The efficacy and acceptability of a low-dose levonorgestrel intravaginal ring for contraception in a UK cohort.

Abstract:

:The efficacy and acceptability of a levonorgestrel-releasing intravaginal ring (IVR) for contraception was assessed in a British cohort studied as part of a multicentre, multinational clinical trial performed under the auspices of the World Health Organisation. One-hundred-and-fifty women took part in the study in two UK centres and completed 1417.5 months of method use. Fifty-nine women discontinued use of the IVR before the end of one year giving an overall discontinuation rate of 39.9 per 100 woman-years. The discontinuation for pregnancy with the ring in situ, was 3.0 per 100 woman-years (life table analysis). Menstrual disturbance, vaginal problems and involuntary expulsion resulted in discontinuation rates of 8.9, 8.4 and 1.6 per 100 woman-years, respectively. This method is an acceptable and effective method of contraception for women.

journal_name

Contraception

journal_title

Contraception

authors

Elder MG,Lawson JP,Elstein M,Nuttall ID

doi

10.1016/0010-7824(91)90040-m

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

129-37

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010-7824(91)90040-M

journal_volume

43

pub_type

临床试验,杂志文章,多中心研究
  • Increased exposure of norethindrone in HIV+ women treated with ritonavir-boosted atazanavir therapy.

    abstract:OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.08.009

    authors: DuBois BN,Atrio J,Stanczyk FZ,Cherala G

    更新日期:2015-01-01 00:00:00

  • A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy.

    abstract::This was a double-blind randomized control study to evaluate the efficacy of cervical priming by nitric oxide donor before second-trimester induced abortion. One-hundred healthy women with a singleton pregnancy between 14 and 20 weeks of gestation were randomized into either 40 mg isosorbide mononitrate or placebo, gi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(03)00170-7

    authors: Li CF,Chan CW,Ho PC

    更新日期:2003-10-01 00:00:00

  • Severity of infection following the introduction of new infection control measures for medical abortion.

    abstract:BACKGROUND:In response to concerns about serious infections following medical abortion, in early 2006 the Planned Parenthood Federation of America changed the route of misoprostol administration from vaginal to buccal and required either routine antibiotic coverage or universal screening and treatment for chlamydia; in...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.08.022

    authors: Fjerstad M,Trussell J,Lichtenberg ES,Sivin I,Cullins V

    更新日期:2011-04-01 00:00:00

  • Evaluation of the effect of a patient decision aid about vasectomy on the decision-making process: a randomized trial.

    abstract:BACKGROUND:Between 7% and 10% of men who choose vasectomy as a contraceptive method regret their decision. This study evaluates the effect of a patient decision aid (PtDA) designed to help men decide whether or not to have a vasectomy. STUDY DESIGN:Men considering vasectomy were randomized to an experimental group tha...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.05.003

    authors: Labrecque M,Paunescu C,Plesu I,Stacey D,Légaré F

    更新日期:2010-12-01 00:00:00

  • The zoapatle V--the effect of kauradienoic acid upon uterine contractility.

    abstract::Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90005-7

    authors: Lozoya X,Enríquez RG,Bejar E,Estrada AV,Girón H,Ponce-Monter H,Gallegos AJ

    更新日期:1983-03-01 00:00:00

  • Knowledge of the risks and benefits associated with oral contraception in a university-aged sample of users and non-users.

    abstract::As research has shown that knowledge concerning the health risks and benefits of oral contraceptive (OC) use is a contributor to OC compliance, the following study examined an educated sample of young women to determine the level of knowledge concerning the risks and benefits of OC use. A 28-item questionnaire was dev...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00194-9

    authors: Bryden PJ,Fletcher P

    更新日期:2001-04-01 00:00:00

  • A new experimental three-dimensional, reticular intrauterine device (3-DRIUD) composed of nitinol and silicone rubber.

    abstract:BACKGROUND:The aim of this study was to explore a new three-dimensional, reticular intrauterine device (3-DRIUD) composed of nitinol and silicone rubber and to observe the contraceptive effect of the device in rats. STUDY DESIGN:Two contraceptive experiments were performed. In the first, female rats underwent bilatera...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.10.031

    authors: Qiu Y,Wang LG,Zhang MH,Zhang YP,Zhang AD,Yang DT

    更新日期:2013-07-01 00:00:00

  • Progestin-only pill use and pill switching during breastfeeding.

    abstract::The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...

    journal_title:Contraception

    pub_type: 社论

    doi:10.1016/0010-7824(95)00076-m

    authors: Visness CM,Rivera R

    更新日期:1995-05-01 00:00:00

  • Relationship of intraamniotic digoxin to fetal demise.

    abstract:BACKGROUND:Induced fetal demise by intraamniotic injection of digoxin is an alternative to methods using intracardiac or umbilical vein injection. This study was designed to evaluate the effectiveness of intraamniotic injection and the timing of fetal demise after injection. STUDY DESIGN:Twenty-two women had ultrasoni...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2009.12.001

    authors: Borgatta L,Betstadt SJ,Reed A,Feng KT

    更新日期:2010-04-01 00:00:00

  • Advancing non-directive pregnancy options counseling skills: A pilot Study on the use of blended learning with an online module and simulation.

    abstract:OBJECTIVE:Limitations on didactic time pose barriers to teaching non-directive pregnancy options counseling. This study set out to explore the use of an online module to support trainee performance in a pregnancy options counseling standardized-patient exercise implemented among third-year medical students, and to exam...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.03.005

    authors: Lupi C,Ward-Peterson M,Chang W

    更新日期:2016-10-01 00:00:00

  • Apoptosis occurs in implantation site of the rhesus monkey during early stage of pregnancy.

    abstract::The exact role of apoptosis that occurs in human placenta during the early stage of pregnancy remains unknown because of the difficulty in obtaining the intact implantation site. In this study, we used rhesus monkey as an animal model to examine apoptosis occurring in the implantation site at various stages of early p...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00241-4

    authors: Fei G,Peng W,Xin-Lei C,Zhao-Yuan H,Yi-Xun L

    更新日期:2001-09-01 00:00:00

  • Profile of women presenting for abortions in Singapore at the National University Hospital.

    abstract::The study was conducted to profile women seeking abortions at the National University Hospital, with particular interest in the trend of teenage pregnancies with the aim of identifying risk factors for late presentation for abortions. All patients who underwent an abortion at our center from January 1, 1996 to Decembe...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00317-7

    authors: Singh K,Fong YF,Loh SY

    更新日期:2002-07-01 00:00:00

  • A comparative study of a progestin-only oral contraceptive versus non-hormonal methods in lactating women in Buenos Aires, Argentina.

    abstract::A non-randomized comparative clinical trial of the progestin-only oral contraceptive (POC), Ovrette (75 mcg norgestrel) (Wyeth), versus non-hormonal methods was conducted at two clinics in Buenos Aires, Argentina. The trial was designed to assess the breast-feeding patterns of women choosing progestin-only oral contra...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(91)90104-n

    authors: Moggia AV,Harris GS,Dunson TR,Diaz R,Moggia MS,Ferrer MA,McMullen SL

    更新日期:1991-07-01 00:00:00

  • A prospective, non-randomized study of home use of mifepristone for medical abortion in the U.S.

    abstract:OBJECTIVE:To determine the acceptability of taking mifepristone at home for early medical abortion in the United States. STUDY DESIGN:This prospective, non-randomized, open-label study at six Planned Parenthood centers gave women with pregnancies up to 63 days' gestation seeking medical abortion the choice of taking m...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.contraception.2015.06.026

    authors: Chong E,Frye LJ,Castle J,Dean G,Kuehl L,Winikoff B

    更新日期:2015-09-01 00:00:00

  • Interleukin-6 and tumor necrosis factor-alpha concentrations in the intrauterine cavity of postmenopausal women using an intrauterine delivery system releasing progesterone. A possible mechanism of action of the intrauterine device.

    abstract::Intrauterine devices (IUD) provide effective contraception. The current study evaluates the concentration of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the intrauterine fluid of postmenopausal women using an intrauterine delivery system releasing progesterone (IDS-P). Intrauterine fluid was ob...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(99)00014-1

    authors: Archer DF,DeSoto KR,Baker JM

    更新日期:1999-03-01 00:00:00

  • TSPY4 is a novel sperm-specific biomarker of semen exposure in human cervicovaginal fluids; potential use in HIV prevention and contraception studies.

    abstract:BACKGROUND:Developing an objective, reliable method to determine semen exposure in cervicovaginal fluids is important for accurately studying the efficacy of vaginal microbicides and contraceptives. Y-chromosome biomarkers offer better stability, sensitivity, and specificity than protein biomarkers. TSPY4 belongs to th...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.11.022

    authors: Jacot TA,Zalenskaya I,Mauck C,Archer DF,Doncel GF

    更新日期:2013-09-01 00:00:00

  • Comprehensive analysis of the use of pre-procedure ultrasound for first- and second-trimester abortion.

    abstract:BACKGROUND:The use of ultrasound (US) is common in some settings before an abortion procedure. However, its positive effect on the safety or efficacy (ability to complete abortion) of the procedure has not been established. Our aim was to determine whether the use of pre-procedure US improves safety and/or efficacy of ...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2010.06.014

    authors: Kulier R,Kapp N

    更新日期:2011-01-01 00:00:00

  • Measuring decisional certainty among women seeking abortion.

    abstract:OBJECTIVE:Evaluating decisional certainty is an important component of medical care, including preabortion care. However, minimal research has examined how to measure certainty with reliability and validity among women seeking abortion. We examine whether the Decisional Conflict Scale (DCS), a measure widely used in ot...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.contraception.2016.09.008

    authors: Ralph LJ,Foster DG,Kimport K,Turok D,Roberts SCM

    更新日期:2017-03-01 00:00:00

  • Absorption of an oral contraceptive gestagen in ulcerative colitis before and after proctocolectomy and construction of a continent ileostomy.

    abstract::Plasma 1-norgestrel (1-Ng) levels after administration of a common oral contraceptive in fertile women (mean age 29 +/- 5 yrs) with mild ulcerative colitis before or after proctocolectomy with a conventional ileostomy or a continent ileostomy reservoir were determined and compared to those of a group of healthy volunt...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(85)90034-4

    authors: Nilsson LO,Victor A,Kral JG,Johansson ED,Kock NG

    更新日期:1985-02-01 00:00:00

  • Contraceptive efficacy of antimicrobial peptide Nisin: in vitro and in vivo studies.

    abstract::Sexually transmitted infections and unplanned pregnancies present a great risk to the reproductive health of women. Therefore, female-controlled vaginal products directed toward disease prevention and contraception are needed urgently. In the present study, efforts were made to evaluate the contraceptive potential of ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2003.11.002

    authors: Aranha C,Gupta S,Reddy KV

    更新日期:2004-04-01 00:00:00

  • Modified minilaparotomy technique of interval female sterilization.

    abstract::The study of a modified minilaparotomy technique of interval female sterilization is reported. The modified minilaparotomy technique of interval female sterilization is performed under local anesthesia using the Ramathibodi uterine manipulator, bivalve speculum, and a low midline incision. Sixty cases were treated wit...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(97)00043-7

    authors: Taneepanichskul S,Intaraprasert S,Chaturachinda K

    更新日期:1997-06-01 00:00:00

  • Fertility after discontinuation of contraception: a comprehensive review of the literature.

    abstract:BACKGROUND:Fear of adverse effects on subsequent fertility following reversible contraceptive use is an important concern for some women. STUDY DESIGN:We undertook a comprehensive and objective review of the literature for prospective studies reporting pregnancy rates in women following contraceptive cessation. One-ye...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2011.04.002

    authors: Mansour D,Gemzell-Danielsson K,Inki P,Jensen JT

    更新日期:2011-11-01 00:00:00

  • Users' perspectives on implantable contraceptives for women.

    abstract::Users of subdermal contraceptive implants report long duration of use, convenience, and high efficacy as liked features and bleeding irregularities, weight loss/gain, and headaches as disliked effects of these methods. Satisfied users tend to be women who do not experience side effects or women who value positive feat...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/s0010-7824(01)00281-5

    authors: Ortayli N

    更新日期:2002-01-01 00:00:00

  • Intraoperative placement of the Copper T-380 intrauterine devices in women undergoing elective cesarean delivery: a pilot study.

    abstract:BACKGROUND:The purpose of this pilot project was to test the feasibility of a technique designed to place a copper intrauterine device (IUD) through the hysterotomy incision of an elective cesarean delivery to minimize possible contamination and to guarantee that tailstrings were visible in the vagina for easy removal ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2009.01.014

    authors: Nelson AL,Chen S,Eden R

    更新日期:2009-07-01 00:00:00

  • Medical methods of early abortion in developing countries. Consensus statement. The Population Council.

    abstract::Researchers, health care providers, women's health advocates, donors, and representatives of ministries of health convened in Bellagio, Italy, in July 1998, to assess the potential of medical methods of early pregnancy termination to improve the reproductive health of women in developing countries. Consensus was reac...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(98)00109-7

    authors:

    更新日期:1998-11-01 00:00:00

  • Induction of menstruation by antiprogesterone ZK 98.299 in cycling bonnet monkeys.

    abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(87)90077-1

    authors: Puri CP,Elger WG,Pongubala JM

    更新日期:1987-04-01 00:00:00

  • Treatment of pain during medical abortion.

    abstract::A structured literature review was undertaken to determine, in the context of early medical abortion, the proportion of women who require analgesia, the predictors of analgesia requirement and the most appropriate analgesia regimen. Studies from different centers show wide variations in analgesia use, but, overall, ar...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2006.03.002

    authors: Penney G

    更新日期:2006-07-01 00:00:00

  • Measuring the effects of unintended pregnancy on women's quality of life.

    abstract:BACKGROUND:This study was conducted to assess the potential impact of an unintended pregnancy on women's quality of life. STUDY DESIGN:We asked 192 nonpregnant women to report how they would feel if they learned that they were pregnant using a visual analog scale (VAS), a time trade-off (TTO) metric, a standard gamble...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2008.04.120

    authors: Schwarz EB,Smith R,Steinauer J,Reeves MF,Caughey AB

    更新日期:2008-09-01 00:00:00

  • Contraceptive use among women with cystic fibrosis: A pilot study linking reproductive health questions to the Cystic Fibrosis Foundation National Patient Registry.

    abstract:OBJECTIVES:To examine contraceptive use, pregnancy intention and the association of hormonal contraceptive type with adverse health outcomes among women with cystic fibrosis (CF). STUDY DESIGN:We recruited 150 women with CF, ages 18-49 from three adult CF programs to complete an online survey regarding their pregnancy...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.02.006

    authors: Godfrey EM,Mody S,Schwartz MR,Heltshe SL,Taylor-Cousar JL,Jain R,Sufian S,Josephy T,Aitken ML

    更新日期:2020-06-01 00:00:00

  • Clinical utility of urine pregnancy assays to determine medical abortion outcome is limited.

    abstract:BACKGROUND:Determining medical abortion outcome commonly includes a costly evaluation such as ultrasonography or serial serum hCG testing. Urine pregnancy testing may represent a less costly alternative. METHODS:This prospective diagnostic test evaluation study was part of a multisite randomized trial of 1080 women un...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2007.01.021

    authors: Godfrey EM,Anderson A,Fielding SL,Meyn L,Creinin MD

    更新日期:2007-05-01 00:00:00