Abstract：
:A polyethylene intrauterine device (IUD) inserted in one horn of the rat uterus on Day 2 of pregnancy prevented implantation in 9 out of 12 rats in the horn with the device. When polyphloretin phosphate (PPP), a substance known to inhibit alkaline phosphatase, was administered to such rats from Day 1 till Day 5 of pregnancy, the device prevented implantation in only 3 out of 12 rats in the horn with the device. PPP also significantly reduced the raised levels of endometrial alkaline phosphatase observed in the presence of the device. A significant rise in endometrial alkaline phosphatase was seen in such animals not administered PPP. It is suggested that there is a correlation between the anti-implantation effect of an IUD and raised levels of endometrial alkaline phosphatase in rats.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Chaudhury MRdoi
10.1016/0010-7824(83)90016-1subject
Has Abstractpub_date
1983-08-01 00:00:00pages
171-9issue
2eissn
0010-7824issn
1879-0518pii
0010-7824(83)90016-1journal_volume
28pub_type
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