of a water extract of P. dodecandra had significant effects on reproduction in mice. The work is based on earlier reports in this journal that butanol extracts of the berries of this plant had spermatocidal properties in vitro and blastocidal activity...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(87)80006-9
更新日期：1987-02-01 00:00:00
abstract：BACKGROUND:Incarcerated women have had limited access to health care prior to their arrest. Although their incarceration presents an opportunity to provide them with health care, their reproductive health needs have been overlooked. STUDY DESIGN:We performed a cross-sectional study of a nationally representative sampl...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.05.126
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:Contraceptive prevalence is relatively low in Albania, and abortion is the mainstay of family planning. Although levonorgestrel-only emergency contraceptive pills are available, uptake of this method is minimal. Emergency contraception (EC) could play a significant role in addressing women's need for an effe...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.03.033
更新日期：2018-04-11 00:00:00
abstract：OBJECTIVE:To describe clinical outcomes of etonogestrel implant patients with migration to the vasculature, chest wall and other distant body sites spontaneously reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. STUDY DESIGN:We performed a standardized Medical Dictionary ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.08.009
更新日期：2017-12-01 00:00:00
abstract：:A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment. ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(80)90061-x
更新日期：1980-08-01 00:00:00
abstract：OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.06.004
更新日期：2020-10-01 00:00:00
abstract：:This article presents results from a small, introductory clinical study offering a simplified regimen medical abortion to women in Turkey. A total of 208 women from five sites were recruited from July 2000 through March 2001. All eligible consenting women were given 200 mg oral mifepristone at the clinic followed by 4...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2004.05.005
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Weight gain is commonly reported as a side effect of hormonal contraception and can lead to method discontinuation or reluctance to initiate the method. The purpose of this study was to investigate weight change in adolescent (aged 15-19 years) users of depot-medroxyprogesterone acetate (DMPA), norethisteron...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.07.007
更新日期：2010-01-01 00:00:00
abstract：:Comparative phase I clinical trials were carried out in 5 centres with three formulations of beta-hCG-based vaccines inducing antibodies against human chorionic gonadotropin. The objectives of these trials were to determine their relative immunogenicity, duration, reversibility and safety. A total of 116 tubal ligated...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0010-7824(90)90071-3
更新日期：1990-03-01 00:00:00
abstract：:Although weight gain is among the most common complaints of women using oral contraceptives (OC) and a frequent reason for discontinuation, studies demonstrate little basis for this perception. We explored this issue by analyzing the daily weights of 128 women during four cycles of triphasic OC use. The mean weight at...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(98)00127-9
更新日期：1998-12-01 00:00:00
abstract：:A polymeric controlled release vaginal delivery system was developed for 15(S)15-methyl PGF2 alpha methyl ester. This delivery system is a reservoir-type device consisting of laminated membranes that are mounted on an inert holder. The delivery systems were designed to have in vitro steady-state release rates of 50 or...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90085-9
更新日期：1983-02-01 00:00:00
abstract：:Introduction of the birth control pill in the United States in 1960 marked the end of a relatively short period of time (< 10 years) to intentionally produce an oral contraceptive, and the beginning of a relatively long period of controversy surrounding the use of the pill. Availability of the pill had an impact on va...
journal_title：Contraception
pub_type： 历史文章,杂志文章
doi：10.1016/s0010-7824(98)00131-0
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. STUDY DESIGN:This study evaluated in v...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.08.014
更新日期：2015-12-01 00:00:00
abstract：:A randomized comparative study between Nova-T and Copper-T-200 was performed simultaneously in Denmark, Finland and Sweden. The results of 741 postmenstrual insertions with Nova-T and 780 with Copper-T are reported. The pregnancy rate of Nova-T was lower in every age and parity group. The pregnancy rate of Copper-T-20...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(79)80004-9
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:Although widely used, the mechanisms of action of the levonorgestrel emergency contraceptive pill (LNG ECP) are still unclear. There are increasing data to indicate that LNG is particularly effective as an ECP by interrupting follicular development and ovulation. An important outstanding question is whether ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.contraception.2006.08.015
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.08.009
更新日期：2015-01-01 00:00:00
abstract：:The present study was designed to evaluate the effectiveness of a once-weekly regimen of GnRH antagonist followed by a progestin as a potential new contraceptive method. On menstrual cycle days 2, 9, 16, and 23 (onset of menses = Day 1) monkeys were divided into two groups: 1) those injected sc with 0.1 mg/kg Nal-Glu ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(09)91007-1
更新日期：1990-06-01 00:00:00
abstract：:A new synthetic progestagen, Org 2969 (13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol) was administered to 9 healthy normally menstruating women. 3 subjects (Group 1) ingested .030 mg, while 6 (Group 2) ingested .015 mg of the compound daily on Days 1-20 of 1 menstrual cycle. The previous menstrual...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(77)90129-9
更新日期：1977-07-01 00:00:00
abstract：BACKGROUND:The purpose of this pilot project was to test the feasibility of a technique designed to place a copper intrauterine device (IUD) through the hysterotomy incision of an elective cesarean delivery to minimize possible contamination and to guarantee that tailstrings were visible in the vagina for easy removal ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.01.014
更新日期：2009-07-01 00:00:00
abstract：:The aim of this study was to evaluate the effectiveness of lactational amenorrhoea and to determine the relationship between extended breastfeeding and the return of fertility. Breastfeeding pattern, basal body temperature, cervical mucus, salivary ferning, vaginal blood discharge, frequency of sexual intercourse, and...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(00)00101-3
更新日期：2000-04-01 00:00:00
abstract：:The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0010-7824(92)90094-a
更新日期：1992-10-01 00:00:00
abstract：:The morphology and the related composition of T-type intrauterine devices (IUDs) made of gold-plated copper were studied in relation to patient complaints. The removed IUDs were examined without pretreatment by scanning electron microscopy and energy dispersive x-ray spectroscopy. Besides the previously found incrusta...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2004.03.006
更新日期：2004-08-01 00:00:00
abstract：:Phospholipases A2 and C (93 and 500 mU) were administered to uterine horns of Long-Evans adult rats during the first five days of pregnancy. As control material, saline (0.15 M) was administered to contralateral uterine horns. The animals were sacrificed on the ninth day of pregnancy, the uterine horns were removed an...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(82)90023-3
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:I examine Twitter discussion regarding the Texas omnibus abortion restriction bill before, during and after Wendy Davis' filibuster in summer 2013. This critical moment precipitated wide public discussion of abortion. Digital records allow me to characterize the spatial distribution of participants in Texas a...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.07.007
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:We wanted to explore the effects of two different low doses (0.5μM and 0.05μM) of mifepristone, exposed during the receptive period, on the human embryo implantation process, using a well-established three-dimensional in vitro cell culture model, specifically developed to study this process. METHODS:An in v...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.03.009
更新日期：2016-08-01 00:00:00
abstract：INTRODUCTION:Abortion in Turkey has been legal since 1983 and remains so today. Despite this, in 2012 the Prime Minister declared that, in his opinion, abortion was murder. Since then, there has been growing evidence that abortion access particularly in state hospitals is being restricted, although no new legislation h...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.09.009
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:To determine the availability of pharmacist prescribing of hormonal contraception in rural areas of two states. STUDY DESIGN:Cross-sectional survey. RESULTS:Overall, 42% of pharmacies prescribed contraception (Oregon: 46% and New Mexico 19%). A similar proportion of rural pharmacies reported offering pharma...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.11.005
更新日期：2020-03-01 00:00:00
