Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat.

Abstract:

PURPOSE:Quantitative evaluation of properties of bromhexine (B) for expression of uterine proteins in ovariectomized (OVX) and pregnant rats. MATERIALS AND METHODS:Expression of proteins through SDS-PAGE, along with incorporation of glycosidic moieties, was conducted in pregnant and OVX rats under B influence. These findings were corroborated with other tests such as implantation sites, fetal and litter sizes in pregnant rats. RESULTS:In OVX animals, even under the influence of estradiol dipropionate and progesterone, the B recreated a condition akin to OVX animals. It also induced 50-80% inhibition in the incorporation of glycosidic moieties to polypeptide chain. Distinct reduction in implantation sites, fetal sizes and interference in the conception (16/46) in pregnant rats substantiated the results of the action of B as an antiimplantation agent. CONCLUSION:Bromhexine has shown interference in blastocyst attachment, conception, reduction in number of implantation sites and dwarfing of fetuses; hence, it is a potential candidate for antiimplantation.

journal_name

Contraception

journal_title

Contraception

authors

Singh N,Malaviya B

doi

10.1016/j.contraception.2005.11.006

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

645-53

issue

6

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(05)00484-1

journal_volume

73

pub_type

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