Evaluation of sulprostone for second trimester abortions and its effects on liver and kidney function.

Abstract:

:Sulprostone was given intramuscularly in two dose schedules of 0.5 mg at 4 hourly intervals for 8 doses and 1.0 mg at 8-hour intervals for 4 doses to 56 women in the 12th-20th week of gestation coming for termination of pregnancy. Forty-nine of them aborted within the 30-hour observation period, giving a success rate of 87.5%. Within the observation period, the induction-abortion interval with the 0.5-mg schedule was 16.6 hours while the interval with the 1.0-mg schedule was 15.4 hours. Side effects caused by the drug were minimal and it was observed that patients receiving 1.0 mg Sulprostone had slightly more side effects per person than in those cases receiving 0.5 mg Sulprostone. Serum parameters assessing liver and kidney functions were carried out in 48 patients prior to, 24 hours later and two weeks after the abortion. There were significant changes in the levels of uric acid, potassium, serum proteins and SGOT, though these changes were within the normal range.

journal_name

Contraception

journal_title

Contraception

authors

Ranjan V,Hingorani V,Kinra G,Agarwal N,Pande Y

doi

10.1016/0010-7824(82)90028-2

subject

Has Abstract

pub_date

1982-02-01 00:00:00

pages

175-84

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010-7824(82)90028-2

journal_volume

25

pub_type

临床试验,杂志文章,随机对照试验
  • Contraceptive usage patterns in North American medical students.

    abstract:BACKGROUND:Previous studies indicate that the sexual beliefs and mores of students in medical professions may influence their capacity to care for patients' sexuality and contraception issues. Students also represent a large sample of reproductive-age individuals. In this study, we examined contraceptive usage patterns...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.09.011

    authors: Rowen TS,Smith JF,Eisenberg ML,Breyer BN,Drey EA,Shindel AW

    更新日期:2011-05-01 00:00:00

  • Use of Norplant implants in a New York City clinic population.

    abstract::Two-hundred-eight women attending family planning clinics in New York City who received the Norplant contraceptive system during the first sixteen months of Norplant implants insertions were evaluated. Within this clinic population, Norplant implants were a popular contraceptive choice and were removed from 64 of the ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(94)90096-5

    authors: Gerber S,Westhoff C,Lopez M,Gordon L

    更新日期:1994-06-01 00:00:00

  • Endometrial safety of a novel monophasic combined oral contraceptive containing 0.02 mg ethinylestradiol and 2 mg chlormadinone acetate administered in a 24/4-day regimen over six cycles.

    abstract:BACKGROUND:This study was conducted to examine whether small doses of ethinylestradiol (EE, 0.02 mg) and chlormadinone acetate (CMA, 2 mg) administered in a novel 24/4-day regimen during six cycles would suffice to suppress proliferation and to cause secretory changes in the endometrium. STUDY DESIGN:This Phase II, ra...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.04.013

    authors: Rabe T,Hartschuh E,Wahlstrom T,Höschen K,König S

    更新日期:2010-10-01 00:00:00

  • A multicenter efficacy and safety study of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol.

    abstract::The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0010-7824(92)90094-a

    authors: Walling M

    更新日期:1992-10-01 00:00:00

  • Comparison of local signs and symptoms after the insertion of Norplant implants with and without a scalpel.

    abstract::The study compares NORPLANT subdermal implants acceptors enrolled randomly for two different insertion procedures. One group (420 women) received the implants with the use of a scalpel according to the manufacturer's instructions. The other group (423 women) received the implant without an incision, directly through a...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(91)90013-6

    authors: Díaz J,Rubin J,Faúndes A,Díaz M,Bahamondes L

    更新日期:1991-09-01 00:00:00

  • Medications to ease intrauterine device insertion: a systematic review.

    abstract:BACKGROUND:Potential barriers to intrauterine device (IUD) use include provider concern about difficult insertion, particularly for nulliparous women. OBJECTIVE:This study aims to evaluate the evidence on the effectiveness of medications to ease IUD insertion on provider outcomes (i.e., ease of insertion, need for adj...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2016.06.014

    authors: Zapata LB,Jatlaoui TC,Marchbanks PA,Curtis KM

    更新日期:2016-12-01 00:00:00

  • Potential public sector cost-savings from over-the-counter access to oral contraceptives.

    abstract:OBJECTIVE:This study estimates how making oral contraceptive pills (OCPs) available without a prescription may affect contraceptive use, unintended pregnancies and associated contraceptive and pregnancy costs among low-income women. STUDY DESIGN:Based on published figures, we estimate two scenarios [low over-the-count...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.01.010

    authors: Foster DG,Biggs MA,Phillips KA,Grindlay K,Grossman D

    更新日期:2015-05-01 00:00:00

  • Extending contraceptive coverage under the Affordable Care Act saves public funds.

    abstract:BACKGROUND:The Affordable Care Act (ACA) will expand health care coverage to low-income Americans. Contraception services are a mandated component of ACA plans. STUDY DESIGN:A decision-analytic model was developed to compare the costs and outcomes of the current versus the proposed plan for contraceptive coverage (Fed...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2012.06.009

    authors: Burlone S,Edelman AB,Caughey AB,Trussell J,Dantas S,Rodriguez MI

    更新日期:2013-02-01 00:00:00

  • Effectiveness of levonorgestrel emergency contraception given before or after ovulation--a pilot study.

    abstract:BACKGROUND:Although widely used, the mechanisms of action of the levonorgestrel emergency contraceptive pill (LNG ECP) are still unclear. There are increasing data to indicate that LNG is particularly effective as an ECP by interrupting follicular development and ovulation. An important outstanding question is whether ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.contraception.2006.08.015

    authors: Novikova N,Weisberg E,Stanczyk FZ,Croxatto HB,Fraser IS

    更新日期:2007-02-01 00:00:00

  • Hemostatic and metabolic effects of lowering the ethinyl-estradiol dose from 30 mcg to 20 mcg in oral contraceptives containing desogestrel.

    abstract::The metabolic and hemostatic effects of two oral contraceptives containing 150 mcg desogestrel and 20 mcg ethinyl-estradiol (EE) (MERCILON) or 30 mcg EE (MARVELON) were compared in order to examine the effect of reducing the EE dose in contraceptive pills. Forty-nine women participated in this randomized study during ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(93)90141-s

    authors: Basdevant A,Conard J,Pelissier C,Guyene TT,Lapousterle C,Mayer M,Guy-Grand B,Degrelle H

    更新日期:1993-09-01 00:00:00

  • Intra-amniotic prostaglandin PGF2alpha (THAM salt) and the laminaria tent in midtrimester termination of pregnancy.

    abstract::20 patients underwent intraamniotic administration of PGF2alpha for termination of pregnancies ranging from 14-20 weeks gestation. Success was achieved in 18 patients (90%) with this method. The 2 failures were terminated vaginally with adjunctive use of intracervical laminaria and intravenous pitocin induction. 10...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(74)90049-3

    authors: Berman R,Hale RW,Reich LA,Pion RJ

    更新日期:1974-06-01 00:00:00

  • A Bridge for postpartum women to Standard Days Method®: I. Developing the Bridge.

    abstract:BACKGROUND:A new fertility-awareness-based Bridge was developed for postpartum women starting with their first postpartum menses and until they are eligible to use the Standard Days Method®. This article describes the development of the Bridge and theoretical efficacy. STUDY DESIGN:Analysis of a preexisting data set c...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.11.009

    authors: Sinai I,Cachan J

    更新日期:2012-07-01 00:00:00

  • Interaction of anticonvulsants and oral contraceptives in epileptic adolescents.

    abstract::Oral contraceptives are in widespread use, and are commonly prescribed for contraception in patients taking other medications. An example of this is the concomitant use of oral contraceptives and anticonvulsants in epileptic patients. This combination creates a potential for drug interactions which may alter the effic...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(85)90062-9

    authors: Diamond MP,Greene JW,Thompson JM,VanHooydonk JE,Wentz AC

    更新日期:1985-06-01 00:00:00

  • Using complete breastfeeding and lactational amenorrhoea as birth spacing methods.

    abstract::The aim of this study was to evaluate the effectiveness of lactational amenorrhoea and to determine the relationship between extended breastfeeding and the return of fertility. Breastfeeding pattern, basal body temperature, cervical mucus, salivary ferning, vaginal blood discharge, frequency of sexual intercourse, and...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(00)00101-3

    authors: Tommaselli GA,Guida M,Palomba S,Barbato M,Nappi C

    更新日期:2000-04-01 00:00:00

  • Impact of oral contraceptive use on APC-resistance: a prospective, randomized clinical trial with three low-dose preparations.

    abstract::The evaluation of the study was of the impact of oral contraceptive (OC) use on activated protein C (APC-resistance). Eight hundred eighteen young fertile women were screened for a study designed to compare three different marketed OC preparations. The women could have used either other oral contraceptive preparations...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(01)00253-0

    authors: Endrikat J,Noah M,Gerlinger C,Bannemerschult R,Junge W,Ruebig A,Schmidt W,Düsterberg B

    更新日期:2001-10-01 00:00:00

  • Women's out-of-pocket expenditures and dispensing patterns for oral contraceptive pills between 1996 and 2006.

    abstract:BACKGROUND:Little is known about the out-of-pocket expenditures and dispensing patterns for oral contraceptive pills (OCPs), factors associated with these outcomes and whether they change over time. STUDY DESIGN:Observational cohort using 1996-2006 Medical Expenditure Panel Surveys. RESULTS:Women spent $16 out-of-poc...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.09.013

    authors: Liang SY,Grossman D,Phillips KA

    更新日期:2011-06-01 00:00:00

  • Progestin-only pill use and pill switching during breastfeeding.

    abstract::The opinions of 20 international experts in reproductive endocrinology and family planning service delivery were solicited concerning contraceptive pill use during breastfeeding and, in particular, to determine whether the experts felt that breastfeeding women who use progestin-only pills (POPs) should be advised to s...

    journal_title:Contraception

    pub_type: 社论

    doi:10.1016/0010-7824(95)00076-m

    authors: Visness CM,Rivera R

    更新日期:1995-05-01 00:00:00

  • Triphasic combination of ethinyl estradiol and gestodene. Long-term clinical trial.

    abstract::A triphasic oral contraceptive containing ethinyl estradiol and gestodene was used by 1933 women for up to 36 cycles in order to evaluate contraceptive efficacy, general tolerance and cycle control. Altogether, 30,763 treatment cycles were recorded. Two pregnancies were seen, both of them classified as user failure. T...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0010-7824(92)90128-g

    authors: Weber-Diehl F,Unger R,Lachnit U

    更新日期:1992-07-01 00:00:00

  • Bleeding patterns with the levonorgestrel-releasing intrauterine system when used for heavy menstrual bleeding in women without structural pelvic pathology: a pooled analysis of randomized controlled studies.

    abstract:BACKGROUND:The study was conducted to characterize the changes in bleeding pattern over time in women receiving the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding (HMB). The reduction in menstrual blood loss volume has been well documented elsewhere. STUDY DESIGN:Post hoc pooled an...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2012.08.022

    authors: Jensen J,Mansour D,Lukkari-Lax E,Inki P,Burock K,Fraser IS

    更新日期:2013-01-01 00:00:00

  • Emergency contraception in Albania: a multimethods qualitative study of awareness, knowledge, attitudes and practices.

    abstract:OBJECTIVES:Contraceptive prevalence is relatively low in Albania, and abortion is the mainstay of family planning. Although levonorgestrel-only emergency contraceptive pills are available, uptake of this method is minimal. Emergency contraception (EC) could play a significant role in addressing women's need for an effe...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.03.033

    authors: Doci F,Thaci J,Foster AM

    更新日期:2018-04-11 00:00:00

  • Emergency contraception in Mexico City: what do health care providers and potential users know and think about it?

    abstract::Emergency contraception promises to reduce Mexico's high unwanted pregnancy and unsafe abortion rates. Because oral contraceptives are sold over-the-counter, several emergency contraceptive regimens are already potentially available to those women who know about the method. Soon, specially packaged emergency contracep...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(99)00088-8

    authors: Langer A,Harper C,Garcia-Barrios C,Schiavon R,Heimburger A,Elul B,Renoso Delgado S,Ellertson C

    更新日期:1999-10-01 00:00:00

  • Release kinetics of 3-keto-desogestrel from contraceptive implants (Implanon) in dogs: comparison with in vitro data.

    abstract::Ethylene-vinyl acetate (EVA) polymeric contraceptive implants (Implanon) containing 3-keto-desogestrel have been prepared aiming at an in vitro initial release rate of 60 micrograms 3-keto-desogestrel/day. These implants are designed to have an intended life-time of 2 years. During a 3-year period, the release of thes...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(93)90093-m

    authors: Geelen JA,van der Wardt JT,Voortman G,Maassen GC,Eenink MJ

    更新日期:1993-02-01 00:00:00

  • Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.

    abstract:BACKGROUND:This study investigated the effects of adding levomefolate calcium 0.451 mg (the calcium salt of L-5-methyltetrahydrofolate; Metafolin®) to an oral contraceptive containing ethinylestradiol (EE) 20 mcg/drospirenone (drsp) 3 mg on folate levels in healthy women seeking contraception. STUDY DESIGN:In this ran...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2011.05.013

    authors: Bart S Sr,Marr J,Diefenbach K,Trummer D,Sampson-Landers C

    更新日期:2012-01-01 00:00:00

  • Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment.

    abstract::After exposure of young male rats to gossypol acetic acid for various times, a reduction in the content of cellular and microtubular beta-tubulin was found in spermatocytes and spermatids. The content of tubulin was measured by enzyme-linked immunosorbent assay (ELISA). The results were expressed as micrograms tubulin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(96)00240-5

    authors: Teng CS

    更新日期:1997-01-01 00:00:00

  • Minimal androgenic activity of a new oral contraceptive containing norethindrone acetate and graduated doses of ethinyl estradiol.

    abstract::The pharmacokinetics and androgenic activity of Estrostep, a new oral contraceptive providing low-dose estrogen in a graduated sequence with a constant dose of progestin, were characterized in an open-label, nonrandomized study in 17 normally cycling women treated for three cycles with Estrostep. Women received 1 mg o...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(01)00179-2

    authors: Boyd RA,Zegarac EA,Posvar EL,Flack MR

    更新日期:2001-02-01 00:00:00

  • Acceptability of the vaginal sheath (Femshield) in Thai couples.

    abstract::A small survey to assess the perception and experience of current family planning users and their husbands was carried out in a university family planning clinic. Women routinely visiting the clinic were asked to complete a short Screening Form. Fifty-six women responded to the questionnaire concerning their attitude ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90118-y

    authors: Jivasak-Apimas S

    更新日期:1991-08-01 00:00:00

  • Interval iud insertion in parous women: a randomized multicentre comparative trial of the Lippes Loop D, TCu220c and the Copper 7.

    abstract::A multicentre randomized clinical trial of the TCu220C, Lippes Loop D and Copper 7 was undertaken in nine WHO Collaborating centres for Clinical Research in Human Reproduction. A total of 984, 992 and 994 devices, respectively, were inserted between 1976 and 1978. The subjects were followed for two years. At this time...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(82)90167-6

    authors:

    更新日期:1982-07-01 00:00:00

  • Inhibition of implantation by the intrauterine administration of phospholipases in the rat.

    abstract::Phospholipases A2 and C (93 and 500 mU) were administered to uterine horns of Long-Evans adult rats during the first five days of pregnancy. As control material, saline (0.15 M) was administered to contralateral uterine horns. The animals were sacrificed on the ninth day of pregnancy, the uterine horns were removed an...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(82)90023-3

    authors: Vilar-Rojas C,Ruiz de Chávez I,González-Angulo A,Hicks JJ

    更新日期:1982-01-01 00:00:00

  • Contraception services for incarcerated women: a national survey of correctional health providers.

    abstract:BACKGROUND:Incarcerated women have had limited access to health care prior to their arrest. Although their incarceration presents an opportunity to provide them with health care, their reproductive health needs have been overlooked. STUDY DESIGN:We performed a cross-sectional study of a nationally representative sampl...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2009.05.126

    authors: Sufrin CB,Creinin MD,Chang JC

    更新日期:2009-12-01 00:00:00

  • In vivo measurements of uterine cavities in 795 women of fertile age.

    abstract::The uterine sound length, the functional length of the cervix including the zone of internal cervical os and the fundus transversal were determined in 795 fertile women in vivo using a measuring device, the Cavimeter. The functional cavity length was calculated by subtracting the functional length of the cervix from t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(84)80011-6

    authors: Kurz KH,Tadesse E,Haspels AA

    更新日期:1984-06-01 00:00:00