当前位置： SCI文献检索 > CONTRACEPTION期刊下所有文献 > Effects of ethinyl estradiol and ibuprofen compared to placebo on endometrial bleeding, cervical mucus and the postcoital test in levonorgestrel subcutaneous implant users.

Effects of ethinyl estradiol and ibuprofen compared to placebo on endometrial bleeding, cervical mucus and the postcoital test in levonorgestrel subcutaneous implant users.

Abstract：

BACKGROUND:The study was conducted to evaluate ethinyl estradiol (EE) or ibuprofen (IBU) compared to placebo (PL) on spotting and bleeding (S/B) and a postcoital test (PCT) in women using the levonorgestrel subcutaneous implant. Women experiencing excessive S/B were enrolled in a multicenter prospective randomized study using EE, IBU or PL. OUTCOME MEASURES:Duration of S/B and a PCT were evaluated. Statistical analysis used a general linear model procedure with Duncan's multiple range tests for individual variables. RESULTS:One hundred seven women were evaluated, and there was no difference in the duration of bleeding among the three therapies, while the mean number of spotting days were 1.8 for EE and 2.8 for PL (p=.04). There was no effect of IBU on S/B. No effect on cervical mucus or sperm was found between treatments. CONCLUSION:There was a decrease in spotting but no effect on bleeding with EE compared to PL.

journal_name

Contraception

journal_title

Contraception

authors

Archer DF,Philput CB,Levine AS,Cullins V,Stovall TG,Bacon J,Weber ME

doi

10.1016/j.contraception.2008.04.003

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

106-12

issue

2

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(08)00160-1

journal_volume

78

pub_type

杂志文章,多中心研究,随机对照试验

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