Fertility regulation in male rats and hamsters with alkylating agents.

Abstract:

:A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment.

journal_name

Contraception

journal_title

Contraception

authors

Howe GR,Steward R

doi

10.1016/0010-7824(80)90061-x

subject

Has Abstract

pub_date

1980-08-01 00:00:00

pages

175-81

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010-7824(80)90061-X

journal_volume

22

pub_type

杂志文章
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    abstract::The temporal effects of oral administration of cyproterone acetate (CPA), a progestational androgen receptor blocker, were studied on the fertility of adult male rat sires, at a dose of 20 mg kg-1 day-1 after 15 days of gavage. The treatment reduced the fertility and weights of accessory sex glands, without altering t...

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2004.11.003

    authors: Aleem M,Padwal V,Choudhari J,Balasinor N,Parte P,Gill-Sharma M

    更新日期:2005-05-01 00:00:00

  • Associations between immediate postpartum long-acting reversible contraception and short interpregnancy intervals.

    abstract:OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.08.016

    authors: Wu M,Eisenberg R,Negassa A,Levi E

    更新日期:2020-12-01 00:00:00

  • Bacteriologic culture results obtained before and after elective midtrimester urea abortion.

    abstract::Twenty patients undergoing elective midtrimester abortion by urea amnioinfusion had bacteriologic culture data obtained before and after the procedure. Despite the presence of pathogens in the vagina and cervix prior to the procedure, only 20% of patients exhibited endometrial growth following abortion. Factors that s...

    journal_title:Contraception

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    doi:10.1016/s0010-7824(78)80002-x

    authors: Burkman RT,Spence MR,Atienza MF,King TM

    更新日期:1978-06-01 00:00:00

  • Study of the effect of ulipristal acetate on human sperm ability to interact with tubal tissue and cumulus-oocyte-complexes.

    abstract:OBJECTIVE:Ulispristal acetate (UPA) is a selective progesterone receptor modulator widely used for emergency contraception (EC). The described main mechanism of action is by inhibiting or delaying ovulation; however, the postovulatory effects of the drug are still on debate. Therefore, the aim of this study was to dete...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.02.019

    authors: Zumoffen C,Gómez-Elías MD,Caille AM,Bahamondes L,Cuasnicú PS,Cohen DJ,Munuce MJ

    更新日期:2017-06-01 00:00:00

  • Treatment of pain during medical abortion.

    abstract::A structured literature review was undertaken to determine, in the context of early medical abortion, the proportion of women who require analgesia, the predictors of analgesia requirement and the most appropriate analgesia regimen. Studies from different centers show wide variations in analgesia use, but, overall, ar...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2006.03.002

    authors: Penney G

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  • A prospective, non-randomized study of home use of mifepristone for medical abortion in the U.S.

    abstract:OBJECTIVE:To determine the acceptability of taking mifepristone at home for early medical abortion in the United States. STUDY DESIGN:This prospective, non-randomized, open-label study at six Planned Parenthood centers gave women with pregnancies up to 63 days' gestation seeking medical abortion the choice of taking m...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.contraception.2015.06.026

    authors: Chong E,Frye LJ,Castle J,Dean G,Kuehl L,Winikoff B

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  • Comparison of remote and in-clinic follow-up after methotrexate/misoprostol abortion.

    abstract:OBJECTIVE:This study compared adherence to follow-up and clinical outcomes between standard in-clinic and remote follow-up after methotrexate/misoprostol abortion. STUDY DESIGN:This nonrandomized trial recruited women requesting medical abortion at two sexual health clinics in Toronto, Canada. Women received methotrex...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2015.05.013

    authors: Dunn S,Panjwani D,Gupta M,Meaney C,Morgan R,Feuerstein E

    更新日期:2015-09-01 00:00:00

  • Weight and body mass index among female contraceptive clients.

    abstract:OBJECTIVES:As obesity may affect the efficacy of some contraceptives, we examined weight, body mass index (BMI) and prevalence of obesity among female contraceptive clients at 231 U.S. health centers. A secondary aim was to analyze differences in contraceptive method use by obesity status. STUDY DESIGN:Cross-sectional...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.02.006

    authors: Kohn JE,Lopez PM,Simons HR

    更新日期:2015-06-01 00:00:00

  • Serum lipids in Chinese patients using oral contraceptive pills.

    abstract::Eighty-four Chinese patients attending the Family Planning Association of Hong Kong for contraception with oral contraceptive pills were randomized into 2 groups. The first group received pills containing 0.15 mg levonorgestrel and 0.03 mg ethinyl oestradiol. The second group received pills containing 0.15 mg desogest...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(90)90126-g

    authors: Ho PC,Liu WT,Kwan MS

    更新日期:1990-01-01 00:00:00

  • Copper levels in maternal and fetal tissues of rabbits bearing intrauterine copper wires.

    abstract::A study was undertaken to determine if copper wire, placed within the uterine lumen after implantation and kept in situ throughout pregnancy, results in an excessive accumulation of the metal in maternal and/or fetal tissues; and if so, what effect if any, such an accumulation may have on both mother and offspring. ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(74)90060-2

    authors: Moo-Young AJ,Tatum HJ

    更新日期:1974-05-01 00:00:00

  • Worldwide variations in the lifetime probability of reproductive cancer in women: implications of best-case, worst-case, and likely-case assumptions about the effect of oral contraceptive use.

    abstract::Cancer incidence in countries representative of three patterns of reproductive cancer and age-specific mortality was used to estimate the effect of oral contraceptive use on the lifetime probability of reproductive cancer under three sets of assumptions about the effects of oral contraceptives. Under the set of assump...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(92)90043-s

    authors: Petitti DB,Porterfield D

    更新日期:1992-02-01 00:00:00

  • Effects of combined oral contraceptive steroids on pituitary-ovarian function during the menstrual cycle of lactating women.

    abstract::The object of this study was to investigate the effects of combined oral contraceptives on pituitary-ovarian function during the menstrual cycle of lactating women whose prolactin levels were usually elevated. Five of six lactating women studied were considered to have the normal menstrual cycle which was comparable t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90008-2

    authors: Ryu K,Yu HK,Kwak HM,Hong SS

    更新日期:1983-03-01 00:00:00

  • Acceptability evaluation of a natural rubber latex, a polyurethane, and a new non-latex condom.

    abstract::After more than a century of reliance on latex condoms, male condoms fabricated from new materials are finally becoming commercially available to consumers. This study was an open label acceptability study that compared three lubricated condom products during vaginal intercourse: a natural rubber latex condom, a polyu...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(00)00119-0

    authors: Frezieres RG,Walsh TL

    更新日期:2000-06-01 00:00:00

  • An initial pharmacokinetic study with a Metered Dose Transdermal Systemfor delivery of the progestogen Nestorone as a possible future contraceptive.

    abstract:BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volun...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2007.08.006

    authors: Fraser IS,Weisberg E,Kumar N,Kumar S,Humberstone AJ,McCrossin L,Shaw D,Tsong YY,Sitruk-Ware R

    更新日期:2007-12-01 00:00:00

  • Doing more for less: identifying opportunities to expand public sector access to safe abortion in South Africa through budget impact analysis.

    abstract:OBJECTIVE(S):To estimate the costs of public-sector abortion provision in South Africa and to explore the potential for expanding access at reduced cost by changing the mix of technologies used. STUDY DESIGN:We conducted a budget impact analysis using public sector abortion statistics and published cost data. We estim...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.07.165

    authors: Lince-Deroche N,Harries J,Constant D,Morroni C,Pleaner M,Fetters T,Grossman D,Blanchard K,Sinanovic E

    更新日期:2018-02-01 00:00:00

  • Patient viewing of the ultrasound image prior to abortion.

    abstract:BACKGROUND:Little research has investigated women's interest in and factors associated with viewing their ultrasound image in abortion care. STUDY DESIGN:Using medical records for all abortion care visits in 2011 (n = 15,575) at an urban abortion provider, we determined the proportion of women who chose to view by soc...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.contraception.2013.07.006

    authors: Kimport K,Upadhyay UD,Foster DG,Gatter M,Weitz TA

    更新日期:2013-11-01 00:00:00

  • A cross-over study of three oral contraceptives containing ethinyloestradiol and either desogestrel or levonorgestrel.

    abstract::A randomised cross-over trial was performed to compare the pharmacodynamic actions of three low-dose oral contraceptives (OCs): Marvelon (150 micrograms desogestrel (DSG)+ 30 micrograms ethinyloestradiol (EE)), Mercilon (150 micrograms DSG + 20 micrograms EE) and Microgynon (150 micrograms levonorgestrel (LNG) + 30 mi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(92)90103-z

    authors: Song S,Chen JK,Yang PJ,He ML,Li LM,Fan BC,Rekers H,Fotherby K

    更新日期:1992-06-01 00:00:00

  • Menstrual patterns and progesterone circulating levels following different procedures of tubal occlusion.

    abstract::This study was undertaken to assess the effects of different tubal occlusion procedures on ovarian function. Three groups of subjects randomized to tubal occlusion by laparoscopy and Yoon ring (24 subjects), minilaparotomy and Yoon ring (19 subjects) and minilaparotomy and Pomeroy (22 subjects), and one separate contr...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(89)90003-6

    authors: Rivera R,Gaitan JR,Ruiz R,Hurley DP,Arenas M,Flores C,Hernandez AB

    更新日期:1989-08-01 00:00:00

  • Follicular development in a 7-day versus 4-day hormone-free interval with an oral contraceptive containing 20 mcg ethinyl estradiol and 1 mg norethindrone acetate.

    abstract:BACKGROUND:Combined oral contraceptive (COC) formulations with 20 mcg ethinyl estradiol (EE) have a greater incidence of ovarian hormone production and follicular development, which can be managed by shortening the number of hormone-free days per COC cycle. This study evaluates differences in follicular development dur...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2008.10.005

    authors: Rible RD,Taylor D,Wilson ML,Stanczyk FZ,Mishell DR Jr

    更新日期:2009-03-01 00:00:00

  • Misoprostol as an adjunct to overnight osmotic dilators prior to second trimester dilation and evacuation: A systematic review and meta-analysis.

    abstract:OBJECTIVE:To understand effect of adjunct misoprostol on cervical preparation with overnight osmotic dilators for dilation and evacuation after 16 weeks gestation. METHODS:We searched on-line reference databases using search terms for second trimester, abortion, misoprostol, and dilators. Randomized controlled trials ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.09.005

    authors: Cahill EP,Henkel A,Shaw JG,Shaw KA

    更新日期:2020-02-01 00:00:00

  • Gestational dating using last menstrual period and bimanual exam for medication abortion in pharmacies and health centers in Nepal.

    abstract:OBJECTIVE:To evaluate whether conducting a bimanual examination prior to medication abortion (MAB) provision results in meaningful changes in gestational age (GA) assessment after patient-reported last menstrual period (LMP) in Nepal. STUDY DESIGN:Women ages 16-45 (n=660) seeking MAB at twelve participating pharmacies...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.06.004

    authors: Averbach S,Puri M,Blum M,Rocca C

    更新日期:2018-10-01 00:00:00

  • "She's on her own": a thematic analysis of clinicians' comments on abortion referral.

    abstract:OBJECTIVE:The objective was to understand the motivations around and practices of abortion referral among women's health providers. METHODS:We analyzed the written comments from a survey of Nebraska physicians and advanced-practice clinicians in family medicine and obstetrics-gynecology about their referral practices ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.01.007

    authors: Homaifar N,Freedman L,French V

    更新日期:2017-05-01 00:00:00

  • Effects of STS 557 on semen and sperm functions in bonnet monkey (Macaca radiata)--a preliminary report.

    abstract::Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm m...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(88)90009-1

    authors: Majumdar SS,Sharma RK,Das RP

    更新日期:1988-06-01 00:00:00

  • Pharmacokinetic profile of nomegestrol acetate and 17β-estradiol after multiple and single dosing in healthy women.

    abstract:BACKGROUND:The pharmacokinetics of the monophasic oral contraceptive nomegestrol acetate (NOMAC) plus 17β-estradiol (E(2)) were investigated after a single dose and multiple dosing. STUDY DESIGN:NOMAC/E2 (2.5 mg/1.5 mg) was administered daily to healthy women (18-50 years, n=23) for 24 days; blood samples for pharmaco...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.07.001

    authors: Gerrits MG,Schnabel PG,Post TM,Peeters PA

    更新日期:2013-02-01 00:00:00

  • Evaluation of sulprostone for second trimester abortions and its effects on liver and kidney function.

    abstract::Sulprostone was given intramuscularly in two dose schedules of 0.5 mg at 4 hourly intervals for 8 doses and 1.0 mg at 8-hour intervals for 4 doses to 56 women in the 12th-20th week of gestation coming for termination of pregnancy. Forty-nine of them aborted within the 30-hour observation period, giving a success rate ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(82)90028-2

    authors: Ranjan V,Hingorani V,Kinra G,Agarwal N,Pande Y

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  • Two-year follow-up of changes in clinical chemistry in Singaporean Norplant-2 rod acceptors: haemostatic changes.

    abstract::A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(89)80004-6

    authors: Singh K,Viegas OA,Koh S,Singh P,Ratnam SS

    更新日期:1989-02-01 00:00:00

  • Pregnancy outcomes associated with extended use of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system beyond 60 months: A chart review of 776 women in Brazil.

    abstract:OBJECTIVE:To assess the contraceptive performance of the 52-mg 20 μg/day levonorgestrel-releasing intrauterine system (LNG-IUS, Mirena; Bayer Oy, Turku, Finland) among women who maintain the same device without changes after 60 months. STUDY DESIGN:This is a chart review study in which we assessed the charts of 766 wo...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.10.007

    authors: Bahamondes L,Fernandes A,Bahamondes MV,Juliato CT,Ali M,Monteiro I

    更新日期:2018-03-01 00:00:00

  • Increased exposure of norethindrone in HIV+ women treated with ritonavir-boosted atazanavir therapy.

    abstract:OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.08.009

    authors: DuBois BN,Atrio J,Stanczyk FZ,Cherala G

    更新日期:2015-01-01 00:00:00

  • Do as we say, not as we do: experiences of unprotected intercourse reported by members of the Society of Family Planning.

    abstract:OBJECTIVES:We examine the lifetime and past-year prevalence and circumstances of unprotected intercourse among members of the Society of Family Planning (SFP), a professional reproductive health organization in the United States. STUDY DESIGN:We invited the membership of SFP (n=477) via email to participate in an anon...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.04.004

    authors: Aiken AR,Trussell J

    更新日期:2015-07-01 00:00:00

  • The effect of orally and vaginally administered misoprostol on inflammatory mediators and cervical ripening during early pregnancy.

    abstract:OBJECTIVES:The objective of the present study was to investigate the effect of vaginally and orally administered misoprostol on the local cervical inflammatory response. METHODS:Healthy women with a normal intrauterine pregnancy between 8 and 12 weeks of gestation presenting for an elective termination of pregnancy by...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.contraception.2005.02.012

    authors: Aronsson A,Ulfgren AK,Ståbi B,Stavreus-Evers A,Gemzell-Danielsson K

    更新日期:2005-07-01 00:00:00