Abstract：
:Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm motility was reduced from the 3rd week of treatment. Complete recovery was observed by the 14th week after withdrawal of treatment. STS 557 may have the potentiality to be used as a chemical contraceptive in the male.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Majumdar SS,Sharma RK,Das RPdoi
10.1016/0010-7824(88)90009-1subject
Has Abstractpub_date
1988-06-01 00:00:00pages
631-41issue
6eissn
0010-7824issn
1879-0518pii
0010-7824(88)90009-1journal_volume
37pub_type
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