Abstract：
:This study examines the efficacy and side effects of 15-methyl-prostaglandins F2alpha (PGF2a) free acid administered intramuscularly for midtrimester abortion. 50 healthy women aged 14 to 37 years and between 12 to 18 weeks gestation were randomly selected from the abortion clinic at the Los Angeles County/USC Medical Center, Women's Hospital to participate in the study. The prostaglandin preparation was supplied in ampules containing 1.1 mg. in 2.2 ml. of aqueous solution. The injection was given every 2 hours until the fetus was expelled or for a maximum of 12 injections. Vital signs of the patients were closely monitored. 46% (23) of the subjects aborted within 12 hours and 90% within 27 hours. Mean injection-abortion time was 13.5 hours (range, 5 3/4 to 27 hours). The effectiveness and rapidity of abortion was related with gestational age: the lower the gestational age, the shorter the abortion time. Women with more than 17 weeks gestation had a higher failure rate. Mean number of injections was 7.5. 5 patients failed to abort with prostaglandin alone, all of them primigravidas and weighing in excess of 150 lbs; supplemental therapy was provided. Side effects and complications associated with 15-methyl-PGF2a included: emesis (66%); diarrhea (76%); flushing (12%); chills (4%); fever of 100 degrees Fahrenheit (12%); pain requiring medication (16%); and blood loss (6%). The success of this method appears to be related to dosage; parity; gestational age; weight of patient; and frequency of administration. Although there were side effects, these were outweighed by rapid abortion time, mild contractions, and ease of administration. Asthma is the only medical contraindication to prostaglandin therapy.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Slaughter L,Ballard CAdoi
10.1016/0010-7824(75)90107-9subject
Has Abstractpub_date
1975-05-01 00:00:00pages
533-40issue
5eissn
0010-7824issn
1879-0518pii
0010-7824(75)90107-9journal_volume
11pub_type
杂志文章相关文献
CONTRACEPTION文献大全abstract：:A five-year study of NORPLANT II rod implants was undertaken in four large cities and metropolitan areas in eastern China. Designed to test the safety, efficacy and acceptability of these implants, the study involved 1,208 women and was conducted concurrently with a similar study of NORPLANT capsule implants. At the e...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(94)90078-7
更新日期：1994-07-01 00:00:00
abstract：:This report describes the long-term follow-up of 376 women who received NORPLANT implants in the period October 1974 through May 1979. One-hundred-and-ten subjects received replacement implants after variable lengths of use of the first set. The average levonorgestrel plasma levels declined steadily through eight year...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(87)80016-1
更新日期：1987-06-01 00:00:00
abstract：BACKGROUND:The purpose of this pilot project was to test the feasibility of a technique designed to place a copper intrauterine device (IUD) through the hysterotomy incision of an elective cesarean delivery to minimize possible contamination and to guarantee that tailstrings were visible in the vagina for easy removal ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2009.01.014
更新日期：2009-07-01 00:00:00
abstract：:Mifepristone medical abortion has been a valuable addition to the reproductive health options of women. Aspects of its provision have however sometimes limited its accessibility and use. This article summarizes existing evidence for simplifying the provision of medical abortion and thus increasing its availability. We...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2006.11.011
更新日期：2007-04-01 00:00:00
abstract：:As part of a 60-week, open-label, nonrandomized, parallel, controlled study comparing a monthly contraceptive injection containing medroxyprogesterone acetate (MPA) 25 mg and estradiol cypionate (E(2)C) 5 mg (Lunelle Monthly Contraceptive Injection) and a norethindrone 0.5, 0.75, 1.0 mg/0.035 mg ethinyl estradiol (NET...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(99)00114-6
更新日期：2000-01-01 00:00:00
abstract：:The purpose of the study was to evaluate semen quality in young Chinese men and to establish reference values. Normal healthy young men from seven geographical areas were enrolled. The study showed that the mean sperm volume was 2.61 mL, and mean percent of sperm with forward progression was 59.89, while median of sem...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00281-0
更新日期：2002-05-01 00:00:00
abstract：:DL111-IT, a non-hormonal contragestional agent, revealed synergistic effects in combination with mifepristone (RU486) in some species. The present study was undertaken to clarify the role of DL111-IT when used alone or plus RU486 on uterine polyamines biosynthesis, histologic alteration of decidual cells, and antifert...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(01)00197-4
更新日期：2001-05-01 00:00:00
abstract：:We evaluated the efficacy and side effects of immediate postcoital administration of levonorgestrel 0.75 mg used repeatedly for contraception. A total of 295 healthy women with infrequent coitus were enrolled at 6 study sites. Each woman took levonorgestrel 0.75 mg by mouth immediately after intercourse during 6 month...
journal_title：Contraception
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Maternal trisomy 21 ovarian mosaicism might provide the major causative factor for fetal Down syndrome. The small proportion of trisomy 21 oocytes thought to be retarded in their maturation in comparison to normal disomic ones, and the maternal age effect can be based on an accumulation of trisomy 21 oocytes...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2012.08.040
更新日期：2013-04-01 00:00:00
abstract：:For a dilation and evacuation (D&E) procedure, the cervix must be dilated sufficiently to allow passage of operative instruments and products of conception without injuring the uterus or cervical canal. Preoperative preparation of the cervix reduces the risk of cervical laceration and uterine perforation. The cervix m...
journal_title：Contraception
pub_type： 杂志文章,实务指引
doi：10.1016/j.contraception.2013.11.001
更新日期：2014-02-01 00:00:00
abstract：:The leucocytes adhering to intrauterine devices (IUDs) were predominantly mononuclear phagocytic cells (MPCs) and granulocytes. These cells released elastase and a plasminogen activator in the culture medium. The plasminogen activator was found to be immunologically identical to tissue activator, and the release patte...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(82)90083-x
更新日期：1982-08-01 00:00:00
abstract：:The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femoden...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(87)90069-2
更新日期：1987-04-01 00:00:00
abstract：:The continuation rate at the end of this five-year clinical study was 60% with no accidental pregnancy occurring throughout the five years. The post-removal conception rate in women desiring pregnancy was 92% at the end of two years. The majority of acceptors described the overall experience with the implants as favou...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(92)90139-k
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:The goal of this paper is to review the imaging methods required for localizing nonpalpable Implanontrade mark. METHOD:Different localization methods for nonpalpable Implanon rods are summarized, and clinical guidance is provided as to how best to localize such implants. RESULTS:In the great majority of cases...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/j.contraception.2005.10.009
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To determine the pharmacokinetics (PK) of drospirenone (DRSP), alone versus in combination with ethinyl estradiol (EE), after single and repeated administration. STUDY DESIGN:We conducted a single-centre, open-label, crossover, 2-treatment, 2-period, 2-sequence study in which non-micronized DRSP 4 mg or a co...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2019.10.005
更新日期：2020-02-01 00:00:00
abstract：:Surveys undertaken in the 1970s and 1980s suggested that amenorrhea was unacceptable to most women, especially in developing countries. More recent research suggests that increasing numbers of women in the developed world prefer to menstruate less often. In a questionnaire survey of 1001 women attending family-plannin...
journal_title：Contraception
pub_type： 杂志文章,多中心研究
doi：10.1016/s0010-7824(02)00474-2
更新日期：2003-01-01 00:00:00
abstract：:Saponins isolated from Sapindus mukorossi have potent spermicidal activity. Morphological changes in human ejaculated spermatozoa after exposure to these saponins were evaluated under Scanning Electron Microscope. The minimum effective concentration (0.05% in spot test) did not affect the surface topography after expo...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(89)90111-x
更新日期：1989-05-01 00:00:00
abstract：:A moderately effective oral progestogen contraceptive, R-2323 (13beta-ethyl-17alpha-ethynyl-17-hydroxy-gona-4,9,11-trien,3-one), was administered weekly in doses of 2.5 mg and 5 mg to 5 subjects each for 8 weeks. In 2 of the 10 treatment cycles of 2.5 mg and 4 of the 10 treatment cycles of 5 mg, progesterone levels i...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90071-7
更新日期：1974-08-01 00:00:00
abstract：:Barrier contraceptive trials and disease intervention studies often utilize coital diaries to measure sexual exposures: dates and frequency of intercourse, product use, additional or alternative contraceptive use, and menstrual bleeding. The validity of these self-reported data is a matter of debate, but if used, bett...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(01)00183-4
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVES:To compare pain levels and medication needs after placement of laminaria vs Dilapan-S, and after dilation and evacuation (D&E). STUDY DESIGN:We conducted a single-blinded randomized control trial of patients undergoing D&E at 15 0/7 to 23 6/7 weeks gestation, randomizing to cervical preparation with laminar...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/j.contraception.2020.11.014
更新日期：2020-12-04 00:00:00
abstract：:This was a dual-cohort study performed to determine if, by using methotrexate alone, abortions could be induced with fewer side effects, without sacrificing effectiveness and patient satisfaction. The subjects were 358 consecutive patients who requested elective medical termination of pregnancy at < 7 weeks gestation....
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/s0010-7824(98)00146-2
更新日期：1999-01-01 00:00:00
abstract：:The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...
journal_title：Contraception
pub_type： 杂志文章,评审
doi：10.1016/0010-7824(89)90012-7
更新日期：1989-01-01 00:00:00
abstract：:In a prospective, randomised dose-finding study involving 60 women scheduled for termination of 1st trimester pregnancy, 25 micrograms, 50 micrograms or 100 micrograms of a sulprostone gel with a constant injection volume of 2.5 ml were applied intracervically 6-8 hours before curettage. The gelatinising agent was Plu...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(85)90091-5
更新日期：1985-03-01 00:00:00
abstract：:To compare the effectiveness and safety of the Filshie Clip System and Hulka Clip System when applied via minilaparotomy and laparoscopy, we conducted 2 multicenter randomized controlled trials of 2126 women (878 in the minilaparotomy study and 1248 in the laparoscopy study) who received either the Filshie or Hulka Cl...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0010-7824(00)00166-9
更新日期：2000-10-01 00:00:00
abstract：:The use of multiple clips for the occlusion of the Fallopian tubes has been reported in interval laparoscopic sterilization, but the circumstances leading to the performance of the multiple-clip procedure and its effects on safety and efficacy have not been carefully studied. A data set from international multi-center...
journal_title：Contraception
pub_type： 临床试验,杂志文章
doi：10.1016/0010-7824(94)90058-2
更新日期：1994-11-01 00:00:00
abstract：:The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 x...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(02)00406-7
更新日期：2002-12-01 00:00:00
abstract：:Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mi...
journal_title：Contraception
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0010-7824(88)90102-3
更新日期：1988-09-01 00:00:00
abstract：:Injection of a polymer, styrene maleic anhydride (SMA), into the lumen of the vas deferens of rats, was observed to have effective and reversible contraception. The safety evaluation of the polymer, for 90 days, was carried out in Charles Foster male rats. There have been no significant changes in any of the toxicity ...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/s0010-7824(89)80010-1
更新日期：1989-02-01 00:00:00
abstract：:Differential precipitation of plasma proteins after equilibration of the plasma with tracer amounts of testosterone (T) was used to measure free and not-T-estradiol binding globulin (TeBG)-bound T in 20 women and 10 men. Tritiated T was the tracer used. Comparison of this method with the equilibration dialysis metho...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(74)90099-7
更新日期：1974-12-01 00:00:00
abstract：:Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm m...
journal_title：Contraception
pub_type： 杂志文章
doi：10.1016/0010-7824(88)90009-1
更新日期：1988-06-01 00:00:00
