Abstract:
:The influence of copper ions on myometrial activity was tested in nonpregnant rabbits in vitro and in vivo, and nonpregnant women in vivo. In an organ bath, CuCl2 in concentrations of 3 micro M and higher caused a dose-dependent increase in the contractile activity of isolated rabbit myometrium. In rabbits in vivo, intrauterine instillations of 0.2 to 2 mM of CuCl2 in 0.6 ml of saline solution caused a dose-dependent increase of myometrial activity in the uterine horn where it was injected, and the response lasted up to 30 minutes. The activity in the other horn remained unchanged and control injections with saline had no effect. Also, in nonpregnant women, a clear and dose-dependent effect of 1 ml of 0.3 to 3 mM of CuCl2 dissolved in saline was observed after intrauterine instillation. Saline itself in the same volume had no effect. It is estimated that the intrauterine doses of copper which were used in these experiments lead to Cu++ concentrations in the uterine tissues which were similar to those in women carrying a copper IUD, and it is suggested that the copper from such IUDs might have effects on myometrial activity contributing to the contraceptive action and to some of the side-effects of these devices. :A study was conducted to determine the influence of copper ions in nonpregnant rabbits "in vitro" and "in vivo" and in nonpregnant women "in vivo." 25 nonpregnant does of Polish strain were housed under standardized conditions of light and feeding. Myometrium from 10 rabbits was used for "in vitro" experiments; the other animals were studied "in vivo." 6 nonpregnant, parous, and gynecologically healthy women of reproductive age participated in the study. The experiments were done within 3 days before onset of menstruation, and the recording sessions lasted for about 3 hours. In the nonpregnant rabbits "in vitro," a clear increase of the amplitude and frequency of contractions was observed with concentrations of CuC12 as low as 3 mcM in the bath fluid. An elevation of the basal tone was observed and with concentrations of 30 mcM and higher a sustained contraction generally occurred. Intravenous injections of 1 ml of CuC12 solution at a concentration of 2mcM were given to 5 rabbits "in vivo." There was no consistent effect on myometrial activity or on arterial blood pressure. A volume of 0.6 ml of saline per se had no effect on the uterine activity in 10 "in vivo" rabbits. CuC12 dissolved in the same volume of saline in concentrations of 0.2 mM resulted in an increase in uterine activity in the majority of rabbits. With 2.0 mM of CuC12 the effect was pronounced in all does. In nonpregnant women a clear and dose-dependent effect of 1 ml of 0.3-3 mM of CuC12 dissolved in saline was observed after intrauterine instillation. Saline itself in the same volume had no effect. It is estimated that the intrauterine doses of copper which were used in these experiments lead to Cu++ concentrations in the uterine tissues which were similar to those in women carrying a copper IUD. The copper from such IUDs might have effects on myometrial activity contributing to the contraceptive action and to some of the side-effects from copper IUDs.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Laundański T,Kobylec E,Akerlund Mdoi
10.1016/0010-7824(81)90092-5subject
Has Abstractpub_date
1981-08-01 00:00:00pages
195-202issue
2eissn
0010-7824issn
1879-0518pii
0010-7824(81)90092-5journal_volume
24pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract:BACKGROUND:Women with cardiac disease have need for effective long-lasting reversible contraception. Women with cardiac disease are at increased risk for bacterial endocarditis. There is limited research regarding the use of intrauterine contraceptive devices (IUD) in women with cardiac disease. STUDY DESIGN:In a pros...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2008.05.006
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:Pharmacokinetics of norethindrone in combination oral contraceptive regimen are well described among HIV+ women treated with ritonavir-boosted protease inhibitor therapies; however, such characterization is lacking in women using progestin-only contraception. Our objective is to characterize pharmacokinetics ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.08.009
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk of venous thromboembolism (VTE) in young women. A 5-year case-control study including all Danish hospitals was conducted. All women 15-44 years old, suffering a first ever deep venous thrombosis or a first pulmonary emboli...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(01)00307-9
更新日期:2002-03-01 00:00:00
abstract::In a study of 1074 women, 696 and 338 subjects would not seriously consider permanent and hypothetically reversible sterilization, respectively; they were asked to explain their feelings. The reason accounting for most objections to permanent sterilization (65%) was irreversibility and of the subjects who would not co...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(80)80001-1
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND:Highly effective contraception is essential in obese women, but it should not increase their risk of developing or worsening obesity-related cardiometabolic illness. The purpose of this 18-week prospective experimental study was to compare the impact of subcutaneous depot medroxyprogesterone acetate (DMPA-SC...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2011.04.016
更新日期:2012-01-01 00:00:00
abstract::Research has established the principle of hormonal male contraception based on suppression of gonadotropins and spermatogenesis. All hormonal male contraceptives use testosterone, but only in East Asian men can testosterone alone suppress spermatogenesis to a level compatible with contraceptive protection. In Caucasia...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.03.020
更新日期:2010-11-01 00:00:00
abstract::A prospective randomized trial was conducted in 140 women to compare the efficacy of vaginal gemeprost with vaginal misoprostol for termination of second trimester pregnancy. Women requesting termination of second trimester pregnancy were randomized into two groups. Group A women were given 1 mg vaginal gemeprost ever...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(98)00099-7
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:The purpose of this pilot project was to test the feasibility of a technique designed to place a copper intrauterine device (IUD) through the hysterotomy incision of an elective cesarean delivery to minimize possible contamination and to guarantee that tailstrings were visible in the vagina for easy removal ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2009.01.014
更新日期:2009-07-01 00:00:00
abstract::The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(87)90077-1
更新日期:1987-04-01 00:00:00
abstract::Pituitary and ovarian function was evaluated in women receiving 3 combined oral contraceptive preparations. Basal levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) and gonadotropic responses to gonadotropic releasing hormone (GnRH) were studied in 36 healthy, regularly ovulating women in the ea...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(81)90089-5
更新日期:1981-08-01 00:00:00
abstract::Medication abortion, also referred to as medical abortion, is a safe and effective method of providing abortion. Medication abortion involves the use of medicines rather than uterine aspiration to induce an abortion. The U.S. Food and Drug Administration (FDA)-approved medication abortion regimen includes mifepristone...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.08.004
更新日期:2020-10-01 00:00:00
abstract::Since peritubular smooth muscle cells (PSMCs) have been characterized, isolated and cultured in homogeneous populations, the regulation of seminiferous epithelium contractility has received increasing attention. The present article reports and discusses experimental evidence demonstrating that: (1) PSMCs express two t...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/s0010-7824(01)00319-5
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:This study compared adherence to follow-up and clinical outcomes between standard in-clinic and remote follow-up after methotrexate/misoprostol abortion. STUDY DESIGN:This nonrandomized trial recruited women requesting medical abortion at two sexual health clinics in Toronto, Canada. Women received methotrex...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2015.05.013
更新日期:2015-09-01 00:00:00
abstract::Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90005-7
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effectiveness of a refined theory-based Interactive Postpartum Sexual Health Education Program to enhance postpartum women's effective contraceptive behavior. STUDY DESIGN:Participants (N=250) were randomized to three groups. Experimental Group A received our interv...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2010.11.008
更新日期:2011-07-01 00:00:00
abstract::RU 486 and three of its metabolites (RU 42633-monodemethyl, RU 42848-didemethyl, and RU 42698-hydroxymetabolite) were determined by HPLC in plasma from nine non-pregnant and 36 pregnant women. Each non-pregnant subject took an oral dose of RU 486 (25, 100, 400 and 600 mg consecutively) once per menstrual cycle. Six of...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(93)90004-q
更新日期:1993-08-01 00:00:00
abstract::To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(72)90011-x
更新日期:1972-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the presence of ovarian cysts in women using a new low-dose levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 13.5mg [total content]). STUDY DESIGN:A Phase 3 study assessed LNG-IUS 13.5mg use in healthy women with regular menstrual cycles who requested co...
journal_title:Contraception
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.contraception.2015.01.021
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The objective was to determine the effect of routine, opt-out abortion and family planning training on clinical exposure to uterine evacuation, contraception and other gynecologic skills. METHODS:Data from the first 10 years of the Kenneth J. Ryan Residency Training Program in Abortion and Family Planning we...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.02.006
更新日期:2013-08-01 00:00:00
abstract::9-Deoxo-16, 16-dimethyl-9-methylene-PGE2 is a new prostaglandin analogue which is stable in suppository form. Estimates of potential for gastrointestinal side effects in monkey in vivo indicated that the frequency of diarrhea was low with retention of uterine stimulating potency. In the present study the effect of the...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90059-1
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2016.06.012
更新日期:2016-12-01 00:00:00
abstract::Fifty-six women using depot-norethisterone enanthate injections for contraception for 2 years or more were compared with a control group of 48 women not using hormonal contraception. No significant difference was found between the study group and controls for Factors VIIc and Antithrombin III. Factor Xc was reduced in...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(91)90083-r
更新日期:1991-12-01 00:00:00
abstract::In a cross-over study with orally administered desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) and 3-keto-desogestrel (0.150 mg) plus ethinyloestradiol (0.030 mg) in ten women under steady-state conditions, the serum levels of 3-keto-desogestrel were monitored by radioimmunoassay. No statistically significant...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90047-8
更新日期:1986-06-01 00:00:00
abstract::This was a dual-cohort study performed to determine if, by using methotrexate alone, abortions could be induced with fewer side effects, without sacrificing effectiveness and patient satisfaction. The subjects were 358 consecutive patients who requested elective medical termination of pregnancy at < 7 weeks gestation....
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/s0010-7824(98)00146-2
更新日期:1999-01-01 00:00:00
abstract::An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(82)90146-9
更新日期:1982-11-01 00:00:00
abstract::Levels of immunoreactive follitropin (FSH), lutropin (LH), estradiol, progesterone, 17-hydroxyprogesterone and 20 alpha-dihydroprogesterone were analyzed in peripheral plasma samples collected daily from 21 normally menstruating women during a pretreatment (control) cycle and during months 2 and 6 of administration of...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(81)90049-4
更新日期:1981-03-01 00:00:00
abstract::A polyethylene intrauterine device (IUD) inserted in one horn of the rat uterus on Day 2 of pregnancy prevented implantation in 9 out of 12 rats in the horn with the device. When polyphloretin phosphate (PPP), a substance known to inhibit alkaline phosphatase, was administered to such rats from Day 1 till Day 5 of pre...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90016-1
更新日期:1983-08-01 00:00:00
abstract::A randomised cross-over trial was performed to compare the pharmacodynamic actions of three low-dose oral contraceptives (OCs): Marvelon (150 micrograms desogestrel (DSG)+ 30 micrograms ethinyloestradiol (EE)), Mercilon (150 micrograms DSG + 20 micrograms EE) and Microgynon (150 micrograms levonorgestrel (LNG) + 30 mi...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0010-7824(92)90103-z
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:To describe real-world care seeking and contraception provision in one direct to consumer telemedicine platform. STUDY DESIGN:We described encounters with reproductive age female patients between July 2016 and July 2018 seeking contraception on the American Well telemedicine platform. RESULTS:Of 126,712 tot...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.01.017
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Higher rates of unwanted pregnancies and lower rates of contraceptive use have been reported among Hispanic women than among non-Hispanic whites. Despite these differences, it is unclear how these groups differ with respect to various psychosocial factors that are associated with contraceptive decision makin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2006.02.010
更新日期:2006-08-01 00:00:00