Abstract:
BACKGROUND:Cyclofem is a combined injectable contraceptive, containing medroxyprogesterone acetate (MPA) and estradiol cypionate. The objective was to characterize the steady-state pharmacokinetics (PK) using tandem liquid chromatography/mass spectrometry and compare these data to a previous PK study of this formulation in US women. STUDY DESIGN:Fifteen ovulatory, surgically sterile women received three Cyclofem injections, once every 28 days, with serum PK measurements on 23 separate days. Trough levels of estradiol and MPA were obtained on Days 1, 29 and 57, prior to each of the three injections. Steady-state concentrations of MPA and estradiol were assessed during the third treatment month on Days 58, 60, 62, 64, 67, 69, 71, 75, 78 and 85. MPA and serum progesterone levels were measured during the follow-up phase to assess MPA clearance (Days 92, 99, 106, 113, 120, 127, 134 and 141) and return of ovulation (Days 103, 106, 131 and 134). RESULTS:In the steady state, mean serum MPA concentrations peaked at 1.31 ng/mL at 4.1 days. Mean estradiol levels peaked at 254 pg/mL by 3.3 days. Ovulation was suppressed for at least 77 days post third injection in all but one woman. CONCLUSIONS:Once monthly injections of Cyclofem resulted in contraceptive levels of MPA without accumulation of hormones, consistent with a previous US study.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Thurman A,Kimble T,Hall P,Schwartz JL,Archer DFdoi
10.1016/j.contraception.2012.11.010subject
Has Abstractpub_date
2013-06-01 00:00:00pages
738-43issue
6eissn
0010-7824issn
1879-0518pii
S0010-7824(12)00980-8journal_volume
87pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract:BACKGROUND:Between 2006 and 2008, Iowa increased access to family planning services through a Medicaid expansion and a privately funded initiative. During this same time, Iowa expanded access to abortion through telemedicine provision of medical abortion. Despite increased access to abortion services, abortions in Iowa...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.10.009
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Weight gain is commonly reported as a side effect of hormonal contraception and can lead to method discontinuation or reluctance to initiate the method. The purpose of this study was to investigate weight change in adolescent (aged 15-19 years) users of depot-medroxyprogesterone acetate (DMPA), norethisteron...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2009.07.007
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Globally, 14.3% of women of reproductive age use intrauterine contraception (IUC), but the distribution of IUC users is strikingly nonuniform. In some countries, the percentage of women using IUC is <2%, whereas in other countries, it is >40%. Reasons for this large variation are not well documented. The aim...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2013.11.011
更新日期:2014-03-01 00:00:00
abstract::The release of contraceptive steroids through different drug delivery systems into serum and breast milk was investigated in a group of lactating women. Four women in each group were taking either a low dosage progestogen compound like norethisterone (NET) 350 micrograms or d-norgestrel (d-Ng) 50 micrograms alone or l...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90002-5
更新日期:1980-03-01 00:00:00
abstract::Hsp70-2 functions as a molecular chaperone that assists other proteins in their folding, transport and assembly into complexes, and is postulated to be linked to the mechanisms that inhibit apoptosis. Here we have determined the association between Hsp70-2 gene and germ cell apoptosis induced by a high dose of testost...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00357-8
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To describe real-world care seeking and contraception provision in one direct to consumer telemedicine platform. STUDY DESIGN:We described encounters with reproductive age female patients between July 2016 and July 2018 seeking contraception on the American Well telemedicine platform. RESULTS:Of 126,712 tot...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.01.017
更新日期:2020-05-01 00:00:00
abstract::A chemically deglycosylated derivative of ovine luteinizing hormone (LH) exhibited appreciable binding to the receptor but had minimal steroidogenic activity. In immature female rats primed with pregnant mare serum gonadotropin, the deglycosylated LH showed low ovulation-inducing activity. Ovulation induced by ovine L...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90037-2
更新日期:1980-06-01 00:00:00
abstract::Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90005-7
更新日期:1983-03-01 00:00:00
abstract::The mechanism of action of intrauterine devices varies from one type of device to another, although the principle of action is the same, namely, to interfere with the physiology of reproduction at the endometrial level. The biochemical changes of the endometrial tissue and the composition of the uterine fluid have bee...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(87)90058-8
更新日期:1987-07-01 00:00:00
abstract::This article examines interrelated questions concerning the extent of need for contraception in women 40 years and older and the degree to which that need can be served when use of collared T IUDs is initiated in women aged 25-35 years. Differentials in the impacts of intrauterine device (IUD) use on health issues in ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2007.01.016
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:Single-visit intrauterine device (IUD) insertion protocols are recommended. We assessed the availability of single-visit IUD insertions, and whether access to these services varies by age, race or parity. STUDY DESIGN:Using audit study methodology, we called a random sample of 396 obstetrician-gynecology pra...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.05.007
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN:We administered a nationally-representative, ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.09.010
更新日期:2018-03-01 00:00:00
abstract::There is agreement that the relative risk of developing pelvic inflammatory disease (PID) increases among women who use the intrauterine contraceptive device (IUD). The role of Chlamydia in causing PID among IUD users is not clear. The present study demonstrates that Chlamydia trachomatis growth can be inhibited in cu...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90041-3
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:Concern about pain during placement of an intrauterine device (IUD) represents a barrier to use, especially among nulliparous women. We hypothesized that nitroglycerin gel applied vaginally 30 min prior to IUD placement would reduce insertion-related pain. STUDY DESIGN:We designed a randomized, double-blinde...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2014.03.012
更新日期:2014-07-01 00:00:00
abstract::The requirement that every woman desiring medical abortion must come in person to a clinical facility to obtain the drugs is a substantial barrier for many women. To eliminate this requirement in the United States, two key components of the standard initial visit would need to be restructured. First, alternatives to u...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.06.020
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:The study was conducted to evaluate ethinyl estradiol (EE) or ibuprofen (IBU) compared to placebo (PL) on spotting and bleeding (S/B) and a postcoital test (PCT) in women using the levonorgestrel subcutaneous implant. Women experiencing excessive S/B were enrolled in a multicenter prospective randomized stud...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2008.04.003
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.01.001
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Extensive data from clinical trials document mifepristone's safety and efficacy for induced abortion, but less information is available about its safety in routine clinical use. METHODS:Data on mifepristone abortion use from the Planned Parenthood Federation of America, the largest provider of mifepristone ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.03.011
更新日期:2005-09-01 00:00:00
abstract::California is home to more than one out of eight American women of reproductive age. Because California has a large, diverse and growing population, national statistics do not necessarily describe the reproductive health of California women. This article presents risk for pregnancy and sexually transmitted infections ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.01.012
更新日期:2004-07-01 00:00:00
abstract::A randomized comparative study between Nova-T and Copper-T-200 was performed simultaneously in Denmark, Finland and Sweden. The results of 741 postmenstrual insertions with Nova-T and 780 with Copper-T are reported. The pregnancy rate of Nova-T was lower in every age and parity group. The pregnancy rate of Copper-T-20...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(79)80004-9
更新日期:1979-01-01 00:00:00
abstract::Researchers, health care providers, women's health advocates, donors, and representatives of ministries of health convened in Bellagio, Italy, in July 1998, to assess the potential of medical methods of early pregnancy termination to improve the reproductive health of women in developing countries. Consensus was reac...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(98)00109-7
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:The study was undertaken to determine the side effects, including depression, of oral contraceptives (OCs) in adolescent girls. METHODS:We conducted a randomized trial of OCs for dysmenorrhea, which assessed side effects and depression. Seventy-six adolescents received an OC (20 microg of ethinyl estradiol/1...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2006.09.008
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Lactic acid production is considered to be the major protection mechanism of lactobacilli against vaginal infections due to genital pathogens. Some species of Lactobacillus are also hydrogen peroxide (H(2)O(2)) producers. Nonoxynol-9 (N-9) is a nonionic detergent and is the active component of many spermicid...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.06.066
更新日期:2006-01-01 00:00:00
abstract::Scarce data are available on the relation between the effectiveness of intrauterine device (IUD) and the gynecologic features of a woman. A nested case-control study was conducted to determine whether the uterine position and hysterometry affect the pregnancy rate of copper IUD. Seventy-one cases (pregnant women with ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00480-8
更新日期:2003-03-01 00:00:00
abstract::Effect of RISUG, a newly developed male contraceptive, on various amino acids of seminal plasma ejaculates was studied by proton magnetic resonance spectroscopy at 400 MHz. Levels of amino acids were compared with the seminal plasma of obstructive azoospermia and controls. Glutamic acid, glutamine, and arginine were f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00343-8
更新日期:2002-09-01 00:00:00
abstract::Numerous non-comparative clinical trials of the Dalkon Shield appear to provide ample evidence that the Dalkon Shield was an effective IUD; they seem to yield little evidence that it was a dangerous device, nor markedly different from its contemporaries. Equating the performance of the Dalkon Shield IUD to that of the...
journal_title:Contraception
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1016/0010-7824(93)90060-k
更新日期:1993-07-01 00:00:00
abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90107-i
更新日期:1993-01-01 00:00:00
abstract::Presumably, Latino women engage in little family planning because of religious or cultural objections to contraception. The purpose of this study was to examine how acculturation, religion and various demographic factors were related to the family-planning behaviors of Latino women in the United States. Data were coll...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.10.011
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2009.02.007
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of miPlan, a waiting-room contraceptive counseling mobile application (app), on interest in discussing long-acting reversible contraception (LARC) during the clinical encounter and LARC uptake. STUDY DESIGN:This randomized controlled trial evaluated the miPlan contraceptive counseling ...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2018.07.001
更新日期:2018-10-01 00:00:00