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Prazosin, an adrenergic blocking agent inadequate as male contraceptive pill.

Abstract：

:The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the male genital tract is an interesting approach. Prazosin administered in doses up to 10 mg/day did not cause azoospermia following ejaculation. In conclusion, we have not been able to confirm either the efficacy or the acceptability of the alpha 1-adrenoceptor antagonist Prazosin as a male contraceptive drug. Homonnai et al. confirmed the fact that phenoxybenzamine blocks ejaculation, but it should be noted that although both drugs are alpha 1-adrenoceptor blocking agents, they are not chemically identical. :The efficacy and acceptability of the adrenoceptive-blocking agent, Prazosin, as a male contraceptive pill were investigated in 10 healthy men who had been referred for sexual sterilization. Prazosin was administered by mouth twice a day at a dosage that was increased from 0.5 mg to a maximum of 5.0 mg for an average of 40 days (range 5-110 days). No significant differences were recorded in pretreatment and post-treatment values for semen volume or sperm concentration. Nor were there any significant changes in sperm penetration or motility as a result of treatment with Prazosin. No changes were noted in either blood chemistry or blood pressure. Postejaculation urine collected to detect possible signs of retrograde ejaculation contained no spermatozoa. 5 (50%) of volunteers complained of side effects, including minor vertigo, palpitation, and generalized discomfort. Overall these findings failed to confirm either the efficacy or the acceptability of Prazosin as a male contraceptive drug. Another adrenoceptive antagonist, phenoxybenzamine, has been shown to be an effective antifertility agent without significant side effects at doses as high as 30 mg/day. However, it should be noted that this agent is not chemically identical to Prazosin.

journal_name

Contraception

journal_title

Contraception

authors

Kjaergaard N,Kjaergaard B,Lauritsen JG

doi

10.1016/0010-7824(88)90008-x

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

621-9

issue

eissn

0010-7824

issn

1879-0518

pii

0010-7824(88)90008-X

journal_volume

pub_type

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Prazosin, an adrenergic blocking agent inadequate as male contraceptive pill.