当前位置： SCI文献检索 > CONTRACEPTION期刊下所有文献 > Interleukin-6 and tumor necrosis factor-alpha concentrations in the intrauterine cavity of postmenopausal women using an intrauterine delivery system releasing progesterone. A possible mechanism of action of the intrauterine device.

Interleukin-6 and tumor necrosis factor-alpha concentrations in the intrauterine cavity of postmenopausal women using an intrauterine delivery system releasing progesterone. A possible mechanism of action of the intrauterine device.

Abstract：

:Intrauterine devices (IUD) provide effective contraception. The current study evaluates the concentration of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the intrauterine fluid of postmenopausal women using an intrauterine delivery system releasing progesterone (IDS-P). Intrauterine fluid was obtained by lavage, and IL-6 and TNF-alpha were analyzed using an enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed with a one-way analysis of variance (ANOVA). Intrauterine fluid IL-6 levels were 33.6 vs 6.09 pg/sample IDS-P vs no IDS-P (p = 0.0301). Intrauterine TNF-alpha levels for women using the IDS-P were higher than in nonusers, but the differences did not reach statistical significance. IL-6 and TNF-alpha levels were increased in the intrauterine cavity of postmenopausal women with an IDS-P. These data suggest that secreted cytokines could be a potential mechanism of IUD contraceptive efficacy. :This paper examines the possible mechanism of action of a progesterone-releasing IUD (P-IUD) by evaluating the concentration of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the intrauterine fluid of postmenopausal women using such a device. IL-6 and TNF-alpha were examined using an enzyme-linked immunosorbent assay (ELISA), while the intrauterine fluid was obtained by lavage. Intrauterine fluid IL-6 levels were 33.6 vs. 6.09 pg/sample for P-IUD vs. non-P-IUD users (p = 0.0301). Higher intrauterine TNF-alpha levels were observed in women using the P-IUD than in nonusers. The cells found in the intrauterine fluid of the P-IUD users were mostly histiocytes (macrophages) based on their morphologic characteristics. Increased IL-6 and TNF-alpha levels were found in the intrauterine cavity of postmenopausal women using a P-IUD. These results indicate that cytokines could play a significant role in the contraceptive mechanism of action of the IUD when used by premenopausal women.

journal_name

Contraception

journal_title

Contraception

authors

Archer DF,DeSoto KR,Baker JM

doi

10.1016/s0010-7824(99)00014-1

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

175-9

issue

3

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(99)00014-1

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验

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