Abstract：
:Eight investigators, using a common protocol, studied the use of intramuscular (15S)-15-methyl prostaglandin F2 alpha to abort midtrimester pregnancies which had failed treatment by other methods in 398 cases. Results of treatment of 3 subgroups, defined by reason for primary treatment failure, are presented. The combined efficacy rate was 96.2% with 79.6% of the abortions being complete. The mean time from starting intramuscular therapy to successful abortion was 7.35 hours. The incidence of gastrointestinal side-effects was lower than that previously reported for systemically administered prostaglandins. Serious complications were not appreciably different from those reported for commonly used methods of second trimester abortion except for a slightly higher incidence of excessive bleeding requiring blood replacement. Advantages of this method over currently used methods of treating failures of primary attempts to induce midtrimester abortion by pharmacologic means are discussed. :Intramuscular injections of 250-500 mg. of prostaglandin F2 alpha were administered to 398 women to induce midtrimester abortion after other methods had failed. There was an overall efficiency rate of 96.2% with 79.6% complete abortions in a mean time of 7.35 hours. Adverse reactions were primarily vomting, diarrhea, nausea, and temperature elevation. The incidence of such side effects was high, but severity was mild and well tolerated. Incidence of serious complications was not higher than that associated with other abortion methods, except for the incidence of excessive hemorrhage and blood replacement. In general, results of this study were similar to those reported in previous publications.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Schwallie PC,Huang DC,Turner LFdoi
10.1016/0010-7824(80)90088-8subject
Has Abstractpub_date
1980-12-01 00:00:00pages
623-42issue
6eissn
0010-7824issn
1879-0518pii
0010-7824(80)90088-8journal_volume
22pub_type
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