Abstract：
:To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were conducted: 1) to test NET effect on progesterone and estradiol levels, and 2) to test NET contraceptive efficacy and side effects. Daily blood samples of the 10 volunteers under treatment with various doses (5-100 mg) of NET revealed that plasma levels of the 2 steroids were drastically reduced. In the second study, 80 volunteers were followed through 301 menstrual cycles. A total oral dose of 200 mg of NET was used in 2 different postovulatory schedules. 70% of the cycles were ovulatory; control of vaginal bleeding was good; side effects were minor. 22 pregnancies resulted, which is lower than the average number of expected pregnancies from unprotected coitus for that group of women. Despite this mild contraceptive effect, the efficacy of NET is hardly sufficient using this experimental model. The NET treatment does appear contraceptively effective if administered before implantation, and further research with a different experimental design is indicated.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Nygren KG,Johansson ED,Wide Ldoi
10.1016/0010-7824(72)90011-xsubject
Has Abstractpub_date
1972-06-01 00:00:00pages
445-56issue
6eissn
0010-7824issn
1879-0518pii
0010-7824(72)90011-Xjournal_volume
5pub_type
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