Abstract:
BACKGROUND:A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutaneous injection (104 mg/0.65 mL; DMPA-SC) and achieves highly effective contraception with a similar tolerability profile to intramuscular DMPA (150 mg/mL; DMPA-IM). STUDY DESIGN:This randomized, evaluator-blinded study was designed to compare efficacy, safety, and user satisfaction in women receiving DMPA-SC (n=266) or DMPA-IM (n=268) for 2 years with an option to continue for a third year. The primary objectives were to evaluate bone mineral density (BMD) changes and contraceptive efficacy after 2 years. RESULTS:A total of 225 women completed the first 2 years of this study (DMPA-SC, n=116; DMPA-IM, n=109). After 2 years of DMPA use, BMD loss was marginally smaller in the DMPA-SC group than in the DMPA-IM group at both the total hip (-3.3% and -3.6%, respectively) and lumbar spine (-4.3% and -5.0%, respectively). In those women who received DMPA during the third year, there were no statistically significant differences in BMD loss between DMPA-SC and DMPA-IM groups at the end of Year 3. Recovery of BMD was observed in the small subpopulation of women who had discontinued DMPA-SC or DMPA-IM after the second year. The 2-year treatment-failure cumulative pregnancy rate was 0% in the DMPA-SC group and 0.8% (95% confidence interval, 0.00-2.37%) in the DMPA-IM group (life-table method). Adverse events were similar in the two groups except that injection site reactions were more common in the DMPA-SC group. CONCLUSION:DMPA-SC is an effective and well-tolerated contraceptive option, providing comparable efficacy and BMD safety to DMPA-IM.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Kaunitz AM,Darney PD,Ross D,Wolter KD,Speroff Ldoi
10.1016/j.contraception.2009.02.005subject
Has Abstractpub_date
2009-07-01 00:00:00pages
7-17issue
1eissn
0010-7824issn
1879-0518pii
S0010-7824(09)00045-6journal_volume
80pub_type
杂志文章,多中心研究,随机对照试验相关文献
CONTRACEPTION文献大全abstract:BACKGROUND:The study was conducted to characterize the changes in bleeding pattern over time in women receiving the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding (HMB). The reduction in menstrual blood loss volume has been well documented elsewhere. STUDY DESIGN:Post hoc pooled an...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2012.08.022
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:The objective of the present study was to investigate the effect of vaginally and orally administered misoprostol on the local cervical inflammatory response. METHODS:Healthy women with a normal intrauterine pregnancy between 8 and 12 weeks of gestation presenting for an elective termination of pregnancy by...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.contraception.2005.02.012
更新日期:2005-07-01 00:00:00
abstract::Injection of a polymer, styrene maleic anhydride (SMA), into the lumen of the vas deferens of rats, was observed to have effective and reversible contraception. The safety evaluation of the polymer, for 90 days, was carried out in Charles Foster male rats. There have been no significant changes in any of the toxicity ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(89)80010-1
更新日期:1989-02-01 00:00:00
abstract::Patients taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine together with their oral contraceptive steroid may suffer contraceptive failure because of the enzyme-inducing properties of these anticonvulsants. We have examined, in six women, the effect of sodium valproate, an effective broad spec...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90028-4
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:This study was conducted to assess the efficacy and incidence of side effects of a regimen of repeated doses of 400 microg sublingual misoprostol for termination of pregnancy of <7 weeks gestation. METHOD:Fifty women were given 400 microg sublingual misoprostol every 3 h for three doses. Two additional dose...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(03)00134-3
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Between 7% and 10% of men who choose vasectomy as a contraceptive method regret their decision. This study evaluates the effect of a patient decision aid (PtDA) designed to help men decide whether or not to have a vasectomy. STUDY DESIGN:Men considering vasectomy were randomized to an experimental group tha...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2010.05.003
更新日期:2010-12-01 00:00:00
abstract::This article presents results from a small, introductory clinical study offering a simplified regimen medical abortion to women in Turkey. A total of 208 women from five sites were recruited from July 2000 through March 2001. All eligible consenting women were given 200 mg oral mifepristone at the clinic followed by 4...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.05.005
更新日期:2004-11-01 00:00:00
abstract::Blood pyrodoxine hydrochloride (vitamin-B6) concentration was determined in 50 women using combined oral contraceptives (OCs), 24 women who received an intramuscular injection of 150 mg medroxyprogesterone acetate (MPA) every 12 weeks, and in 14 women who used an intrauterine device (IUD) at the out-patient contracep...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(74)90078-x
更新日期:1974-04-01 00:00:00
abstract:BACKGROUND:Experimental evidences suggest that metabolic activation and conversion of oral contraceptive pills (OCPs) to reactive species are responsible for their genotoxicity. The present study was undertaken to investigate the effects of low-dose (LD) OCPs on the activities of erythrocyte antioxidant enzymes glutath...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.07.026
更新日期:2011-04-01 00:00:00
abstract::A questionnaire study was carried out to investigate the needs of women undergoing a medical abortion induced by mifepristone in combination with either gemeprost pessaries or oral misoprostol. One-hundred-and-eighty women undergoing medical abortion of pregnancy of up to 63 days amenorrhoea were randomised to treatme...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(92)90147-l
更新日期:1992-11-01 00:00:00
abstract::To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed ...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(96)00174-6
更新日期:1996-09-01 00:00:00
abstract::The effect of alpha-chlorohydrin (3-chloropropan-1,2-diol) on the metabolism of D-[U-14C]-fructose and L-[U-14C]-lactate by washed boar sperm has been investigated. Whereas alpha-chlorohydrin at concentrations as low as 0.1 mM inhibited the metabolism of fructose and led to an increase in the utilization of endogenous...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90103-1
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2016.06.012
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE(S):To estimate the costs of public-sector abortion provision in South Africa and to explore the potential for expanding access at reduced cost by changing the mix of technologies used. STUDY DESIGN:We conducted a budget impact analysis using public sector abortion statistics and published cost data. We estim...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.07.165
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Previous survey research indicates that women and men experience reduced sexual pleasure when using condoms, especially compared to nonbarrier family planning methods. This study seeks to explore those experiences of reduced pleasure in-depth and how they affect contraceptive method decisions and use. STUDY ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.11.012
更新日期:2014-04-01 00:00:00
abstract::A prospective randomized trial was conducted in 140 women to compare the efficacy of vaginal gemeprost with vaginal misoprostol for termination of second trimester pregnancy. Women requesting termination of second trimester pregnancy were randomized into two groups. Group A women were given 1 mg vaginal gemeprost ever...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(98)00099-7
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:The Affordable Care Act (ACA) will expand health care coverage to low-income Americans. Contraception services are a mandated component of ACA plans. STUDY DESIGN:A decision-analytic model was developed to compare the costs and outcomes of the current versus the proposed plan for contraceptive coverage (Fed...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.06.009
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:To assess clinician provision of hormonal contraception for HIV-positive and at-risk women in Southern Africa. STUDY DESIGN:We conducted a nationally representative survey of clinicians (n=1444) in HIV-prevalent settings in South Africa and Zimbabwe to evaluate evidence-based contraceptive care and clinicia...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.04.010
更新日期:2014-10-01 00:00:00
abstract::The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/0010-7824(92)90094-a
更新日期:1992-10-01 00:00:00
abstract::Twelve young women were prospectively evaluated for the short-term metabolic effects of a low-dose oral contraceptive containing 30 micrograms ethinyl estradiol and 150 micrograms levonorgestrel. To each volunteer a 50 g glucose challenge was administered monthly as a screening test for changes in the glucose metaboli...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90080-x
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Little research has investigated women's interest in and factors associated with viewing their ultrasound image in abortion care. STUDY DESIGN:Using medical records for all abortion care visits in 2011 (n = 15,575) at an urban abortion provider, we determined the proportion of women who chose to view by soc...
journal_title:Contraception
pub_type: 杂志文章,多中心研究
doi:10.1016/j.contraception.2013.07.006
更新日期:2013-11-01 00:00:00
abstract::Eighty-four Chinese patients attending the Family Planning Association of Hong Kong for contraception with oral contraceptive pills were randomized into 2 groups. The first group received pills containing 0.15 mg levonorgestrel and 0.03 mg ethinyl oestradiol. The second group received pills containing 0.15 mg desogest...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(90)90126-g
更新日期:1990-01-01 00:00:00
abstract::The study of a modified minilaparotomy technique of interval female sterilization is reported. The modified minilaparotomy technique of interval female sterilization is performed under local anesthesia using the Ramathibodi uterine manipulator, bivalve speculum, and a low midline incision. Sixty cases were treated wit...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(97)00043-7
更新日期:1997-06-01 00:00:00
abstract::The effect of propanolol hydrochloride (PH) and oxprenolol hydrochloride (OH) on ovulation was studied in mature rabbits. PH-treated animals did not accept mating and ovulation was suppressed after forced mating. 5 of 6 OH-treated animals refused mating. No implantation sites or corpora lutea were found in the anim...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(75)80036-9
更新日期:1975-07-01 00:00:00
abstract:OBJECTIVE:To assess unintended pregnancy risk and associated factors among female urban Baltimore emergency department (ED) attendees. METHODS:A cross-sectional anonymous questionnaire study was completed by 790 women, sufficient to detect a 5% difference of unintended pregnancy risk in the national population and a 1...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.08.005
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Positive effects on premenstrual symptoms have been observed with low-dose oral contraceptives. Drospirenone is a synthetic progestogen with antiandrogenic and antimineralocorticoid effects. This open-label, multicenter study evaluated the effects of a combination of ethinylestradiol 30 microg and drospirenone ...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.contraception.2005.10.016
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with metabolic dysfunction and changes in cardiovascular risk markers, and using oral contraceptives (OCs) may exert a further negative effect on these alterations in patients with PCOS. Thus, the primary objective of this study was to asse...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.12.011
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the need for and outcome of self-administered medical abortion with mifepristone and misoprostol in Brazil, provided through Women on Web, a global telemedicine abortion service. STUDY DESIGN:A retrospective case review of women from Brazil who contacted Women on Web in 2011. Information from the...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.11.005
更新日期:2014-02-01 00:00:00
abstract::Forty-three homozygous (SS) female sickle cell anemic patients with a history of at least one painful crisis per month and desiring a reversible contraceptive were administered DMPA/3 months or Microgynon monthly. A third group of 16 surgically sterilized patients served as control. Patients were followed for 1 year t...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(97)00156-x
更新日期:1997-11-01 00:00:00
abstract::The present study was designed to evaluate the effectiveness of a once-weekly regimen of GnRH antagonist followed by a progestin as a potential new contraceptive method. On menstrual cycle days 2, 9, 16, and 23 (onset of menses = Day 1) monkeys were divided into two groups: 1) those injected sc with 0.1 mg/kg Nal-Glu ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(09)91007-1
更新日期:1990-06-01 00:00:00