Abstract：
:The pharmacokinetics and pharmacodynamic effects of two doses of norethisterone (5mg and 3mg) used as a 'visiting pill' were investigated. There were no significant differences in the pharmacokinetics of the two doses except for the peak concentration achieved and the bioavailability as assessed by the area under the serum norethisterone concentration - time curve. Both doses were rapidly absorbed. Pharmacodynamic effects were minor. No change occurred in serum concentrations of total cholesterol, total triglycerides or HDL-cholesterol. The area under the serum glucose concentration--time curve and particularly the area under the serum insulin concentration--time curve were significantly increased as a result of treatment but no change occurred in the serum levels of glycosylated haemoglobin. SHBG concentrations in serum decreased on treatment whereas those of ceruloplasmin increased.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Song S,Chen JK,Yang PJ,Cheng DH,Liu WY,Fotherby Kdoi
10.1016/0010-7824(86)90008-9subject
Has Abstractpub_date
1986-09-01 00:00:00pages
269-82issue
3eissn
0010-7824issn
1879-0518pii
0010-7824(86)90008-9journal_volume
34pub_type
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