Abstract：
:This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The treatment caused a marked reduction in the weights of testis and epididymis. Histological examination of the testis in the two species revealed presence of seminiferous tubules showing varying degrees of damage along with a large number of normal tubules. Exfoliation of germ cells and spermatogenic arrest at spermatid stage was a common feature. Leydig cells presented normal morphological features. Though there was a reduction in the diameter of epididymal tubules, the epithelium did not show any morphological alterations. Examination of vasal flushings revealed marked reduction in sperm population and consisted of decapitated and immotile spermatozoa. Gossypol caused a significant reduction in the levels of total protein, RNA and DNA, and a marginal decrease in glycogen content in the testis. This was accompanied by a reduction in the activities of SDH and MDH. Except for LDH activity which showed a marked rise, there was no effect on glycolytic enzymes in the testis. The concentrations of glycerylphosphorylcholine and sialic acid were reduced in the cauda epididymis. The antifertility effects of gossypol appear to be due to its action both on testis as well as on epididymis.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Srivastava A,Gupta G,Setty BSdoi
10.1016/0010-7824(89)90066-8subject
Has Abstractpub_date
1989-03-01 00:00:00pages
337-55issue
3eissn
0010-7824issn
1879-0518pii
0010-7824(89)90066-8journal_volume
39pub_type
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