Abstract:
OBJECTIVE:The study was undertaken to determine the side effects, including depression, of oral contraceptives (OCs) in adolescent girls. METHODS:We conducted a randomized trial of OCs for dysmenorrhea, which assessed side effects and depression. Seventy-six adolescents received an OC (20 microg of ethinyl estradiol/100 mg of levonorgestrel) or a placebo in a double-blind fashion for 3 months. We ascertained OC side effects using open-ended and closed question formats. Participants self-administered the Center for Epidemiologic Studies Depression Scale (CES-D) to assess depressive symptoms. RESULTS:Fifty-seven participants (77%) reported at least one side effect (median=2, range=0-8, interquartile range=1.0-3.25). The number and the type of side effects reported in the OC group and in the placebo group were similar. Mean exit CES-D scores were comparable between groups [OC group, 14.0 (SD=9.2); placebo group, 14.4 (SD=8.1); p=.86]. CONCLUSION:Adolescents treated with an OC or a placebo experienced similar numbers and types of OC side effects, as well as depressive symptoms.
journal_name
Contraceptionjournal_title
Contraceptionauthors
O'Connell K,Davis AR,Kerns Jdoi
10.1016/j.contraception.2006.09.008subject
Has Abstractpub_date
2007-04-01 00:00:00pages
299-304issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(06)00363-5journal_volume
75pub_type
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