Abstract：
:Saponins isolated from Sapindus mukorossi have potent spermicidal activity. Morphological changes in human ejaculated spermatozoa after exposure to these saponins were evaluated under Scanning Electron Microscope. The minimum effective concentration (0.05% in spot test) did not affect the surface topography after exposure for 1 minute. However, incubation of spermatozoa for 10 minutes resulted in extensive vesiculation and disruption of plasma membrane in the head region. Higher concentrations (0.1%, 1.25%, 2.5% and 5.0%) caused more or less similar changes which included vesiculation, vacuolation, disruption or erosion of membranes in the head region. These findings suggest that the morphological changes observed are due to alterations in the glycoproteins associated with the lipid bilayer of plasma membrane of spermatozoa.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Dhar JD,Bajpai VK,Setty BS,Kamboj VPdoi
10.1016/0010-7824(89)90111-xsubject
Has Abstractpub_date
1989-05-01 00:00:00pages
563-8issue
5eissn
0010-7824issn
1879-0518pii
0010-7824(89)90111-Xjournal_volume
39pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:The continuation rate at the end of this five-year clinical study was 60% with no accidental pregnancy occurring throughout the five years. The post-removal conception rate in women desiring pregnancy was 92% at the end of two years. The majority of acceptors described the overall experience with the implants as favou...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90139-k
更新日期：1992-01-01 00:00:00
abstract：:Eighty-four Chinese patients attending the Family Planning Association of Hong Kong for contraception with oral contraceptive pills were randomized into 2 groups. The first group received pills containing 0.15 mg levonorgestrel and 0.03 mg ethinyl oestradiol. The second group received pills containing 0.15 mg desogest...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(90)90126-g
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The study was conducted to determine the impact of switching from oral to transdermal patch or vaginal ring contraception on biomarkers of thrombosis. STUDY DESIGN:Current healthy oral contraceptive (OC) users were randomized to switch to either a contraceptive ring (CR) or patch (CP) and underwent phleboto...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2008.07.004
更新日期：2008-12-01 00:00:00
abstract：:The requirement that every woman desiring medical abortion must come in person to a clinical facility to obtain the drugs is a substantial barrier for many women. To eliminate this requirement in the United States, two key components of the standard initial visit would need to be restructured. First, alternatives to u...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2015.06.020
更新日期：2015-09-01 00:00:00
abstract：:The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(94)90019-1
更新日期：1994-10-01 00:00:00
abstract：:Scarce data are available on the relation between the effectiveness of intrauterine device (IUD) and the gynecologic features of a woman. A nested case-control study was conducted to determine whether the uterine position and hysterometry affect the pregnancy rate of copper IUD. Seventy-one cases (pregnant women with ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00480-8
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVE:To understand teen birth trends in Georgia by racial and geographic factors. STUDY DESIGN:We analyzed overall birth and repeat teen birth rates by race, urban/rural status and adequacy of obstetric care from 2008 to 2016 using vital records from all Georgia counties. RESULTS:Overall birth rates among teens ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2018.11.007
更新日期：2019-03-01 00:00:00
abstract：:This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2011.01.021
更新日期：2011-05-01 00:00:00
abstract：:There is concern that the breast-fed infant whose mother is receiving intra-muscular progestogens for contraception will be exposed to significant quantities of the steroid. Norethisterone levels in maternal serum and milk were studied throughout an injection interval after intramuscular administration of 200mg noreth...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(83)90073-2
更新日期：1983-11-01 00:00:00
abstract：OBJECTIVES:Combined oral contraceptives (COCs) decrease testosterone (T) levels. This study investigated restoration of T and other androgen concentrations during COC use by 'co-administration' of dehydroepiandrosterone (DHEA). STUDY DESIGN:In this randomized, double-blind, placebo-controlled study in 99 new COC start...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2014.11.002
更新日期：2015-02-01 00:00:00
abstract：:In Lebanon, coitus interruptus or withdrawal remains a widely practiced method of family planning. Our research sought to understand the role of men in reproductive health in Lebanon by focusing on this common practice. Our main questions were: Why is it that the practice persists when more effective modern methods of...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00304-3
更新日期：2002-02-01 00:00:00
abstract：OBJECTIVE:The study was conducted to evaluate the effect of Carraguard vaginal gel containing 0.75 mg of levonorgestrel (CARRA/LNG gel) administered in a single dose at different stages of follicle development over subsequent follicle rupture and hormonal levels. METHOD:Randomized, blinded, cross-over study comparing ...
journal_title：Contraception
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.contraception.2007.04.005
更新日期：2007-08-01 00:00:00
abstract：:A large introductory study of Cyclofem, a once-a-month injectable contraceptive, was conducted in three Mexican provinces. A total of 3457 healthy women participated: 640 women from rural areas (community-based component) and 2817 women from urban and suburban areas (health center-based component). A total of 20,316 w...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(98)00062-6
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.08.016
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Whether contraception affects health-related quality of life (HRQoL) is unclear. STUDY DESIGN:We conducted a cross-sectional analysis of routine intake data collected from women aged 18-50 years, including the RAND-36 (Research and Development Corporation) measure of HRQoL, pregnancy intentions and recent c...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2011.08.004
更新日期：2012-03-01 00:00:00
abstract：:Hsp70-2 functions as a molecular chaperone that assists other proteins in their folding, transport and assembly into complexes, and is postulated to be linked to the mechanisms that inhibit apoptosis. Here we have determined the association between Hsp70-2 gene and germ cell apoptosis induced by a high dose of testost...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00357-8
更新日期：2002-11-01 00:00:00
abstract：:The possibility of permanent sterility following use of modern contraceptive agents is a concept which causes great concern amongst members of the lay public. However, a thorough review of the literature gives a great deal of reassurance on this topic. The combined oral contraceptive pill causes slight delay, and the ...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(82)90105-6
更新日期：1982-10-01 00:00:00
abstract：:Oral contraceptives (OCs) have been shown to effectively treat acne. Clinical trials of various doses of ethinyl estradiol (EE) combined with progestins such as levonorgestrel, desogestrel, norgestimate, gestodene, cyproterone acetate and drospirenone in monophasic, triphasic and combiphasic formulations used to treat...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2005.07.010
更新日期：2006-01-01 00:00:00
abstract：:The separate effect of ethinylestradiol (4 micrograms/kg b.w./day) and d-norgestrel (20 micrograms/kg b.w./day) on the fibrinolytic activity in plasma and in vessel walls of the hind leg was investigated in an experimental study on rats. No hormonal effect on the fibrinolytic activity in plasma was registered. However...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(84)90101-x
更新日期：1984-08-01 00:00:00
abstract：:To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(72)90011-x
更新日期：1972-06-01 00:00:00
abstract：:To determine the safety of transcervical administration of quinacrine pellets as a method of voluntary female sterilization, three noncomparative Phase I clinical trials of the administration of 250 mg quinacrine were carried out in 21 women who were scheduled to undergo hysterectomy 24 h or one month later. Detailed ...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(96)00174-6
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:While the intra-uterine device (IUD) is the second most popular contraceptive method in France, its use remains low among women most at risk of unintended pregnancies. Acknowledging the conjoint role of women and physicians in contraceptive decision making, we investigate the determinants of IUD use and IUD r...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2013.10.003
更新日期：2014-01-01 00:00:00
abstract：:The rheological properties of four commercially available spermicidal gels (two polyacrylic acid derivatives and two carboxymethylcellulose based) and their dilutions with a vaginal fluid simulant (pH 4.2) and a semen simulant (pH 7.7) were measured at 25 degrees C and 37 degrees C over a biologically relevant range o...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00430-4
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:The risk of pregnancy is estimated to be 20 times as high among women who use oral contraception, and 90 times as high among condom users, as among women who use certain long-acting contraceptive methods. We explored the population-level implications of this variation in contraceptive efficacy. STUDY DESIGN...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.03.014
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To explore perspectives on family planning among young people who perceive they are infertile or will have difficulty carrying a pregnancy to term owing to medical conditions or procedures. METHODS:This exploratory analysis examined pregnancy plans and contraceptive behavior among 12 young adults with a diag...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.03.046
更新日期：2019-07-01 00:00:00
abstract：:Changes in the physical characteristics of semen and ultrastructure of the spermatozoa of langur monkeys after vas occlusion with styrene maleic anhydride (SMA), a polymer with pH-lowering action, are reported. Vas occlusion resulted in severe reversible hypospermia. Severe oligospermia was observed in the majority of...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(98)00011-0
更新日期：1998-02-01 00:00:00
abstract：:Mature epididymal boar spermatozoa converted fructose, glycerol and glycerol-3-phosphate to carbon dioxide, but in the presence of 0.5 mM 3-bromopyruvate, these oxidations were inhibited while that of lactate was unaffected. Inhibition of the oxidation of these substrates results in a decrease in the content of ATP an...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(95)00217-x
更新日期：1995-11-01 00:00:00
abstract：:Histopathological and biochemical effects of gossypol acetate (GA) on pituitary-gonadal axis were investigated. 10 and 25 mg GA/kg were administered orally to sexually mature adult male Wistar rats for 4 and 5 weeks, respectively. STH and LTH/PRL cells showed no significant changes as compared to those of controls whi...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90162-m
更新日期：1992-05-01 00:00:00
abstract：:Levels of contraceptive steroids in breast milk and plasma of lactating women were investigated. 7 lactating women received 150 mg medroxyprogesterone acetate (MPA) 1 week after delivery. 5 women (lactating) took 350 mcg norethisterone (NET) and 2 took 150 mcg d-norgestrel (d-ng) + 30 mcg ethinyl estradiol. Milk an...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(77)90061-0
更新日期：1977-12-01 00:00:00
abstract：OBJECTIVE:Female sterilization is one of the most prevalent methods of contraception in the United States. Prior studies have shown that nearly half of postpartum tubal ligation (PPTL) requests go unfulfilled. This study seeks to establish whether obstetric or medical risk status influences patients' request for or sub...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2016.08.009
更新日期：2017-03-01 00:00:00
