Abstract：
:Since peritubular smooth muscle cells (PSMCs) have been characterized, isolated and cultured in homogeneous populations, the regulation of seminiferous epithelium contractility has received increasing attention. The present article reports and discusses experimental evidence demonstrating that: (1) PSMCs express two types of high affinity receptors for endothelin (ET-A and ET-B), both responsible for calcium-mediated cell contraction, but coupled to partially different transduction pathways; (2) the production of endothelin by seminiferous epithelium follows a finely regulated spatial and temporal pattern, which is based on the cyclic expression of endothelin-converting-enzyme in Sertoli cells; and (3) a further local factor, PDGF-BB, is capable of stimulating PSMC contraction when acutely administered and induces cell hypertrophy and potentiation of contractile phenotype when chronically administered, in the absence of any proliferative response. The study of the mechanisms through which PSMC contractile activity and differentiated state is locally controlled may be of potential relevance to our knowledge of how the efficiency of tubular output is regulated in normal and pathological conditions.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Palombi F,Filippini A,Chiarenza Cdoi
10.1016/s0010-7824(01)00319-5subject
Has Abstractpub_date
2002-04-01 00:00:00pages
289-91issue
4eissn
0010-7824issn
1879-0518pii
S0010782401003195journal_volume
65pub_type
杂志文章,评审相关文献
CONTRACEPTION文献大全abstract：OBJECTIVES:To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN:This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; r...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.04.007
更新日期：2018-04-18 00:00:00
abstract：OBJECTIVE:To estimate the effect of increased body weight and body mass index (BMI) on pregnancy rates with levonorgestrel (LNG) 1.5mg used as emergency contraception (EC). METHODS:The study reviewed data from 6873 women in four WHO-HRP randomized trials on EC conducted between 1993 and 2010. Participants took either ...
journal_title：Contraception
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.contraception.2016.08.001
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:We examined the association between quality of postpartum contraceptive counseling and changes in contraceptive method preference between delivery and 3-months postpartum. STUDY DESIGN:We used data from 1167 postpartum women delivering at eight hospitals in Texas who did not initiate contraception in the ho...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.08.011
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:It can prove challenging to create social marketing materials aimed at a specific subsection of the population, especially when the topic is relatively new and possibly misunderstood. Therefore, the objective of this study was to assess adolescent knowledge of and attitudes towards emergency contraception (E...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.08.005
更新日期：2010-02-01 00:00:00
abstract：:A long-term follow-up study compared development and health of 128 breast-fed children whose mothers had received depot-medroxyprogesterone acetate (depot-MPA) while lactating and 142 control children whose mothers had used mechanical contraceptives or no contraceptives or had undergone sterilization. The children, wh...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(84)90002-7
更新日期：1984-12-01 00:00:00
abstract：:A 10% sample of the data from East China from the two-per-thousand fertility and contraception survey of the Chinese State Family Planning Committee was analysed to study determinants of contraceptive choice in three situations: after first surviving delivery; before first abortion after first surviving delivery; and ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(93)90022-y
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVE:Our objective was to measure the sensitivity and specificity of a six-item "pregnancy checklist" at excluding early- or luteal-phase pregnancy among women with a negative urine pregnancy test who were initiating contraception. STUDY DESIGN:This was a secondary analysis of the Contraceptive CHOICE Project, a ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.08.002
更新日期：2015-01-01 00:00:00
abstract：:The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of spe...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(03)00076-3
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2016.06.012
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The FDA approval of mifepristone in 2000 broadened the available options for abortion. The aim of this study was to evaluate whether physicians in New Mexico have integrated the use of mifepristone into their practice. STUDY DESIGN:We performed a mail-out survey of New Mexico Obstetrician Gynecologists (Ob-...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.11.021
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:The gold standard for measuring oral contraceptive (OC) pharmacokinetics is the 24-h steady-state area under the curve (AUC). We conducted this study to assess whether limited sampling at steady state or measurements following use of one or two OCs could provide an adequate proxy in epidemiological studies fo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.12.007
更新日期：2017-04-01 00:00:00
abstract：:The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk of venous thromboembolism (VTE) in young women. A 5-year case-control study including all Danish hospitals was conducted. All women 15-44 years old, suffering a first ever deep venous thrombosis or a first pulmonary emboli...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(01)00307-9
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:While the intra-uterine device (IUD) is the second most popular contraceptive method in France, its use remains low among women most at risk of unintended pregnancies. Acknowledging the conjoint role of women and physicians in contraceptive decision making, we investigate the determinants of IUD use and IUD r...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.10.003
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To determine the acceptability of taking mifepristone at home for early medical abortion in the United States. STUDY DESIGN:This prospective, non-randomized, open-label study at six Planned Parenthood centers gave women with pregnancies up to 63 days' gestation seeking medical abortion the choice of taking m...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.contraception.2015.06.026
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:This study was conducted to assess the efficacy and incidence of side effects of a regimen of repeated doses of 400 microg sublingual misoprostol for termination of pregnancy of <7 weeks gestation. METHOD:Fifty women were given 400 microg sublingual misoprostol every 3 h for three doses. Two additional dose...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(03)00134-3
更新日期：2003-08-01 00:00:00
abstract：:This article presents results from a small, introductory clinical study offering a simplified regimen medical abortion to women in Turkey. A total of 208 women from five sites were recruited from July 2000 through March 2001. All eligible consenting women were given 200 mg oral mifepristone at the clinic followed by 4...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2004.05.005
更新日期：2004-11-01 00:00:00
abstract：:The efficacy and acceptability of a levonorgestrel-releasing intravaginal ring (IVR) for contraception was assessed in a British cohort studied as part of a multicentre, multinational clinical trial performed under the auspices of the World Health Organisation. One-hundred-and-fifty women took part in the study in two...
journal_title：Contraception
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0010-7824(91)90040-m
更新日期：1991-02-01 00:00:00
abstract：:Roussel Uclaf in partnership with the INSERM unit of Prof. E.E. Baulieu first discovered mifepristone (RU486) as part of a large research program on steroidal compounds with antihormone properties. Exhibiting a strong affinity to the progesterone and the glucocorticoid receptors, mifepristone exerted competitive antag...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(03)00171-9
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:Higher rates of unwanted pregnancies and lower rates of contraceptive use have been reported among Hispanic women than among non-Hispanic whites. Despite these differences, it is unclear how these groups differ with respect to various psychosocial factors that are associated with contraceptive decision makin...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2006.02.010
更新日期：2006-08-01 00:00:00
abstract：:The object of this study was to investigate the effects of combined oral contraceptives on pituitary-ovarian function during the menstrual cycle of lactating women whose prolactin levels were usually elevated. Five of six lactating women studied were considered to have the normal menstrual cycle which was comparable t...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90008-2
更新日期：1983-03-01 00:00:00
abstract：:The rheological properties of four commercially available spermicidal gels (two polyacrylic acid derivatives and two carboxymethylcellulose based) and their dilutions with a vaginal fluid simulant (pH 4.2) and a semen simulant (pH 7.7) were measured at 25 degrees C and 37 degrees C over a biologically relevant range o...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00430-4
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:With the rising influx of Hispanics to the United States, there is an ongoing need to promote health and wellness care to this non-English-speaking, minority population group. Programs, specifically developed to address the unique cultural mores of Hispanics, need to focus on increasing knowledge about healt...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2007.12.008
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:Women who have abortions are at high risk of contraception discontinuation and subsequent unintended pregnancy. The objective of this analysis was to identify factors associated with choice of highly effective, long-acting, progestin-only contraceptive methods after abortion. STUDY DESIGN:Women presenting fo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.06.013
更新日期：2015-12-01 00:00:00
abstract：:Data from published studies of the quantity of medroxyprogesterone acetate and/or its metabolites in the milk of lactating women receiving Depo-Provera for contraception is extrapolated into the amount of drug ingested daily by a theoretically average infant. Comparisons are made with the results of similar studies in...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(81)90027-5
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:The study was conducted to determine the impact of switching from oral to transdermal patch or vaginal ring contraception on biomarkers of thrombosis. STUDY DESIGN:Current healthy oral contraceptive (OC) users were randomized to switch to either a contraceptive ring (CR) or patch (CP) and underwent phleboto...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2008.07.004
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Ethinyl estradiol (EE) and progestins have the ability to alter endothelial function. The type of progestin and the ratio of EE to progestin used in oral contraceptive pills (OCPs) may determine how they affect the arterial vasculature. STUDY DESIGN:In this study, we investigated endothelial function across...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2008.07.025
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact of a scholarly concentration for medical students, which aims to develop students' research, clinical and advocacy skills to promote women's reproductive health. STUDY DESIGN:Scholarly concentration programs provide opportunities to engage in scholarship beyond the traditional medical...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2014.07.005
更新日期：2014-11-01 00:00:00
abstract：:To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(72)90011-x
更新日期：1972-06-01 00:00:00
abstract：:The study of a modified minilaparotomy technique of interval female sterilization is reported. The modified minilaparotomy technique of interval female sterilization is performed under local anesthesia using the Ramathibodi uterine manipulator, bivalve speculum, and a low midline incision. Sixty cases were treated wit...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(97)00043-7
更新日期：1997-06-01 00:00:00
abstract：:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(89)80004-6
更新日期：1989-02-01 00:00:00
