Abstract：
:This randomized, double-blind, placebo-controlled exploratory study examined the efficacy and safety of a low-dose oral contraceptive (Mircette), desogestrel/ethinyl estradiol [DSG/EE] and ethinyl estradiol [EE]) in relieving the symptoms of dysmenorrhea. Twenty-three clinics in the United States enrolled 77 women (age < or =32 years) with primary dysmenorrhea documented for at least four consecutive cycles. Forty participants received DSG/EE&EE and 37 received placebo for four consecutive 28-day cycles. The intensity of menstrual-related distress was measured with the Menstrual Distress Questionnaire (MDQ). Patient diaries were used to assess number of school/work days missed as well as the use of rescue medication. Participants receiving DSG/EE&EE recorded reduced menstrual pain severity, lower total MDQ scores, and significantly less menstrual cramping. No significant change in bloating, anxiety, loneliness, weight gain, or acne was reported. The DSG/EE&EE formulation shows promise for the treatment of primary dysmenorrhea and was well tolerated by the participants in this study.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Hendrix SL,Alexander NJdoi
10.1016/s0010-7824(02)00414-6subject
Has Abstractpub_date
2002-12-01 00:00:00pages
393-9issue
6eissn
0010-7824issn
1879-0518pii
S0010782402004146journal_volume
66pub_type
临床试验,杂志文章,随机对照试验相关文献
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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