Abstract：
:This investigation describes the synthesis of a biodegradable hydrogel composed of a core surrounded by four concentric sheaths containing dextran, copolymers of polylactide and epsilon-caprolactone. The hydrogel was impregnated with iron (II) d-gluconate dihydrate, which causes complete spermiostasis due to lipid peroxidation, ascorbic acid to increase the viscosity of the cervical mucus and mixtures of polyamino and polycarboxylic acids to sustain vaginal pH close to 4.5. The combined effects of the agents in the daily eluates of the hydrogel were efficacious up to 16 days, within 30 s, as shown by sperm penetration tests. For in vivo studies, rabbits were chosen as the experimental model because they are easy to handle and the female is always in estrus. The anterior vagina of estrous female rabbits was instilled with the hydrogel, and then inseminated with the semen from a fertile male. Postinsemination flush from the female rabbits showed that all of the sperm were dead. These observations demonstrate the potential for the development of a biocompatible, nonhormonal, intravaginal contraceptive device.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Saxena BB,Singh M,Gospin RM,Chu CC,Ledger WJdoi
10.1016/j.contraception.2004.02.015subject
Has Abstractpub_date
2004-09-01 00:00:00pages
213-9issue
3eissn
0010-7824issn
1879-0518pii
S0010782404000800journal_volume
70pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：OBJECTIVES:This study is designed to evaluate the popularity of vasectomy in Iran. The study was conducted to calculate the frequency of vasectomy over time, to compare vasectomy users' characteristics with the general population and whether these characteristics have changed over time. STUDY DESIGN:A cross-sectional ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.07.010
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:This study aims to clarify the associations between mobile phone ownership use on family planning outcomes. Secondary analysis of DHS data finds that in certain contexts, mobile phone ownership may be related to increased FP uptake. STUDY DESIGN:Using recent data for women 15-49 from the Demographic and Hea...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.10.004
更新日期：2020-02-01 00:00:00
abstract：:The purpose of the study was to evaluate semen quality in young Chinese men and to establish reference values. Normal healthy young men from seven geographical areas were enrolled. The study showed that the mean sperm volume was 2.61 mL, and mean percent of sperm with forward progression was 59.89, while median of sem...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00281-0
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.01.009
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:This study was conducted to assess the potential impact of an unintended pregnancy on women's quality of life. STUDY DESIGN:We asked 192 nonpregnant women to report how they would feel if they learned that they were pregnant using a visual analog scale (VAS), a time trade-off (TTO) metric, a standard gamble...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2008.04.120
更新日期：2008-09-01 00:00:00
abstract：:A large international multi-center IUD data set (N = 5520) coordinated by Family Health International was analysed to determine if the uterine position of a woman (anteverted, mid-positioned or retroverted) affects the ease of IUD insertion and if knowledge of uterine position would diminish insertion-related problems...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0010-7824(90)90059-5
更新日期：1990-05-01 00:00:00
abstract：:Barrier contraceptive trials and disease intervention studies often utilize coital diaries to measure sexual exposures: dates and frequency of intercourse, product use, additional or alternative contraceptive use, and menstrual bleeding. The validity of these self-reported data is a matter of debate, but if used, bett...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(01)00183-4
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:The purpose of this pilot project was to test the feasibility of a technique designed to place a copper intrauterine device (IUD) through the hysterotomy incision of an elective cesarean delivery to minimize possible contamination and to guarantee that tailstrings were visible in the vagina for easy removal ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.01.014
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Questions remain regarding whether oral contraceptive (OC) use among women with a family history of breast cancer increases disease risk. STUDY DESIGN:We conducted a systematic review by searching MEDLINE and CENTRAL databases for evidence (in all languages) published in peer-reviewed journals from 1966 to ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2009.04.010
更新日期：2009-10-01 00:00:00
abstract：:A prospective, randomized clinical trial observed the effects of Norplant long-term contraceptive implants and domestic implants similar to Norplant on bone mineral density and bone metabolism in female acceptors for 1 year. Bone mineral density (BMD) and bone mineral content (BMC) of lumbar 2-4 and proximal femur of ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(99)00080-3
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasoni...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/j.contraception.2009.12.001
更新日期：2010-04-01 00:00:00
abstract：:A study was performed to evaluate the impact of knowledge of HIV infection (diagnosis) on contraception information and choices for HIV infected women. A questionnaire was given to 140 HIV infected women. Most of the studied population included young women with a low educational level. A significant increase in the kn...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00332-3
更新日期：2002-08-01 00:00:00
abstract：:The study compares NORPLANT subdermal implants acceptors enrolled randomly for two different insertion procedures. One group (420 women) received the implants with the use of a scalpel according to the manufacturer's instructions. The other group (423 women) received the implant without an incision, directly through a...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(91)90013-6
更新日期：1991-09-01 00:00:00
abstract：:Saponins isolated from Sapindus mukorossi have potent spermicidal activity. Morphological changes in human ejaculated spermatozoa after exposure to these saponins were evaluated under Scanning Electron Microscope. The minimum effective concentration (0.05% in spot test) did not affect the surface topography after expo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(89)90111-x
更新日期：1989-05-01 00:00:00
abstract：:Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weekly for a period of 12 weeks by measuring 3 pituitary hormones (FSH, LH and prolactin) and 2 ovarian hormones (oestradiol 17-B and progesterone). It was concluded that NET-OEN is a...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(83)80004-3
更新日期：1983-07-01 00:00:00
abstract：OBJECTIVES:The present study aims to prospectively evaluate quality of life (QoL) of women using 52-mg levonorgestrel intrauterine system (LNG-IUS) for contraception determined through the Sociedad Española de Contracepción (Spanish contraception Society) (SEC)-QoL, a questionnaire specifically designed to assess the i...
journal_title：Contraception
pub_type： 杂志文章,多中心研究
doi：10.1016/j.contraception.2015.12.014
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:The use of progestogen-only contraceptives by breastfeeding women raises theoretical concerns regarding possible adverse effects on breastfeeding success, and infant health or growth. This review was conducted to determine from the literature whether use of progestogen-only contraceptives by breastfeeding wo...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2010.02.002
更新日期：2010-07-01 00:00:00
abstract：:Open-ended vasectomy was performed on one-hundred men. Sixty-three of them showed up for follow-up six months later. Spontaneous recanalisation had occurred in two. Sperm granuloma without orchialgia was found in 14 out of 59 men (23.9%). Twenty-one out of the 63 thought their sex life had improved, while 40 thought i...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(86)90040-5
更新日期：1986-06-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to provide evidence about the mechanism of action of the Yuzpe method of emergency contraception by examining effectiveness by cycle day of intercourse relative to ovulation. METHODS:Through a literature search, we identified eight studies that present the number of women treate...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00486-9
更新日期：2003-03-01 00:00:00
abstract：:We evaluated the efficacy and side effects of immediate postcoital administration of levonorgestrel 0.75 mg used repeatedly for contraception. A total of 295 healthy women with infrequent coitus were enrolled at 6 study sites. Each woman took levonorgestrel 0.75 mg by mouth immediately after intercourse during 6 month...
journal_title：Contraception
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVE:To describe the role of worksite characteristics, job role and abortion stigma in clinical abortion workers' occupational stress. STUDY DESIGN:We recruited nurses, medical assistants and counseling staff who provide abortion care at five hospitals and four freestanding clinics in Massachusetts. Study instrum...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.07.003
更新日期：2018-12-01 00:00:00
abstract：:The ability of 40 mg of milled suspension of a new long-acting androgen ester (20 Aet-1) to restore and maintain accessory gland function was compared with that of testosterone enanthate (TE) in castrated adult rhesus monkeys. Castration did not abolish the ejaculatory response since only two animals did not void seme...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(91)90129-4
更新日期：1991-01-01 00:00:00
abstract：:The effect of propanolol hydrochloride (PH) and oxprenolol hydrochloride (OH) on ovulation was studied in mature rabbits. PH-treated animals did not accept mating and ovulation was suppressed after forced mating. 5 of 6 OH-treated animals refused mating. No implantation sites or corpora lutea were found in the anim...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(75)80036-9
更新日期：1975-07-01 00:00:00
abstract：:DL111-IT, a non-hormonal contragestional agent, revealed synergistic effects in combination with mifepristone (RU486) in some species. The present study was undertaken to clarify the role of DL111-IT when used alone or plus RU486 on uterine polyamines biosynthesis, histologic alteration of decidual cells, and antifert...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00197-4
更新日期：2001-05-01 00:00:00
abstract：:The incidence of Candida albicans (C.A.) infection of the vagina was evaluated in vaginal discharges obtained from 85 subjects using a large battery of culture media and confirmatory tests. Twenty women using DMPA 150 mg i.m. contraceptive injections for more than one year (long-term users) were compared with forty 2n...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(79)90082-9
更新日期：1979-08-01 00:00:00
abstract：:Intrauterine devices (IUD) provide effective contraception. The current study evaluates the concentration of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the intrauterine fluid of postmenopausal women using an intrauterine delivery system releasing progesterone (IDS-P). Intrauterine fluid was ob...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(99)00014-1
更新日期：1999-03-01 00:00:00
abstract：:The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(94)90033-7
更新日期：1994-04-01 00:00:00
abstract：OBJECTIVES:The aim of this survey was to understand US women's contraception journey from her first prescribed method to her current one including reasons for choosing and stopping/switching methods, healthcare provider relationships, and bleeding preferences. STUDY DESIGN:We administered a nationally-representative, ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.09.010
更新日期：2018-03-01 00:00:00
abstract：:A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels i...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90071-7
更新日期：1974-08-01 00:00:00
abstract：:In 1991, the source of public sector condom supplies in an African country changed from USAID to WHO. Following a complaint, the two types of condoms were sampled and compared. Laboratory tests indicated that the new-style condoms were of adequate quality, but a number of differences were noted between the two types. ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(95)00183-b
更新日期：1995-10-01 00:00:00
