Abstract：
:A study was undertaken to determine if copper wire, placed within the uterine lumen after implantation and kept in situ throughout pregnancy, results in an excessive accumulation of the metal in maternal and/or fetal tissues; and if so, what effect if any, such an accumulation may have on both mother and offspring. Copper wires were inserted into the uterine cavities, near the utero-tubal junction, of rabbits on Day 7 of pregnancy and were allowed to remain in situ until Day 28, at which time the animals were sacrificed. Tissues from mother and offspring were subjected to routine histological examinations and their copper content was determined. A parallel series of sham-operated animals served as the control. Copper was released from the intrauterine copper wires at an average daily rate of 38.81 plus or minus 7.26 mcg. Histological examination of maternal adrenal, brain, heart, kidney, liver, lung, ovary, spleen, and uterus revealed no anatomical abnormalities. There was no increase in copper in any of the tissues except the uteri and placentae of animals bearing intrauterine copper wires. There were no anatomical abnormalities in either fetal brain, heart, kidney, liver, or lung. There was an increase in the amount of copper found in the liver of fetuses obtained from animals bearing intrauterine copper wires. As there were no histological differences between livers of the control and experimental groups, and no evidence of teratological effects due to copper, it is assumed that this small but significant increase in fetal liver copper is insufficient to produce any toxic effects on the offspring.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Moo-Young AJ,Tatum HJdoi
10.1016/0010-7824(74)90060-2subject
Has Abstractpub_date
1974-05-01 00:00:00pages
487-96issue
5eissn
0010-7824issn
1879-0518pii
0010-7824(74)90060-2journal_volume
9pub_type
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