Safety evaluation of a male injectable antifertility agent, styrene maleic anhydride, in rats.

abstract：BACKGROUND:Whether contraception affects health-related quality of life (HRQoL) is unclear. STUDY DESIGN:We conducted a cross-sectional analysis of routine intake data collected from women aged 18-50 years, including the RAND-36 (Research and Development Corporation) measure of HRQoL, pregnancy intentions and recent c...

journal_title：Contraception

authors： Williams SL,Parisi SM,Hess R,Schwarz EB

更新日期：2012-03-01 00:00:00

abstract：:The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...

journal_title：Contraception

authors： Walling M

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Including support staff in practice change initiatives is a promising strategy to successfully implement new reproductive health services. The Resident Training Initiative in Miscarriage Management (RTI-MM) is an intervention designed to facilitate implementation of manual vacuum aspiration (MVA) for managem...

journal_title：Contraception

authors： Darney BG,VanDerhei D,Weaver MR,Stevens NG,Prager SW

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Emergency contraception (EC) does not always work. Clinicians should be aware of potential risk factors for EC failure. STUDY DESIGN:Data from a meta-analysis of two randomized controlled trials comparing the efficacy of ulipristal acetate (UPA) with levonorgestrel were analyzed to identify factors associat...

journal_title：Contraception

authors： Glasier A,Cameron ST,Blithe D,Scherrer B,Mathe H,Levy D,Gainer E,Ulmann A

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of n...

journal_title：Contraception

authors： Hampton RM,Zhang HF,Barnowski C,Wan GJ

更新日期：2008-06-01 00:00:00

abstract：:Low but rising serum human chorionic gonadotropin (hCG) levels occur infrequently after an induced abortion. Because this scenario rarely occurs after suction aspiration, clinicians may have higher suspicion for an uncommon diagnosis. The differential diagnosis includes both common and uncommon diagnoses, such as inco...

journal_title：Contraception

authors： Chen MJ,Pymar H,Creinin MD

更新日期：2018-12-01 00:00:00

abstract：:A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels i...

journal_title：Contraception

authors： Tredway DR,Mishell DR Jr

更新日期：1974-08-01 00:00:00

abstract：BACKGROUND:Tubal ligation (TL) is considered a very efficient contraceptive method. However, some patients complain of a variety of postoperative symptoms. The objective of this study was to investigate whether ovarian reserve may change after tubal ligation. STUDY DESIGN:This was a prospective cohort study of 80 fert...

journal_title：Contraception

authors： Silva AL,Ré Cd,Dietrich C,Fuhrmeister IP,Pimentel A,Corleta HV

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the effectiveness of a refined theory-based Interactive Postpartum Sexual Health Education Program to enhance postpartum women's effective contraceptive behavior. STUDY DESIGN:Participants (N=250) were randomized to three groups. Experimental Group A received our interv...

journal_title：Contraception

authors： Lee JT,Tsai JL,Tsou TS,Chen MC

更新日期：2011-07-01 00:00:00

abstract：:An injectable method of obtaining vas deferens occlusion is presented. The agent used is styrene maleic anhydride (SMA) with dimethyl sulphoxide as the solvent. The special feature of the approach is that after a period of time, spermatozoa passage is spontaneously reestablished. By varying the dose of SMA administere...

journal_title：Contraception

authors： Guha SK,Anand S,Ansari S,Farooq A,Sharma DN

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Potential barriers to intrauterine device (IUD) use include provider concern about difficult insertion, particularly for nulliparous women. OBJECTIVE:This study aims to evaluate the evidence on the effectiveness of medications to ease IUD insertion on provider outcomes (i.e., ease of insertion, need for adj...

journal_title：Contraception

authors： Zapata LB,Jatlaoui TC,Marchbanks PA,Curtis KM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In 2002, the Kaiser Foundation Health Plan in California changed its coverage policy to include 100% universal coverage for the most effective forms of contraception and for emergency contraceptive pills (ECPs). This study sought to evaluate whether removing the cost of contraception as a potential barrier t...

journal_title：Contraception

authors： Postlethwaite D,Trussell J,Zoolakis A,Shabear R,Petitti D

更新日期：2007-11-01 00:00:00

abstract：:In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...

journal_title：Contraception

authors： Shain RN

更新日期：1980-09-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamic effects of two doses of norethisterone (5mg and 3mg) used as a 'visiting pill' were investigated. There were no significant differences in the pharmacokinetics of the two doses except for the peak concentration achieved and the bioavailability as assessed by the area under the ...

journal_title：Contraception

authors： Song S,Chen JK,Yang PJ,Cheng DH,Liu WY,Fotherby K

更新日期：1986-09-01 00:00:00

abstract：:To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed ...

journal_title：Contraception

authors： Laufe LE,Sokal DC,Cole LP,Shoupe D,Schenken RS

更新日期：1996-09-01 00:00:00

abstract：:Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasia...

journal_title：Contraception

authors： Nieschlag E

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:To explore perspectives on family planning among young people who perceive they are infertile or will have difficulty carrying a pregnancy to term owing to medical conditions or procedures. METHODS:This exploratory analysis examined pregnancy plans and contraceptive behavior among 12 young adults with a diag...

journal_title：Contraception

authors： Gomez AM,Arteaga S,Ingraham N,Arcara J

更新日期：2019-07-01 00:00:00

abstract：:The purpose of the study was to evaluate semen quality in young Chinese men and to establish reference values. Normal healthy young men from seven geographical areas were enrolled. The study showed that the mean sperm volume was 2.61 mL, and mean percent of sperm with forward progression was 59.89, while median of sem...

journal_title：Contraception

authors： Junqing W,Qiuying Y,Jianguo T,Wei Y,Liwei B,Yuxian L,Yumei Z,Kangshou Y,Weiqun L,Lu C,Ersheng G

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:This study was conducted to assess the efficacy and incidence of side effects of a regimen of repeated doses of 400 microg sublingual misoprostol for termination of pregnancy of <7 weeks gestation. METHOD:Fifty women were given 400 microg sublingual misoprostol every 3 h for three doses. Two additional dose...

journal_title：Contraception

authors： Cheung W,Tang OS,Lee SW,Ho PC

更新日期：2003-08-01 00:00:00

abstract：:This communication is to report the effects of gossypol on the synthesis of chromosomal basic proteins in the spermiogenic cells. A double-labelling experiment has been performed. The control rats received 14C-arginine, whereas the gossypol-treated rats received a 3H-arginine injection. An equal volume of the tissues ...

journal_title：Contraception

authors： Teng CS,Fei RR

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasoni...

journal_title：Contraception

authors： Borgatta L,Betstadt SJ,Reed A,Feng KT

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To determine the pharmacokinetics (PK) of drospirenone (DRSP), alone versus in combination with ethinyl estradiol (EE), after single and repeated administration. STUDY DESIGN:We conducted a single-centre, open-label, crossover, 2-treatment, 2-period, 2-sequence study in which non-micronized DRSP 4 mg or a co...

journal_title：Contraception

authors： Richter WH,Koytchev R,Kirkov V,Merki G,Colli E,Regidor PA

更新日期：2020-02-01 00:00:00

abstract：:Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm o...

journal_title：Contraception

authors： Coutinho EM,de Souza JC,Athayde C,Barbosa IC,Alvarez F,Brache V,Gu ZP,Emuveyan EE,Adekunle AO,Devoto L,Shaaban MM,Salem HT,Affandi B,de Acosta OM,Mati J,Ladipo OA

更新日期：1996-02-01 00:00:00

abstract：:To evaluate a potential bias between methods of birth control used and prescribed by physicians, we surveyed sexually active female physicians in regards to their own methods of birth control. When the contraceptive practices of female physicians are compared to those of the general population, no difference in use of...

journal_title：Contraception

authors： Zbella EA,Vermesh M,Gleicher N

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the impact of a scholarly concentration for medical students, which aims to develop students' research, clinical and advocacy skills to promote women's reproductive health. STUDY DESIGN:Scholarly concentration programs provide opportunities to engage in scholarship beyond the traditional medical...

journal_title：Contraception

authors： Nothnagle M,Radlinski H,Magee SR,Allen RH

更新日期：2014-11-01 00:00:00

abstract：:In a prospective, randomised dose-finding study involving 60 women scheduled for termination of 1st trimester pregnancy, 25 micrograms, 50 micrograms or 100 micrograms of a sulprostone gel with a constant injection volume of 2.5 ml were applied intracervically 6-8 hours before curettage. The gelatinising agent was Plu...

journal_title：Contraception

authors： Rath W,Dennemark N,Gödicke HD

更新日期：1985-03-01 00:00:00

abstract：:The long-term effects of tolnidamine on male reproduction and general body metabolism were studied in rabbits (Oryctolagus cuniculus). The study was divided into three groups of 10 animals each. The first group (A) received vehicle alone to serve as controls. The second and third groups (B and C) of animals were admin...

journal_title：Contraception

authors： Ansari AS,Kumar Y,Srivastava S,Lohiya NK

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:The study was conducted to determine the impact of switching from oral to transdermal patch or vaginal ring contraception on biomarkers of thrombosis. STUDY DESIGN:Current healthy oral contraceptive (OC) users were randomized to switch to either a contraceptive ring (CR) or patch (CP) and underwent phleboto...

journal_title：Contraception

authors： Jensen JT,Burke AE,Barnhart KT,Tillotson C,Messerle-Forbes M,Peters D

更新日期：2008-12-01 00:00:00

abstract：:To describe surface abnormalities found by scanning electron microscopy of non-lubricated latex condoms, thirty samples of 15 condoms were photographed at low (26-94x), medium (240-940x) and high (> 1000x) magnification. Each sample was initially scanned at low magnification to determine the presence and location of s...

journal_title：Contraception

authors： Rosenzweig BA,Even A,Budnick LE

更新日期：1996-01-01 00:00:00

abstract：:For a dilation and evacuation (D&E) procedure, the cervix must be dilated sufficiently to allow passage of operative instruments and products of conception without injuring the uterus or cervical canal. Preoperative preparation of the cervix reduces the risk of cervical laceration and uterine perforation. The cervix m...

journal_title：Contraception

authors： Fox MC,Krajewski CM

更新日期：2014-02-01 00:00:00