Abstract：
:Mature epididymal boar spermatozoa converted fructose, glycerol and glycerol-3-phosphate to carbon dioxide, but in the presence of 0.5 mM 3-bromopyruvate, these oxidations were inhibited while that of lactate was unaffected. Inhibition of the oxidation of these substrates results in a decrease in the content of ATP and the accumulation of dihydroxyacetone phosphate and fructose-1,6-bisphosphate. Examination of the activities of the enzymes within stage two of the glycolytic pathway showed that glyceraldehyde-3-phosphate dehydrogenase and 3-phosphoglycerate kinase were immediately inhibited by 3-bromopyruvate in a competitive manner. We now report the action of 3-bromopyruvate on the metabolic activity of boar spermatozoa. At a concentration of 0.5 mM, this compound selectively inhibits stage two of the glycolytic pathway and becomes yet another specific inhibitor of spermatozoal metabolism.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Jones AR,Gillan L,Milmlow Ddoi
10.1016/0010-7824(95)00217-xsubject
Has Abstractpub_date
1995-11-01 00:00:00pages
317-20issue
5eissn
0010-7824issn
1879-0518pii
001078249500217Xjournal_volume
52pub_type
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