Effects of gossypol on the hepatic drug metabolizing system in rats.

abstract：:The mechanism of copper in limiting intrauterine infections in intrauterine device (Cu IUD) users is poorly understood. Copper ions may enhance the release of reactive oxygen radicals, which in turn decrease the release of reactive nitrogen intermediates (RNI). RNI are known to have bactericidal effect. The present st...

journal_title：Contraception

authors： Pradhan M,Gupta I,Ganguli NK

更新日期：1997-05-01 00:00:00

abstract：:A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...

journal_title：Contraception

authors： Sassolas A,Lagarde M,Guichardant M,Quincy C,Dechavanne M

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Developing an objective, reliable method to determine semen exposure in cervicovaginal fluids is important for accurately studying the efficacy of vaginal microbicides and contraceptives. Y-chromosome biomarkers offer better stability, sensitivity, and specificity than protein biomarkers. TSPY4 belongs to th...

journal_title：Contraception

authors： Jacot TA,Zalenskaya I,Mauck C,Archer DF,Doncel GF

更新日期：2013-09-01 00:00:00

abstract：:To assess how Flemish general practitioners (GPs) are handling the first contraception consultation, we used standardized patients (SPs) as the best method to assess the performance of GPs in daily practice. Thirty GPs got a visit from one of the three SPs. Based on a validated checklist, the SPs scored the performanc...

journal_title：Contraception

authors： Peremans L,Rethans JJ,Verhoeven V,Debaene L,Van Royen P,Denekens J

更新日期：2005-06-01 00:00:00

abstract：:After exposure of young male rats to gossypol acetic acid for various times, a reduction in the content of cellular and microtubular beta-tubulin was found in spermatocytes and spermatids. The content of tubulin was measured by enzyme-linked immunosorbent assay (ELISA). The results were expressed as micrograms tubulin...

journal_title：Contraception

authors： Teng CS

更新日期：1997-01-01 00:00:00

abstract：:A randomized comparative study between Nova-T and Copper-T-200 was performed simultaneously in Denmark, Finland and Sweden. The results of 741 postmenstrual insertions with Nova-T and 780 with Copper-T are reported. The pregnancy rate of Nova-T was lower in every age and parity group. The pregnancy rate of Copper-T-20...

journal_title：Contraception

authors： Luukkainen T,Nielsen NC,Nygren KG,Pyörälä T,Allonen H

更新日期：1979-01-01 00:00:00

abstract：:New studies linking use of oral contraceptives (OCs) containing a third generation progestogen with venous thromboembolism (VTE) have stirred controversy. Epidemiologists face the task of separating a direct effect of the OC from the confounding effect of a pre-existing factor (e.g., smoking). Only 1-2% of VTE cases...

journal_title：Contraception

authors： Westhoff CL

更新日期：1996-07-01 00:00:00

abstract：:A simple survey was made of health-care providers to determine their attitudes toward oral contraceptives containing more than 50 mcg of estrogen. It was found that about two-thirds of respondents prescribe this group of medication, although few do so regularly. Their use seemed correlated with providers 40 years of a...

journal_title：Contraception

authors： Grossman RA

更新日期：1988-11-01 00:00:00

abstract：:Ovarian function, bleeding patterns and serum lipoproteins were studied in women using contraceptive vaginal rings (CVRs) of dimethyl-polysiloxane impregnated with steroids. The different CVRs were used for about 10 cycles each. The following groups were studied, with the daily steroid dosage given in parentheses. Wom...

journal_title：Contraception

authors： Ahrén T,Victor A,Lithell H,Vessby B,Jackanicz TM,Johansson ED

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:There is a lack of information concerning the decision factors and sources of information influencing women who purposefully deviate from the prescribed use of their combined hormone contraceptives to exert elective control of their scheduled bleeding. STUDY DESIGN:A self-administered email survey of schedu...

journal_title：Contraception

authors： Lakehomer H,Kaplan PF,Wozniak DG,Minson CT

更新日期：2013-09-01 00:00:00

abstract：:A structured literature review was undertaken to determine, in the context of early medical abortion, the proportion of women who require analgesia, the predictors of analgesia requirement and the most appropriate analgesia regimen. Studies from different centers show wide variations in analgesia use, but, overall, ar...

journal_title：Contraception

authors： Penney G

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To explore how doula support influences women's experiences with first-trimester surgical abortion. STUDY DESIGN:We conducted semistructured interviews with women given the option to receive doula support during first-trimester surgical abortion in a clinic that uses local anesthesia and does not routinely a...

journal_title：Contraception

authors： Chor J,Lyman P,Tusken M,Patel A,Gilliam M

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To describe real-world care seeking and contraception provision in one direct to consumer telemedicine platform. STUDY DESIGN:We described encounters with reproductive age female patients between July 2016 and July 2018 seeking contraception on the American Well telemedicine platform. RESULTS:Of 126,712 tot...

journal_title：Contraception

authors： Martinez KA,Rastogi R,Lipold L,Rothberg MB

更新日期：2020-05-01 00:00:00

abstract：:A multicentric trial in 9 Spanish Clinics of Family Planning was conducted to evaluate the effectiveness of a vaginal contraceptive Ovule (suppository), containing 18.9 mg of benzalkonium chloride. Gynaecological and cytobacteriological examinations were made to evaluate any possible side-effect. Six-hundred-fifty-thr...

journal_title：Contraception

authors： Méndez F,Castro A,Ortega A

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:To assess unintended pregnancy risk and associated factors among female urban Baltimore emergency department (ED) attendees. METHODS:A cross-sectional anonymous questionnaire study was completed by 790 women, sufficient to detect a 5% difference of unintended pregnancy risk in the national population and a 1...

journal_title：Contraception

authors： Todd CS,Mountvarner G,Lichenstein R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...

journal_title：Contraception

authors： Pagano HP,Zapata LB,Berry-Bibee EN,Nanda K,Curtis KM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate long-term safety of quinacrine pellets for nonsurgical sterilization among women in Vietnam. STUDY DESIGN:Observational cohort study of 2735 women who had quinacrine insertions between 1989 and 1993 compared to 1623 women who received an intrauterine device (IUD). RESUL...

journal_title：Contraception

authors： Sokal DC,Hieu do T,Loan ND,Hubacher D,Nanda K,Weiner DH,Vach TH

更新日期：2008-07-01 00:00:00

abstract：:The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...

journal_title：Contraception

authors： Walsh TL,Bernstein GS,Grimes DA,Frezieres R,Bernstein L,Coulson AH

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:This study evaluated the ethinyl estradiol (EE) and levonorgestrel (LNG) pharmacokinetic profiles of AG200-15, a transdermal contraceptive delivery system, compared with a combination oral contraceptive (COC) containing EE 35 mcg and norgestimate 250 mcg. STUDY DESIGN:A Phase 1, open-label, single-center st...

journal_title：Contraception

authors： Archer DF,Stanczyk FZ,Rubin A,Foegh M

更新日期：2012-06-01 00:00:00

abstract：:To determine knowledge of, attitudes toward, and use of emergency contraception (EC), interviews were held with 1068 clients of 89 public sector primary healthcare facilities in two urban and two rural areas of South Africa. Only 22.8% of the clients had heard of EC. Awareness was significantly lower in the most rural...

journal_title：Contraception

authors： Smit J,McFadyen L,Beksinska M,de Pinho H,Morroni C,Mqhayi M,Parekh A,Zuma K

更新日期：2001-12-01 00:00:00

abstract：:This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashio...

journal_title：Contraception

authors： Snyder BW,Schane HP

更新日期：1985-05-01 00:00:00

abstract：:This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...

journal_title：Contraception

authors： Srivastava A,Gupta G,Setty BS

更新日期：1989-03-01 00:00:00

abstract：:A five-year study of NORPLANT II rod implants was undertaken in four large cities and metropolitan areas in eastern China. Designed to test the safety, efficacy and acceptability of these implants, the study involved 1,208 women and was conducted concurrently with a similar study of NORPLANT capsule implants. At the e...

journal_title：Contraception

authors： Gu S,Du M,Zhang L,Liu Y,Wang S,Sivin I

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the effectiveness of a refined theory-based Interactive Postpartum Sexual Health Education Program to enhance postpartum women's effective contraceptive behavior. STUDY DESIGN:Participants (N=250) were randomized to three groups. Experimental Group A received our interv...

journal_title：Contraception

authors： Lee JT,Tsai JL,Tsou TS,Chen MC

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the presence of ovarian cysts in women using a new low-dose levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 13.5mg [total content]). STUDY DESIGN:A Phase 3 study assessed LNG-IUS 13.5mg use in healthy women with regular menstrual cycles who requested co...

journal_title：Contraception

authors： Nahum GG,Kaunitz AM,Rosen K,Schmelter T,Lynen R

更新日期：2015-05-01 00:00:00

abstract：:The potential use of tamoxifen, a nonsteroidal antiestrogen, as an antifertility agent was studied in the long-tailed macaque (Macaca fascicularis). Twenty-six cycling females were bred, then treated with a single oral dose of tamoxifen (5 mg/kg) (N = 13) or vehicle (N = 13) on day 4 post-ovulation. Serum progesterone...

journal_title：Contraception

authors： Tarantal AF,Hendrickx AG,Matlin SA,Lasley BL,Gu QQ,Thomas CA,Vince PM,Van Look PF

更新日期：1993-03-01 00:00:00

abstract：:This was a dual-cohort study performed to determine if, by using methotrexate alone, abortions could be induced with fewer side effects, without sacrificing effectiveness and patient satisfaction. The subjects were 358 consecutive patients who requested elective medical termination of pregnancy at < 7 weeks gestation....

journal_title：Contraception

authors： Wiebe ER

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To determine if laparoscopic sterilization using the Filshie clip causes less postoperative pain as compared to the Falope ring during the first 24 h after surgery. STUDY DESIGN:Forty subjects were enrolled. Five milliliters of 0.5% bupivicaine was injected at each of the two incision sites and 5 mL was drip...

journal_title：Contraception

authors： Pymar HC,Creinin MD,Vallejo MC

更新日期：2004-02-01 00:00:00

abstract：:In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...

journal_title：Contraception

authors： Shain RN

更新日期：1980-09-01 00:00:00

abstract：:After more than a century of reliance on latex condoms, male condoms fabricated from new materials are finally becoming commercially available to consumers. This study was an open label acceptability study that compared three lubricated condom products during vaginal intercourse: a natural rubber latex condom, a polyu...

journal_title：Contraception

authors： Frezieres RG,Walsh TL

更新日期：2000-06-01 00:00:00