Abstract:
BACKGROUND:Emergency contraception (EC) does not always work. Clinicians should be aware of potential risk factors for EC failure. STUDY DESIGN:Data from a meta-analysis of two randomized controlled trials comparing the efficacy of ulipristal acetate (UPA) with levonorgestrel were analyzed to identify factors associated with EC failure. RESULTS:The risk of pregnancy was more than threefold greater for obese women compared with women with normal body mass index (odds ratio (OR), 3.60; 95% confidence interval (CI), 1.96-6.53; p<.0001), whichever EC was taken. However, for obese women, the risk was greater for those taking levonorgestrel (OR, 4.41; 95% CI, 2.05-9.44, p=.0002) than for UPA users (OR, 2.62; 95% CI, 0.89-7.00; ns). For both ECs, pregnancy risk was related to the cycle day of intercourse. Women who had intercourse the day before estimated day of ovulation had a fourfold increased risk of pregnancy (OR, 4.42; 95% CI, 2.33-8.20; p<.0001) compared with women having sex outside the fertile window. For both methods, women who had unprotected intercourse after using EC were more likely to get pregnant than those who did not (OR, 4.64; 95% CI, 2.22-8.96; p=.0002). CONCLUSIONS:Women who have intercourse around ovulation should ideally be offered a copper intrauterine device. Women with body mass index >25 kg/m(2) should be offered an intrauterine device or UPA. All women should be advised to start effective contraception immediately after EC.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Glasier A,Cameron ST,Blithe D,Scherrer B,Mathe H,Levy D,Gainer E,Ulmann Adoi
10.1016/j.contraception.2011.02.009subject
Has Abstractpub_date
2011-10-01 00:00:00pages
363-7issue
4eissn
0010-7824issn
1879-0518pii
S0010-7824(11)00061-8journal_volume
84pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract::The effect of consecutively injecting a one-a-month contraceptive (norethisterone enantate 50 mg with estradiol valerate 5 mg) for one year on haematological parameters was evaluated in 42 Chinese women. The healthy volunteers were randomly allocated to either the treatment group (22) or a control group (20). Blood sa...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(90)90052-w
更新日期:1990-10-01 00:00:00
abstract::The evaluation of the study was of the impact of oral contraceptive (OC) use on activated protein C (APC-resistance). Eight hundred eighteen young fertile women were screened for a study designed to compare three different marketed OC preparations. The women could have used either other oral contraceptive preparations...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(01)00253-0
更新日期:2001-10-01 00:00:00
abstract::The Indian Council of Medical Research initiated a multicentric trial with prostaglandins in 1976 to assess the safety and efficacy of their use in midtrimester abortions. PGF2 alpha and 15-Me-PGF2 alpha were compared using the intra-amniotic (I.A.) route. 15-Me-PGF2 alpha was also evaluated by extra-amniotic (E.A.) r...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(78)90048-3
更新日期:1978-12-01 00:00:00
abstract:OBJECTIVE:To evaluate whether conducting a bimanual examination prior to medication abortion (MAB) provision results in meaningful changes in gestational age (GA) assessment after patient-reported last menstrual period (LMP) in Nepal. STUDY DESIGN:Women ages 16-45 (n=660) seeking MAB at twelve participating pharmacies...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2018.06.004
更新日期:2018-10-01 00:00:00
abstract::A polymeric controlled release vaginal delivery system was developed for 15(S)15-methyl PGF2 alpha methyl ester. This delivery system is a reservoir-type device consisting of laminated membranes that are mounted on an inert holder. The delivery systems were designed to have in vitro steady-state release rates of 50 or...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90085-9
更新日期:1983-02-01 00:00:00
abstract:OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.01.009
更新日期:2020-05-01 00:00:00
abstract::To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(72)90011-x
更新日期:1972-06-01 00:00:00
abstract::Adult female rats were given a single, subcutaneous injection of 8, 16 or 32 micrograms of levonorgestrel (LNG). Blood samples were collected at various time intervals and serum concentrations of LNG were determined by radioimmunoassay. The patterns of temporal decline in LNG concentrations in the three dose groups in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(84)90009-x
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2009.02.007
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether mental illness and substance use disorder (SUD) are associated with having a prescription contraceptive method among women veterans. STUDY DESIGN:We conducted a retrospective analysis of National Veterans Administration (VA) administrative and clinical data for women veterans aged 18-4...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.02.028
更新日期:2014-07-01 00:00:00
abstract::The study of a modified minilaparotomy technique of interval female sterilization is reported. The modified minilaparotomy technique of interval female sterilization is performed under local anesthesia using the Ramathibodi uterine manipulator, bivalve speculum, and a low midline incision. Sixty cases were treated wit...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(97)00043-7
更新日期:1997-06-01 00:00:00
abstract::The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0010-7824(92)90094-a
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:The pharmacokinetics of the monophasic oral contraceptive nomegestrol acetate (NOMAC) plus 17β-estradiol (E(2)) were investigated after a single dose and multiple dosing. STUDY DESIGN:NOMAC/E2 (2.5 mg/1.5 mg) was administered daily to healthy women (18-50 years, n=23) for 24 days; blood samples for pharmaco...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.07.001
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2016.06.012
更新日期:2016-12-01 00:00:00
abstract::The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(94)90019-1
更新日期:1994-10-01 00:00:00
abstract::This study analyzed data gathered from a survey of online information on the intrauterine device (IUD) to determine the content and quality of information available to consumers and providers, as evidenced by the presence or absence of a series of attributes measuring the accuracy and objectiveness of information prov...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.07.001
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:The study was conducted to characterize the changes in bleeding pattern over time in women receiving the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding (HMB). The reduction in menstrual blood loss volume has been well documented elsewhere. STUDY DESIGN:Post hoc pooled an...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2012.08.022
更新日期:2013-01-01 00:00:00
abstract::Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90020-3
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVES:The objective was to measure the rate of unintended pregnancies in women using levonorgestrel-releasing intrauterine systems (LNG IUSs, releasing 20 mcg LNG daily) and copper intrauterine devices (IUDs) in a typical population of IUD users and to describe associated complications. METHODS:A multinational, p...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.contraception.2015.01.011
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE(S):To estimate the costs of public-sector abortion provision in South Africa and to explore the potential for expanding access at reduced cost by changing the mix of technologies used. STUDY DESIGN:We conducted a budget impact analysis using public sector abortion statistics and published cost data. We estim...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.07.165
更新日期:2018-02-01 00:00:00
abstract::This study was designed to investigate the effects of repeated high doses of an LHRH agonist on Swiss porton mouse seminiferous epithelium. Seminiferous epithelium showed more pronounced degenerative effects at the higher dose (1000 micrograms/kg wt/day) of the drug, with arrest of spermatogenesis at all stages of dif...
journal_title:Contraception
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:The Copper T intrauterine device (IUD) is a safe, effective, reversible contraceptive that is used widely worldwide but little in South Africa. This study assesses the knowledge, attitudes and practices of potential IUD users and health care providers to inform strategies for expanding IUD use in South Afric...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.07.009
更新日期:2011-02-01 00:00:00
abstract::This study examines contraceptive delivery characteristics and their association with contraceptive behavior. Data were collected in telephone interviews from a national sample of 1057 women who were using female contraceptives. The overwhelming majority of the sample obtained contraceptive services from gynecologists...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90074-7
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To develop a nurse-led model of medication abortion provision for the primary health care setting of regional and rural Victoria, where, despite decriminalization, access to abortion services is restricted. STUDY DESIGN:This study used a three-round Delphi process to explore consensus about a nurse-led medic...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.07.004
更新日期:2019-11-01 00:00:00
abstract::Gossypol, a polyphenolic pigment found in cotton plants, has been implicated as an antifertility agent. This pigment has been shown to alter myriad metabolic pathways. The objective of this study was to determine the effect of gossypol acetic acid on the hepatic microsomal drug metabolizing enzyme system in adult fema...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(90)90009-k
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:Women who have abortions are at high risk of contraception discontinuation and subsequent unintended pregnancy. The objective of this analysis was to identify factors associated with choice of highly effective, long-acting, progestin-only contraceptive methods after abortion. STUDY DESIGN:Women presenting fo...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.06.013
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.08.009
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:As part of a strategy to revitalize postpartum family planning services, Government of India revised its policy in 2013 to permit trained nurses and midwives to insert postpartum intrauterine contraceptive devices (PPIUCDs). This study compares two key outcomes of PPIUCD insertions--expulsion and infection--f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.12.012
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:To examine contraceptive use, pregnancy intention and the association of hormonal contraceptive type with adverse health outcomes among women with cystic fibrosis (CF). STUDY DESIGN:We recruited 150 women with CF, ages 18-49 from three adult CF programs to complete an online survey regarding their pregnancy...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.02.006
更新日期:2020-06-01 00:00:00
abstract::Information relating to the effect of steroids on the metabolism and motility of human spermatozoa is limited despite the increasing interest in the use of these hormones for the purpose of contraception. In the present study it was shown that progesterone, testosterone, and 11-beta-OH-progesterone significantly inhib...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90080-9
更新日期:1981-05-01 00:00:00