Abstract:
:The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of sperm detection) through Day 7 of pregnancy using a mini-osmotic pump was found to delay the initiation of implantation by 1 or 2 days with no negative effects on embryonic viability. The Fad treatment delayed preimplantation embryo development and zona shedding by embryos. The treatment also delayed the period of maximum sensitivity to a decidualizing stimulus (intraluminal infusion of sesame oil) by 2 days. The results show that continuous treatment with Fad has multiple anti-implantation effects in rats.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Tamada H,Mizuta Y,Kawate N,Inaba T,Sawada Tdoi
10.1016/s0010-7824(03)00076-3subject
Has Abstractpub_date
2003-07-01 00:00:00pages
65-8issue
1eissn
0010-7824issn
1879-0518pii
S0010782403000763journal_volume
68pub_type
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