当前位置： SCI文献检索 > CONTRACEPTION期刊下所有文献 > The protective influence of progestogen only contraception against vaginal moniliasis.

The protective influence of progestogen only contraception against vaginal moniliasis.

Abstract：

:The incidence of Candida albicans (C.A.) infection of the vagina was evaluated in vaginal discharges obtained from 85 subjects using a large battery of culture media and confirmatory tests. Twenty women using DMPA 150 mg i.m. contraceptive injections for more than one year (long-term users) were compared with forty 2nd trimester pregnant cases with respect to vaginal candidiasis. The basis of comparison was the presence of amenorrhea and high hormonal levels in both groups. However, pregnant subjects showed a 60% prevalence while none of the DMPA cases had a positive culture or smear. Another group of 25 cases was similarly studied once before DMPA injection and again three months following drug administration (short-term use). The pre-therapy samples demonstrated a 32% incidence which was reduced to 8% after three months of use. It therefore appears that progestogen only contraceptives have the advantage of some protective influence against monilial vaginitis. Moreover, the use of these drugs may carry the beneficial potential of use in resistant cases of monilial vaginitis, either as a single approach or better as a supplementary procedure to known antifungal agents. :The incidence of vaginal moniliasis in women accepting Depo-Provera (DMPA) as a contraceptive method was determined, and differences in incidence between long- and short-term users were investigated. 85 reproductive age women were divided into 3 groups: 1) 40 second-trimester pregnant women; 2) 20 DMPA users for more than 1 year (long-term users); and 3) 25 women accepting DMPA for the 1st time. Among the 85 cases studied, moniliasis was recovered from the vaginal smears of 34 (40%). The highest occurrence was among Group 1, where out of the 40 cases, 24 (60%) had Candidia in their vaginal secretions. On the other hand, from the 25 Group 3 cases, Candida was recovered from 8 (32%) before administration of DMPA. 3 months later, Candida was only recovered from 2 (8%) of the same Group 3 subjects. This occurrence in the follow-up examination (8%) was significantly lower than the control sample before drug administration (Z=2.12). Apparently, incidence of moniliasis decreased with short-term DMPA use. None of the 20 long-term users had Candida in their vaginal secretions. Culture technique was superior to smear technique for determining Candida; all cases diagnosed by smear were culture positive, whereas smear positive cases in Groups 1 and 3 composed only 83.3% of culture positive cases in both groups.

journal_name

Contraception

journal_title

Contraception

authors

Toppozada M,Onsy FA,Fares E,Amir S,Shaala S

doi

10.1016/0010-7824(79)90082-9

subject

Has Abstract

pub_date

1979-08-01 00:00:00

pages

99-103

issue

eissn

0010-7824

issn

1879-0518

pii

0010-7824(79)90082-9

journal_volume

pub_type

杂志文章

在线工具

The protective influence of progestogen only contraception against vaginal moniliasis.