Rheological properties of contraceptive gels.

Abstract:

:The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II, and Advantage-S included stress growth, stress relaxation and residual stress, and the shear rate dependence of viscosity. All gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity. Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant.

journal_name

Contraception

journal_title

Contraception

authors

Owen DH,Peters JJ,Katz DF

doi

10.1016/s0010-7824(00)00184-0

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

321-6

issue

6

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(00)00184-0

journal_volume

62

pub_type

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