Bleeding patterns with monophasic and triphasic low-dose ethinyl estradiol combined oral contraceptives.

Abstract:

BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of norgestimate (NGM) 180/215/250 mcg/ethinyl estradiol (EE) 25 mcg (n=1506) and norethindrone acetate 1 mg/EE 20 mcg (n=1057). In this retrospective analysis, the incidence of breakthrough bleeding/spotting (BTB/S) was evaluated in women stratified by age (18-24, 25-34 and >34 years) and weight (155 lb). RESULTS:A lower percentage of women experienced BTB/S with NGM/EE during most cycles, regardless of age or weight, compared with norethindrone acetate/EE. At Cycle 6, the incidences of BTB/S for NGM/EE versus norethindrone acetate/EE were as follows: 18-24 years, 10.9% versus 29.7% (p<.0001); 25-34 years, 10.9% versus 18.6% (p<.001); >34 years, 8.1% versus 19.1% (p<.005); 155 lb, 10.0% versus 18.3% (p<.01). CONCLUSION:NGM/EE provided better cycle control as defined by BTB/S compared with norethindrone acetate/EE, regardless of subject age or weight for six cycles.

journal_name

Contraception

journal_title

Contraception

authors

Hampton RM,Zhang HF,Barnowski C,Wan GJ

doi

10.1016/j.contraception.2008.02.007

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

415-9

issue

6

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(08)00092-9

journal_volume

77

pub_type

杂志文章,多中心研究,随机对照试验
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  • Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat.

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    abstract::The efficacy and acceptability of a levonorgestrel-releasing intravaginal ring (IVR) for contraception was assessed in a British cohort studied as part of a multicentre, multinational clinical trial performed under the auspices of the World Health Organisation. One-hundred-and-fifty women took part in the study in two...

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    doi:10.1016/0010-7824(91)90040-m

    authors: Elder MG,Lawson JP,Elstein M,Nuttall ID

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    pub_type: 杂志文章

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    authors: Fjerstad M,Trussell J,Lichtenberg ES,Sivin I,Cullins V

    更新日期:2011-04-01 00:00:00

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

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    authors: Chi IC,Farr G,Dominik R,Robinson N

    更新日期:1990-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90088-8

    authors: Schwallie PC,Huang DC,Turner LF

    更新日期:1980-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90074-7

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.09.006

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    更新日期:1985-05-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(95)00149-5

    authors: Mahmud M,Islam MM

    更新日期:1995-09-01 00:00:00

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Juan QL,Zhi LJ,Juan SL,Yi WM,Wu GM

    更新日期:1990-10-01 00:00:00

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    pub_type: 杂志文章

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    authors: Rosenzweig BA,Even A,Budnick LE

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(86)90096-x

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    更新日期:1986-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(86)90047-8

    authors: Hasenack HG,Bosch AM,Käär K

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  • Is pregnancy fatalism normal? An attitudinal assessment among women trying to get pregnant and those not using contraception.

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.05.015

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    更新日期:2018-10-01 00:00:00

  • Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment.

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    更新日期:1997-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/s0010-7824(98)00109-7

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    pub_type: 杂志文章,评审

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    更新日期:2006-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.12.005

    authors: Kayikcioglu F,Gunes M,Ozdegirmenci O,Haberal A

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    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2016.06.014

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    pub_type: 杂志文章

    doi:10.1016/s0010-7824(09)91004-6

    authors: Stube R,Voeller B,Davidhazy A

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    doi:10.1016/j.contraception.2012.08.040

    authors: Nagy GR,Győrffy B,Nagy B,Rigó J Jr

    更新日期:2013-04-01 00:00:00