Abstract：
PURPOSE:This prospective study aimed to assess the possible effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and fasting blood glucose levels over a period of 1 year. METHODS:Forty-eight premenopausal women, attending our gynecology clinic with the complaint of menorrhagia, were enrolled in the study. Systolic and diastolic blood pressures were recorded. Serum concentrations of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and fasting plasma glucose (FPG) levels were tested before (pretreatment group) and 1 year later following insertion (on-treatment group). Baseline mean parameters were compared with mean parameters at 1 year for statistical significance using paired samples t-test. RESULTS:Thirty-three (68.75%) women were eligible for control in the on-treatment group. Mean age of the patients was 44.34+/-7.59 years. The study results showed that mean FPG level was significantly increased, whereas mean diastolic blood pressure was significantly decreased. Although mean systolic blood pressure tended to decrease and HDL-C concentrations to increase, these changes from baseline levels were insignificant. There were no significant changes in mean TG, TC, VLDL, LDL, AST and ALT. DISCUSSION:The only significant unfavorable effect observed was an increase in FPG level. Since it did not rise to risky values, but alerted us for the high risk patients for glucose intolerance before insertion. The LNG-IUS can be regarded as being safe in their effects on lipid metabolism, blood pressure and liver function tests.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Kayikcioglu F,Gunes M,Ozdegirmenci O,Haberal Adoi
10.1016/j.contraception.2005.12.005subject
Has Abstractpub_date
2006-05-01 00:00:00pages
528-31issue
5eissn
0010-7824issn
1879-0518pii
S0010-7824(05)00485-3journal_volume
73pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：BACKGROUND:The Affordable Care Act (ACA) will expand health care coverage to low-income Americans. Contraception services are a mandated component of ACA plans. STUDY DESIGN:A decision-analytic model was developed to compare the costs and outcomes of the current versus the proposed plan for contraceptive coverage (Fed...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2012.06.009
更新日期：2013-02-01 00:00:00
abstract：:Ovarian function, bleeding patterns and serum lipoproteins were studied in women using contraceptive vaginal rings (CVRs) of dimethyl-polysiloxane impregnated with steroids. The different CVRs were used for about 10 cycles each. The following groups were studied, with the daily steroid dosage given in parentheses. Wom...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90033-1
更新日期：1983-10-01 00:00:00
abstract：BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volun...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2007.08.006
更新日期：2007-12-01 00:00:00
abstract：:A report that serum prolactin concentrations were almost doubled by the use of copper IUDs led us to study the effect of both copper and inert IUDs. We studied 105 normal women in whom all other prolactinergic factors had been excluded; 25 of them were using copper IUDs, 25 were using inert IUDs and there were 55 cont...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(79)90049-0
更新日期：1979-11-01 00:00:00
abstract：BACKGROUND:Lactic acid production is considered to be the major protection mechanism of lactobacilli against vaginal infections due to genital pathogens. Some species of Lactobacillus are also hydrogen peroxide (H(2)O(2)) producers. Nonoxynol-9 (N-9) is a nonionic detergent and is the active component of many spermicid...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2005.06.066
更新日期：2006-01-01 00:00:00
abstract：:In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin), with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (EE + DSG = Marvelon) on the lipid profile. The prim...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.contraception.2003.11.003
更新日期：2004-04-01 00:00:00
abstract：:Experiments were conducted to determine whether oral administration of a water extract of P. dodecandra had significant effects on reproduction in mice. The work is based on earlier reports in this journal that butanol extracts of the berries of this plant had spermatocidal properties in vitro and blastocidal activity...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(87)80006-9
更新日期：1987-02-01 00:00:00
abstract：OBJECTIVE:Determine if erythromycin is an effective agent for achieving occlusion of the Fallopian tube for nonsurgical female sterilization. METHODS:Two studies of 100 healthy volunteers requesting sterilization were planned, one in Julpia Andhermanik and the other in Kolkata (Calcutta). A readily available marketed ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2003.07.005
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:To increase access to safe abortion in rural India, the feasibility and acceptability of mifepristone-misoprostol abortion was assessed in a typical government run primary health center (PHC) in Nagpur district, Maharashtra State, that does not offer surgical abortion services and must refer off-site for e...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2007.03.010
更新日期：2007-07-01 00:00:00
abstract：:In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(80)80001-1
更新日期：1980-09-01 00:00:00
abstract：:Data from published studies of the quantity of medroxyprogesterone acetate and/or its metabolites in the milk of lactating women receiving Depo-Provera for contraception is extrapolated into the amount of drug ingested daily by a theoretically average infant. Comparisons are made with the results of similar studies in...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(81)90027-5
更新日期：1981-04-01 00:00:00
abstract：:The objective of this study was to describe the availability of early surgical and medical abortion among members of the National Abortion Federation (NAF) and to identify factors affecting the integration of early abortion services into current services. Telephone interviews were conducted with staff at 113 Planned P...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00512-7
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:This study aims to compare the cost-effectiveness of oral contraceptives (OCs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and surgical management in treating dysfunctional uterine bleeding (DUB) in women not desiring additional children. METHOD:A Markov model was constructed from the perspec...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2006.03.024
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:To assess patterns of contraceptive use at last intercourse among women with physical or cognitive disabilities compared to women without disabilities. STUDY DESIGN:We analyzed responses to 12 reproductive health questions added by seven states to their 2013 Behavioral Risk Factor Surveillance System questio...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2017.12.008
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Little is known about the out-of-pocket expenditures and dispensing patterns for oral contraceptive pills (OCPs), factors associated with these outcomes and whether they change over time. STUDY DESIGN:Observational cohort using 1996-2006 Medical Expenditure Panel Surveys. RESULTS:Women spent $16 out-of-poc...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.09.013
更新日期：2011-06-01 00:00:00
abstract：:The potent luteinizing hormone-releasing hormone (LRH) agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 or 25 microgram for 1, 3 or 5 consecutive days to twelve regularly menstruating women in the early follicular phase of the menstrual cycle in an attempt to disturb follicular maturatio...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(82)90016-6
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:Barriers to intrauterine device (IUD) use in nulliparous women include fear of pain with insertion and provider perception of difficulty with insertion. The goal of this study was to evaluate whether misoprostol prior to IUD insertion in nulliparous women eased insertion and decreased pain. STUDY DESIGN:Thi...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2013.07.011
更新日期：2013-12-01 00:00:00
abstract：:This randomized, double-blind, placebo-controlled exploratory study examined the efficacy and safety of a low-dose oral contraceptive (Mircette), desogestrel/ethinyl estradiol [DSG/EE] and ethinyl estradiol [EE]) in relieving the symptoms of dysmenorrhea. Twenty-three clinics in the United States enrolled 77 women (ag...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(02)00414-6
更新日期：2002-12-01 00:00:00
abstract：:The ability of the condom wall to maintain its integrity throughout sexual intercourse is critical to its role in halting the spread of major sexually transmissible pathogens including the human immunodeficiency virus. There are three principal in vitro performance tests applied to condoms: a test for freedom from hol...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(91)90045-h
更新日期：1991-02-01 00:00:00
abstract：:The objective of the study was to assess the efficacy of cervical preparation with misoprostol or laminaria suction abortion up to 18 weeks gestation. The study was conducted among a consecutive case series of patients presenting for dilatation and evacuation at a single center. Cervical preparation was effected by ei...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00306-2
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:The FDA approval of mifepristone in 2000 broadened the available options for abortion. The aim of this study was to evaluate whether physicians in New Mexico have integrated the use of mifepristone into their practice. STUDY DESIGN:We performed a mail-out survey of New Mexico Obstetrician Gynecologists (Ob-...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.11.021
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2016.06.012
更新日期：2016-12-01 00:00:00
abstract：:The metabolic and hemostatic effects of two oral contraceptives containing 150 mcg desogestrel and 20 mcg ethinyl-estradiol (EE) (MERCILON) or 30 mcg EE (MARVELON) were compared in order to examine the effect of reducing the EE dose in contraceptive pills. Forty-nine women participated in this randomized study during ...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(93)90141-s
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether conducting a bimanual examination prior to medication abortion (MAB) provision results in meaningful changes in gestational age (GA) assessment after patient-reported last menstrual period (LMP) in Nepal. STUDY DESIGN:Women ages 16-45 (n=660) seeking MAB at twelve participating pharmacies...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.06.004
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:To evaluate the impact on lipid and carbohydrate variables of a combined one-third ethinyl estradiol (EE)/levonorgestrel (LNG) dose reduction in oral contraceptives. METHODS:In an open-label, randomized study, a dose-reduced oral contraceptive containing 20 microg EE and 100 microg LNG (20 EE/100 LNG) was c...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.contraception.2004.08.017
更新日期：2005-02-01 00:00:00
abstract：:A variety of epidemiological approaches have been used to assess the safety of steroid contraceptives. Each study design has its own strengths and weaknesses, especially with respect to susceptibility to bias and confounding. Randomized controlled trials provide the strongest evidence of a cause and effect relationshi...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/s0010-7824(98)00013-4
更新日期：1998-03-01 00:00:00
abstract：:On September 23, 2016, California became the sixth state to pass legislation requiring health plans and insurers to cover a 12-month supply of FDA-approved self-administered hormonal contraceptives such as contraceptive pills, patches and vaginal rings. This legislation is estimated to result in 38% of current contrac...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.12.008
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Surgical sterilization has many advantages. Previous information on prevalence and correlates was based on surveys of women. STUDY DESIGN:We estimated the prevalence of vasectomy and tubal ligation of partners for male participants in the 2002 National Survey of Family Growth, a nationally representative su...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.03.018
更新日期：2010-09-01 00:00:00
abstract：:Medically induced abortion using a new regimen of oral mifepristone 600 mg and vaginal misoprostol 800 micrograms (PGE1 analogue) was carried out in 100 women. Abortion occurred in all patients without resort to surgery. In 99 women, the abortion occurred within 4 hours of the administration of the prostaglandin. Sixt...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(94)90085-x
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Given the need for a 90-day post-Essure hysterosalpingogram (HSG) to confirm proper tubal placement and occlusion, we examined the impact of dedicating a staff nurse to schedule HSG appointments, call with appointment reminders and track HSG compliance for patients who had Essure. STUDY DESIGN:We performed ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2010.01.019
更新日期：2010-06-01 00:00:00
