Delayed implantation induced by fadrozole hydrochloride in rats.

Abstract:

:The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of sperm detection) through Day 7 of pregnancy using a mini-osmotic pump was found to delay the initiation of implantation by 1 or 2 days with no negative effects on embryonic viability. The Fad treatment delayed preimplantation embryo development and zona shedding by embryos. The treatment also delayed the period of maximum sensitivity to a decidualizing stimulus (intraluminal infusion of sesame oil) by 2 days. The results show that continuous treatment with Fad has multiple anti-implantation effects in rats.

journal_name

Contraception

journal_title

Contraception

authors

Tamada H,Mizuta Y,Kawate N,Inaba T,Sawada T

doi

10.1016/s0010-7824(03)00076-3

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

65-8

issue

1

eissn

0010-7824

issn

1879-0518

pii

S0010782403000763

journal_volume

68

pub_type

杂志文章
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    journal_title:Contraception

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    authors: Sivin I

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    authors: Heinemann K,Reed S,Moehner S,Minh TD

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    authors: Sivin I,Diaz J,Alvarez F,Brache V,Diaz S,Pavez M,Stern J

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  • Plasma levels and progestational activity of levonorgestrel after repeated intravenous and subcutaneous administration in the beagle bitch.

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(84)90068-4

    authors: Düsterberg B,Beier S

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  • Copper levels in maternal and fetal tissues of rabbits bearing intrauterine copper wires.

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    journal_title:Contraception

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    doi:10.1016/0010-7824(74)90060-2

    authors: Moo-Young AJ,Tatum HJ

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  • The influence of hormonal contraceptives on sex hormone binding globulin (SHBG) capacity.

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    doi:10.1016/0010-7824(92)90094-a

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    pub_type: 杂志文章,随机对照试验

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  • Subcutaneous DMPA vs. intramuscular DMPA: a 2-year randomized study of contraceptive efficacy and bone mineral density.

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    pub_type: 杂志文章,多中心研究,随机对照试验

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