Abstract：
:Patients taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine together with their oral contraceptive steroid may suffer contraceptive failure because of the enzyme-inducing properties of these anticonvulsants. We have examined, in six women, the effect of sodium valproate, an effective broad spectrum anticonvulsant, on the area under the plasma concentration versus time profile (AUC) of ethinyloestradiol (EE2) and levonorgestrel (Ng). Prior to sodium valproate therapy the mean AUC for EE2 was 880 +/- 109 pg/ml X h (+/- S.E.) and for levonorgestrel it was 29.1 +/- 2.9 ng/ml X h (n = 4). Between two and four months after sodium valproate therapy the mean AUC figures had not changed significantly, the figure for EE2 being 977 +/- 130 pg/ml X h and for levonorgestrel 29.2 +/- 1.9 ng/ml X h (p greater than or equal to 0.1 in each case). We conclude that sodium valproate in the dose used (200 mg b.d.) does not interact with oral contraceptive steroids.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Crawford P,Chadwick D,Cleland P,Tjia J,Cowie A,Back DJ,Orme MLdoi
10.1016/0010-7824(86)90028-4subject
Has Abstractpub_date
1986-01-01 00:00:00pages
23-9issue
1eissn
0010-7824issn
1879-0518pii
0010-7824(86)90028-4journal_volume
33pub_type
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