Abstract：
:In a cross-over study with orally administered desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) and 3-keto-desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) in ten women under steady-state conditions, the serum levels of 3-keto-desogestrel were monitored by radioimmunoassay. No statistically significant differences between treatment groups were found with respect to the areas under the curve of the serum levels versus time (AUC), peak heights and peak times. The individual AUCs for 3-keto-desogestrel after dosing with desogestrel (plus EE) or 3-keto-desogestrel (plus EE) show a similar degree of variation. The biotransformation of desogestrel into 3-keto-desogestrel is rapid and appears not to be limited by the metabolic capacity of the normal liver.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Hasenack HG,Bosch AM,Käär Kdoi
10.1016/0010-7824(86)90047-8subject
Has Abstractpub_date
1986-06-01 00:00:00pages
591-6issue
6eissn
0010-7824issn
1879-0518pii
0010-7824(86)90047-8journal_volume
33pub_type
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