Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat.


PURPOSE:Quantitative evaluation of properties of bromhexine (B) for expression of uterine proteins in ovariectomized (OVX) and pregnant rats. MATERIALS AND METHODS:Expression of proteins through SDS-PAGE, along with incorporation of glycosidic moieties, was conducted in pregnant and OVX rats under B influence. These findings were corroborated with other tests such as implantation sites, fetal and litter sizes in pregnant rats. RESULTS:In OVX animals, even under the influence of estradiol dipropionate and progesterone, the B recreated a condition akin to OVX animals. It also induced 50-80% inhibition in the incorporation of glycosidic moieties to polypeptide chain. Distinct reduction in implantation sites, fetal sizes and interference in the conception (16/46) in pregnant rats substantiated the results of the action of B as an antiimplantation agent. CONCLUSION:Bromhexine has shown interference in blastocyst attachment, conception, reduction in number of implantation sites and dwarfing of fetuses; hence, it is a potential candidate for antiimplantation.






Singh N,Malaviya B




Has Abstract


2006-06-01 00:00:00














  • Contraceptive failure in the United States.

    abstract::This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...


    pub_type: 杂志文章,评审


    authors: Trussell J

    更新日期:2011-05-01 00:00:00

  • Pregnancy intentions and contraceptive uptake after miscarriage.

    abstract:OBJECTIVE:To identify factors associated with contraceptive uptake among participants in a miscarriage management clinical trial. STUDY DESIGN:We performed a secondary analysis of a multi-center, randomized controlled trial of medical management regimens for miscarriage between 5 and 12 completed weeks. Pregnancy inte...


    pub_type: 杂志文章


    authors: Roe AH,McAllister A,Sammel MD,Schreiber CA

    更新日期:2020-06-01 00:00:00

  • Rebound of medication abortion in Texas following updated mifepristone label.

    abstract:BACKGROUND:In 2013, Texas House Bill 2 (HB 2) placed restrictions on the use of medication abortion, which later were nullified with the 2016 FDA-approved mifepristone label. METHODS:Using data collected directly from Texas abortion facilities, we evaluated changes in the provision and use of medication abortion durin...


    pub_type: 杂志文章


    authors: Baum SE,White K,Hopkins K,Potter JE,Grossman D

    更新日期:2019-05-01 00:00:00

  • Evaluation of the effect of a patient decision aid about vasectomy on the decision-making process: a randomized trial.

    abstract:BACKGROUND:Between 7% and 10% of men who choose vasectomy as a contraceptive method regret their decision. This study evaluates the effect of a patient decision aid (PtDA) designed to help men decide whether or not to have a vasectomy. STUDY DESIGN:Men considering vasectomy were randomized to an experimental group tha...


    pub_type: 杂志文章,随机对照试验


    authors: Labrecque M,Paunescu C,Plesu I,Stacey D,Légaré F

    更新日期:2010-12-01 00:00:00

  • Effects of levonorgestrel-releasing intrauterine system on glucose and lipid metabolism: a 1-year follow-up study.

    abstract:PURPOSE:This prospective study aimed to assess the possible effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and fasting blood glucose levels over a period of 1 year. METHODS:Forty-eight premenopausal women, attending our gynecology clinic with the complaint of menorrhagia, were en...


    pub_type: 杂志文章


    authors: Kayikcioglu F,Gunes M,Ozdegirmenci O,Haberal A

    更新日期:2006-05-01 00:00:00

  • Progestin-only pill use and pill switching during breastfeeding.

    abstract::The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...


    pub_type: 社论


    authors: Visness CM,Rivera R

    更新日期:1995-05-01 00:00:00

  • Weight change and adverse event incidence with a low-dose oral contraceptive: two randomized, placebo-controlled trials.

    abstract::Changes in body weight and the incidence of estrogen-related side effects with low-dose oral contraceptives (OCs) containing 20 microg ethinyl estradiol (EE) have not been demonstrated in placebo-controlled trials. Two placebo-controlled, randomized trials demonstrated the efficacy of a low-dose OC for the treatment o...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Coney P,Washenik K,Langley RG,DiGiovanna JJ,Harrison DD

    更新日期:2001-06-01 00:00:00

  • Effects of quinestrol on hepatic function in the rat.

    abstract::Hepatic function in female rats given 200 microgram of quinestrol every 15 days for up to 210 days was studied. Prolonged treatment with quinestrol affected liver weight, serum cholestrol levels, biliar flux, and bromosulphthalein test, but these parameters tended toward control levels after 30 days of treatment. Quin...


    pub_type: 杂志文章


    authors: Gioia IA,Lencioni LJ,Koch OR

    更新日期:1978-09-01 00:00:00

  • Clinical performance of the TCu 380A and Lippes Loop IUDs in three developing countries.

    abstract::The clinical performance of the Copper T 380A (TCu 380A) and the Lippes Loop intrauterine devices (IUDs) were evaluated for 12 months in a group of 710 women who had one of the two IUDs inserted. Results are from a randomized clinical trial conducted at three collaborating research sites located in three developing co...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Farr G,Amatya R,Acosta M,Ekwempu C,Kisninci H

    更新日期:1995-07-01 00:00:00

  • A comparative study of Neo Sampoon, Ortho Vaginal Tablets and Emko Vaginal Tablets in Accra, Ghana.

    abstract::Neo Sampoon is an effervescent contraceptive vaginal tablet manufactured in Japan that contains 60 mg of the spermicide menfegol. Ortho Vaginal Tablets (OVT) and Emko Vaginal Tablets (EVT), both containing 100 mg of the spermicide nonoxynol-9, were manufactured in the USA. The three products were compared in a randomi...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lamptey P,Klufio C,Smith SC,Feldblum PJ

    更新日期:1985-11-01 00:00:00

  • Inhibition of luteal phase progesterone levels in the rhesus monkey by epostane.

    abstract::This study examined the effect of epostane, a new antifertility drug, on normal and hCG-stimulated progesterone production during the luteal phase of the menstrual cycle in rhesus monkeys. When administered once each day for five days, epostane inhibited normal luteal phase progesterone levels in a dose-related fashio...


    pub_type: 杂志文章


    authors: Snyder BW,Schane HP

    更新日期:1985-05-01 00:00:00

  • Pharmacokinetic study of RU 486 and its metabolites after oral administration of single doses to pregnant and non-pregnant women.

    abstract::RU 486 and three of its metabolites (RU 42633-monodemethyl, RU 42848-didemethyl, and RU 42698-hydroxymetabolite) were determined by HPLC in plasma from nine non-pregnant and 36 pregnant women. Each non-pregnant subject took an oral dose of RU 486 (25, 100, 400 and 600 mg consecutively) once per menstrual cycle. Six of...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Shi YE,Ye ZH,He CH,Zhang GQ,Xu JQ,Van Look PF,Fotherby K

    更新日期:1993-08-01 00:00:00

  • Comparison of remote and in-clinic follow-up after methotrexate/misoprostol abortion.

    abstract:OBJECTIVE:This study compared adherence to follow-up and clinical outcomes between standard in-clinic and remote follow-up after methotrexate/misoprostol abortion. STUDY DESIGN:This nonrandomized trial recruited women requesting medical abortion at two sexual health clinics in Toronto, Canada. Women received methotrex...


    pub_type: 临床试验,杂志文章


    authors: Dunn S,Panjwani D,Gupta M,Meaney C,Morgan R,Feuerstein E

    更新日期:2015-09-01 00:00:00

  • Intrauterine contraception with copper and with levonorgestrel: a randomized study of the TCu 380Ag and levonorgestrel 20 mcg/day devices.

    abstract::First year results of a randomized study of 1509 users of the Copper T380Ag with a silver core or of an IUD releasing 20 mcg day of levonorgestrel are reported. The cumulative gross pregnancy rate for each device was 0.3 per 100 at one year, with more than 490 women having one year of use with each device. The levonor...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sivin I,Alvarez F,Diaz J,Diaz S,el Mahgoub S,Coutinho E,Brache V,Diaz MM,Faundes A,Pavez M

    更新日期:1984-11-01 00:00:00

  • A 4-year follow-up study of women with Norplant-2 contraceptive implants.

    abstract::One-hundred-thirty of 178 women who received Norplant-2 implants were followed prospectively for 4 years. Menstrual disorders were the most common reason for discontinuation. Only one patient conceived, for a failure rate of 0.6%. ...


    pub_type: 杂志文章


    authors: Qin LH,Goldberg JM,Hao G

    更新日期:2001-11-01 00:00:00

  • Early follicular phase luteinizing hormone-releasing hormone agonist administration - effects on follicular maturation and corpus luteum function in women.

    abstract::The potent luteinizing hormone-releasing hormone (LRH) agonist D-Ser(TBU)6-EA10-LRH was administered in a daily subcutaneous dose of 5 or 25 microgram for 1, 3 or 5 consecutive days to twelve regularly menstruating women in the early follicular phase of the menstrual cycle in an attempt to disturb follicular maturatio...


    pub_type: 杂志文章


    authors: Skarin G,Nillius SJ,Wide L

    更新日期:1982-01-01 00:00:00

  • Evaluation of contraceptive activity of a mineralo-herbal preparation in Sprague-Dawley rats.

    abstract:OBJECTIVE:This study was aimed to evaluate a marketed mineralo-herbal preparation containing plants known to have potent contraceptive activity, or contraindicated for use during pregnancy in folklore/ancient Indian literature and recommended for use as an appetizer and headache, hyperacidity and chronic constipation r...


    pub_type: 杂志文章


    authors: Srivastava SR,Kesarwani S,Keshri G,Singh MM

    更新日期:2005-12-01 00:00:00

  • Effect of a combined estrogen and progesterone oral contraceptive on circulating adipocytokines adiponectin, resistin and DLK-1 in normal and obese female rhesus monkeys.

    abstract:BACKGROUND:Hormonal contraception is the most common medication used by reproductive aged women but there is little understanding of the impact of hormonal contraception on obesity and metabolism. Adipokine levels (adiponectin, resistin) and markers of adipocyte development (DLK-1) are altered in obese animals and huma...


    pub_type: 杂志文章


    authors: Shaw KA,Hennebold JD,Edelman AB

    更新日期:2013-07-01 00:00:00

  • Access to single-visit IUD insertion at obstetrician-gynecology practices in Ohio: An audit study.

    abstract:OBJECTIVE:Single-visit intrauterine device (IUD) insertion protocols are recommended. We assessed the availability of single-visit IUD insertions, and whether access to these services varies by age, race or parity. STUDY DESIGN:Using audit study methodology, we called a random sample of 396 obstetrician-gynecology pra...


    pub_type: 杂志文章


    authors: Serpico JJ,Ricks JM,Smooth WG,Romanos C,Brook DL,Gallo MF

    更新日期:2020-09-01 00:00:00

  • ORTHO birth control satisfaction assessment tool: assessing sensitivity to change and predictors of satisfaction.

    abstract:OBJECTIVE:To test the sensitivity to change of the ORTHO Birth Control Satisfaction Assessment Tool (ORTHO BC-SAT) among dissatisfied women switching to a new hormonal birth control method and to better understand which factors contribute to a woman's satisfaction with the method. MATERIALS AND METHODS:Women switching...


    pub_type: 杂志文章,多中心研究


    authors: Mathias SD,Colwell HH,Lococo JM,Karvois DL,Pritchard ML,Friedman AJ

    更新日期:2006-10-01 00:00:00

  • Interaction of condom design and user techniques and condom acceptability.

    abstract::In 1991, the source of public sector condom supplies in an African country changed from USAID to WHO. Following a complaint, the two types of condoms were sampled and compared. Laboratory tests indicated that the new-style condoms were of adequate quality, but a number of differences were noted between the two types. ...


    pub_type: 杂志文章,评审


    authors: Gerofi J,Deniaud F,Friel P

    更新日期:1995-10-01 00:00:00

  • Levonorgestrel plasma concentrations and hormone profiles after insertion and after one year of treatment with a levonorgestrel-IUD.

    abstract::Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...


    pub_type: 杂志文章


    authors: Nilsson CG,Lähteenmäki P,Luukkainen T

    更新日期:1980-03-01 00:00:00

  • Abortion referral patterns among generalist OB/GYNs and primary care practitioners: A qualitative study.

    abstract:OBJECTIVE:An informed, timely referral from a generalist practitioner has the potential to facilitate care for a patient seeking an abortion. However it is unclear what barriers, if any, generalist practitioners perceive in this process. The objective of this study was to qualitatively characterize abortion referral pa...


    pub_type: 杂志文章


    authors: Linton A,Mendez SR,Simon MA

    更新日期:2020-02-01 00:00:00

  • The effect of levonorgestrel-releasing intrauterine device on menorrhagia in women taking anticoagulant medication after cardiac valve replacement.

    abstract:BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...


    pub_type: 杂志文章,随机对照试验


    authors: Kilic S,Yuksel B,Doganay M,Bardakci H,Akinsu F,Uzunlar O,Mollamahutoglu L

    更新日期:2009-08-01 00:00:00

  • Progestin-only pill use over 6 months postpartum.

    abstract:OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...


    pub_type: 杂志文章


    authors: Uhm S,Garcia-Ruiz N,Creinin MD,Blanton A,Chen MJ

    更新日期:2020-10-01 00:00:00

  • Endometrial estradiol-17 beta-dehydrogenase activity in women wearing Cu-IUD.

    abstract::In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this de...


    pub_type: 杂志文章


    authors: Tseng L,Dramusic V,Gurpide E

    更新日期:1979-03-01 00:00:00

  • Corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy in simulated uterine fluid.

    abstract::Chemical immersion tests, electrochemical methods and atomic absorption spectrometry were employed to investigate the corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy (SMA) in simulated uterine fluid. The effect of pH on corrosion rate and corrosion potential was also investigated. The results indicated th...


    pub_type: 杂志文章


    authors: Chen B,Liang C,Fu D,Ren D

    更新日期:2005-09-01 00:00:00

  • Plasma levels and progestational activity of levonorgestrel after repeated intravenous and subcutaneous administration in the beagle bitch.

    abstract::In pharmacological test models providing repeated daily administrations of steroid hormones, differing time courses of the drug level depending upon the pharmacokinetics can be observed often. The present study should make a contribution to the question whether the time course of the drug level can have an influence o...


    pub_type: 杂志文章


    authors: Düsterberg B,Beier S

    更新日期:1984-04-01 00:00:00

  • The protective influence of progestogen only contraception against vaginal moniliasis.

    abstract::The incidence of Candida albicans (C.A.) infection of the vagina was evaluated in vaginal discharges obtained from 85 subjects using a large battery of culture media and confirmatory tests. Twenty women using DMPA 150 mg i.m. contraceptive injections for more than one year (long-term users) were compared with forty 2n...


    pub_type: 杂志文章


    authors: Toppozada M,Onsy FA,Fares E,Amir S,Shaala S

    更新日期:1979-08-01 00:00:00

  • A comparison of the effects of nonoxynol-9 and chlorhexidine on sperm motility.

    abstract::The effects of Nonoxynol-9 and chlorhexidine on sperm motility were compared using the objective Transmembrane Migration Ratio method. These agents were found to be of similar potency in inhibiting sperm motility. The concentrations which reduced sperm motility by 50% (EC50) were 0.205 mg/ml for Nonoxynol-9 and 0.215 ...


    pub_type: 杂志文章


    authors: Louis SM,Pearson RM

    更新日期:1985-08-01 00:00:00