Abstract:
:The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II, and Advantage-S included stress growth, stress relaxation and residual stress, and the shear rate dependence of viscosity. All gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity. Conceptrol and Gynol II had no residual stress, while both KY Plus and Advantage-S did. The gels differed in their response to dilution with vaginal fluid simulant.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Owen DH,Peters JJ,Katz DFdoi
10.1016/s0010-7824(00)00184-0subject
Has Abstractpub_date
2000-12-01 00:00:00pages
321-6issue
6eissn
0010-7824issn
1879-0518pii
S0010-7824(00)00184-0journal_volume
62pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract::Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90003-7
更新日期:1980-03-01 00:00:00
abstract::Interception of pregnancy in its initial stage is an attractive and viable approach to contraception. A chemical agent, taken within the first few days of missed menses, intercepts the conception, which is expelled with menstrual flow. The main targets of such agents are the uterus, blastocyst and the growing trophobl...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.12.011
更新日期:2004-05-01 00:00:00
abstract:PURPOSE:This prospective observational study evaluated the bleeding patterns of adolescents receiving a monthly injectable contraceptive containing norethisterone enanthate 50 mg plus estradiol valerate 5 mg. MATERIALS AND METHODS:The study enrolled 73 volunteers aged between 14 and 19 years; of these patients, 38 (52...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2006.01.009
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:The FDA approval of mifepristone in 2000 broadened the available options for abortion. The aim of this study was to evaluate whether physicians in New Mexico have integrated the use of mifepristone into their practice. STUDY DESIGN:We performed a mail-out survey of New Mexico Obstetrician Gynecologists (Ob-...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.11.021
更新日期:2011-08-01 00:00:00
abstract::This investigation describes the synthesis of a biodegradable hydrogel composed of a core surrounded by four concentric sheaths containing dextran, copolymers of polylactide and epsilon-caprolactone. The hydrogel was impregnated with iron (II) d-gluconate dihydrate, which causes complete spermiostasis due to lipid per...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2004.02.015
更新日期:2004-09-01 00:00:00
abstract::The aim of this study was to characterize the bleeding pattern, the outcome of pregnancies and the levonorgestrel plasma levels associated with method failures in Norplant implants users. Nineteen pregnancies are reported in 458 woman and 21,589 woman-months observed during the first eight years of Norplant use. Pregn...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90096-x
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND:There is a lack of information concerning the decision factors and sources of information influencing women who purposefully deviate from the prescribed use of their combined hormone contraceptives to exert elective control of their scheduled bleeding. STUDY DESIGN:A self-administered email survey of schedu...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2012.12.012
更新日期:2013-09-01 00:00:00
abstract::A questionnaire study was carried out to investigate the needs of women undergoing a medical abortion induced by mifepristone in combination with either gemeprost pessaries or oral misoprostol. One-hundred-and-eighty women undergoing medical abortion of pregnancy of up to 63 days amenorrhoea were randomised to treatme...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(92)90147-l
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Given the need for a 90-day post-Essure hysterosalpingogram (HSG) to confirm proper tubal placement and occlusion, we examined the impact of dedicating a staff nurse to schedule HSG appointments, call with appointment reminders and track HSG compliance for patients who had Essure. STUDY DESIGN:We performed ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2010.01.019
更新日期:2010-06-01 00:00:00
abstract::Presumably, Latino women engage in little family planning because of religious or cultural objections to contraception. The purpose of this study was to examine how acculturation, religion and various demographic factors were related to the family-planning behaviors of Latino women in the United States. Data were coll...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2003.10.011
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:This study investigated the effects of adding levomefolate calcium 0.451 mg (the calcium salt of L-5-methyltetrahydrofolate; Metafolin®) to an oral contraceptive containing ethinylestradiol (EE) 20 mcg/drospirenone (drsp) 3 mg on folate levels in healthy women seeking contraception. STUDY DESIGN:In this ran...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2011.05.013
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:This prospective study aimed to assess the possible effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and fasting blood glucose levels over a period of 1 year. METHODS:Forty-eight premenopausal women, attending our gynecology clinic with the complaint of menorrhagia, were en...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.12.005
更新日期:2006-05-01 00:00:00
abstract::The relationship between intrauterine device (IUD) use and the development of endometrial cancer was assessed in data from seven countries that were collected between 1979 and 1988 for a multinational hospital-based case-control study. Two hundred twenty-six cases of endometrial cancer were compared with 1,529 control...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(96)00199-0
更新日期:1996-12-01 00:00:00
abstract::The objective of this study was to describe the availability of early surgical and medical abortion among members of the National Abortion Federation (NAF) and to identify factors affecting the integration of early abortion services into current services. Telephone interviews were conducted with staff at 113 Planned P...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00512-7
更新日期:2003-04-01 00:00:00
abstract::Primary cultures of rat Leydig and Sertoli cells were used to evaluate the direct effects of GTW on testicular cells and to compare these to the effects of gossypol acetate. Both GTW and gossypol acetate can affect the survival of Leydig and Sertoli cells. But Sertoli cells are much more sensitive than Leydig cells, e...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(92)90069-6
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Hypertension is recognized as a major risk factor for coronary, cerebral and renal vascular disease. Hormonal methods of contraception may increase the risk for cardiovascular events. We evaluated whether the combined hormonal contraceptive vaginal ring that releases 15-mcg ethinylestradiol and 120 mcg of et...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.04.003
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:This study is designed to evaluate the popularity of vasectomy in Iran. The study was conducted to calculate the frequency of vasectomy over time, to compare vasectomy users' characteristics with the general population and whether these characteristics have changed over time. STUDY DESIGN:A cross-sectional ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.07.010
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To determine if laparoscopic sterilization using the Filshie clip causes less postoperative pain as compared to the Falope ring during the first 24 h after surgery. STUDY DESIGN:Forty subjects were enrolled. Five milliliters of 0.5% bupivicaine was injected at each of the two incision sites and 5 mL was drip...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.contraception.2003.09.014
更新日期:2004-02-01 00:00:00
abstract::For a dilation and evacuation (D&E) procedure, the cervix must be dilated sufficiently to allow passage of operative instruments and products of conception without injuring the uterus or cervical canal. Preoperative preparation of the cervix reduces the risk of cervical laceration and uterine perforation. The cervix m...
journal_title:Contraception
pub_type: 杂志文章,实务指引
doi:10.1016/j.contraception.2013.11.001
更新日期:2014-02-01 00:00:00
abstract::Combination oral contraceptive (COC) users have reduced risks of ovarian and endometrial cancer, but COCs have not reduced breast cancer risk. We have previously argued that a hormonal contraceptive with substantially lower doses of sex-steroids should reduce breast cancer risk by decreasing the breast epithelial cell...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90095-o
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.08.009
更新日期:2015-01-01 00:00:00
abstract::One-hundred-thirty of 178 women who received Norplant-2 implants were followed prospectively for 4 years. Menstrual disorders were the most common reason for discontinuation. Only one patient conceived, for a failure rate of 0.6%. ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(01)00265-7
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:As part of a strategy to revitalize postpartum family planning services, Government of India revised its policy in 2013 to permit trained nurses and midwives to insert postpartum intrauterine contraceptive devices (PPIUCDs). This study compares two key outcomes of PPIUCD insertions--expulsion and infection--f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.12.012
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The SILCS diaphragm is a new, single-size contraceptive diaphragm. The objective of this crossover pilot study was to assess the fit and acceptability of the SILCS diaphragm compared to the Ortho ALL-FLEX diaphragm to validate the product design among parous women in a low-resource setting. STUDY DESIGN:Sex...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2008.07.001
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Questions remain regarding whether oral contraceptive (OC) use among women with a family history of breast cancer increases disease risk. STUDY DESIGN:We conducted a systematic review by searching MEDLINE and CENTRAL databases for evidence (in all languages) published in peer-reviewed journals from 1966 to ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2009.04.010
更新日期:2009-10-01 00:00:00
abstract::Histopathological and biochemical effects of gossypol acetate (GA) on pituitary-gonadal axis were investigated. 10 and 25 mg GA/kg were administered orally to sexually mature adult male Wistar rats for 4 and 5 weeks, respectively. STH and LTH/PRL cells showed no significant changes as compared to those of controls whi...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(92)90162-m
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVE:While the intra-uterine device (IUD) is the second most popular contraceptive method in France, its use remains low among women most at risk of unintended pregnancies. Acknowledging the conjoint role of women and physicians in contraceptive decision making, we investigate the determinants of IUD use and IUD r...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.10.003
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2010.04.013
更新日期:2010-10-01 00:00:00
abstract::Blood pyrodoxine hydrochloride (vitamin-B6) concentration was determined in 50 women using combined oral contraceptives (OCs), 24 women who received an intramuscular injection of 150 mg medroxyprogesterone acetate (MPA) every 12 weeks, and in 14 women who used an intrauterine device (IUD) at the out-patient contracep...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(74)90078-x
更新日期:1974-04-01 00:00:00
abstract::The presence of medical conditions that might affect the use of depot-medroxyprogesterone acetate (DMPA) as a contraceptive method was assessed in a rural district in Nepal. A general health survey was conducted in nonpregnant and noncontracepting women aged 15-44 years to determine the presence of any health problems...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(99)00056-6
更新日期:1999-07-01 00:00:00