Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens.


OBJECTIVE:The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). DESIGN:Blood samples were obtained from 62 women. RESULTS:When COCs were grouped by ethinyl estradiol (EE) dose, there was a significant positive mean slope for LH and FSH during the HFI for the 30- and 35 mcg-EE doses, whereas 20 showed a gradual nonsignificant slope. All E2 slopes were significant. P remained suppressed with all doses. CONCLUSION:A more rapid rebound of gonadotropin levels is found with higher doses of EE during the HFI. IMPLICATIONS:This study showed a more rapid rebound of pituitary hormone levels among women using higher-EE-dosage formulations, which was demonstrated by the statistically significant slope for mean LH and FSH from day 1 to day 7 of the HFI. The degree of suppression did not vary across progestin generations. It remains to be established whether women who experience side effects during their HFI may benefit from using a COC with a lower EE dose to minimize changes in endogenous pituitary hormone levels.






Cho M,Atrio J,Lim AH,Azen C,Stanczyk FZ




Has Abstract


2014-07-01 00:00:00














  • Observations of scanning electron microscopy detected abnormalities of non-lubricated latex condoms.

    abstract::To describe surface abnormalities found by scanning electron microscopy of non-lubricated latex condoms, thirty samples of 15 condoms were photographed at low (26-94x), medium (240-940x) and high (> 1000x) magnification. Each sample was initially scanned at low magnification to determine the presence and location of s...


    pub_type: 杂志文章


    authors: Rosenzweig BA,Even A,Budnick LE

    更新日期:1996-01-01 00:00:00

  • Buccal misoprostol as cervical preparation for second trimester pregnancy termination.

    abstract::The objective of the study was to assess the efficacy of cervical preparation with misoprostol or laminaria suction abortion up to 18 weeks gestation. The study was conducted among a consecutive case series of patients presenting for dilatation and evacuation at a single center. Cervical preparation was effected by ei...


    pub_type: 杂志文章


    authors: Todd CS,Soler M,Castleman L,Rogers MK,Blumenthal PD

    更新日期:2002-06-01 00:00:00

  • Treatment of pain during medical abortion.

    abstract::A structured literature review was undertaken to determine, in the context of early medical abortion, the proportion of women who require analgesia, the predictors of analgesia requirement and the most appropriate analgesia regimen. Studies from different centers show wide variations in analgesia use, but, overall, ar...


    pub_type: 杂志文章,评审


    authors: Penney G

    更新日期:2006-07-01 00:00:00

  • Availability of pharmacist prescription of contraception in rural areas of Oregon and New Mexico.

    abstract:OBJECTIVE:To determine the availability of pharmacist prescribing of hormonal contraception in rural areas of two states. STUDY DESIGN:Cross-sectional survey. RESULTS:Overall, 42% of pharmacies prescribed contraception (Oregon: 46% and New Mexico 19%). A similar proportion of rural pharmacies reported offering pharma...


    pub_type: 杂志文章


    authors: Rodriguez MI,Garg B,Williams SM,Souphanavong J,Schrote K,Darney BG

    更新日期:2020-03-01 00:00:00

  • Economic analysis of contraceptives for women.

    abstract:OBJECTIVE:To examine from the health care services payer perspective the economic consequences of contraceptives available to women in the United States. METHODS:A Markov model was constructed to compare effectiveness and costs among nine contraceptive methods (including 3-month injectable, oral contraceptives, intrau...


    pub_type: 杂志文章


    authors: Chiou CF,Trussell J,Reyes E,Knight K,Wallace J,Udani J,Oda K,Borenstein J

    更新日期:2003-07-01 00:00:00

  • "We have to what?": lessons learned about engaging support staff in an interprofessional intervention to implement MVA for management of spontaneous abortion.

    abstract:BACKGROUND:Including support staff in practice change initiatives is a promising strategy to successfully implement new reproductive health services. The Resident Training Initiative in Miscarriage Management (RTI-MM) is an intervention designed to facilitate implementation of manual vacuum aspiration (MVA) for managem...


    pub_type: 杂志文章


    authors: Darney BG,VanDerhei D,Weaver MR,Stevens NG,Prager SW

    更新日期:2013-08-01 00:00:00

  • Women's out-of-pocket expenditures and dispensing patterns for oral contraceptive pills between 1996 and 2006.

    abstract:BACKGROUND:Little is known about the out-of-pocket expenditures and dispensing patterns for oral contraceptive pills (OCPs), factors associated with these outcomes and whether they change over time. STUDY DESIGN:Observational cohort using 1996-2006 Medical Expenditure Panel Surveys. RESULTS:Women spent $16 out-of-poc...


    pub_type: 杂志文章


    authors: Liang SY,Grossman D,Phillips KA

    更新日期:2011-06-01 00:00:00

  • Progestin-only pill use over 6 months postpartum.

    abstract:OBJECTIVES:To determine progestin-only pill (POP) use at 3 and 6 months postpartum among women who chose POPs at the postpartum visit. STUDY DESIGN:Secondary data analysis of a prospective observational study with telephone interviews at 3 and 6 months postpartum to assess contraceptive use. RESULTS:Of 440 women who ...


    pub_type: 杂志文章


    authors: Uhm S,Garcia-Ruiz N,Creinin MD,Blanton A,Chen MJ

    更新日期:2020-10-01 00:00:00

  • Combined and national experience of postmenstrual IUD insertions of Nova-T and Copper-T in a randomized study.

    abstract::A randomized comparative study between Nova-T and Copper-T-200 was performed simultaneously in Denmark, Finland and Sweden. The results of 741 postmenstrual insertions with Nova-T and 780 with Copper-T are reported. The pregnancy rate of Nova-T was lower in every age and parity group. The pregnancy rate of Copper-T-20...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Luukkainen T,Nielsen NC,Nygren KG,Pyörälä T,Allonen H

    更新日期:1979-01-01 00:00:00

  • Competition between seminal and exogenous proteinase inhibitors for sites on murine epididymal sperm.

    abstract::Sixteen proteinase inhibitors were tested for their ability to compete with the natural seminal inhibitor for binding to the surface of murine epididymal sperm. The most effective competitors, 4-methylumbelliferyl-p-quanidinobenzoate (MUGB) and p-nitrophenyl-p-guanidinobenzoate (NPGB), are also effective inhibitors of...


    pub_type: 杂志文章


    authors: Aarons D,Robinson R,Richardson R,Poirier GR

    更新日期:1985-02-01 00:00:00

  • Effect of long-term progestin treatment on endometrial vasculature in normal cycling mice.

    abstract::The aim of this study was to develop a mouse model to investigate the effects of long-term progestin-only exposure on endometrial vascular structure. Normal cycling mice received Silastic implants containing either medroxyprogesterone acetate (MPA) or levonorgestrel (LNG) and were dissected after 1, 3 or 6 weeks. Endo...


    pub_type: 杂志文章


    authors: Girling JE,Heryanto B,Patel N,Rogers PA

    更新日期:2004-10-01 00:00:00

  • An initial pharmacokinetic study with a Metered Dose Transdermal Systemfor delivery of the progestogen Nestorone as a possible future contraceptive.

    abstract:BACKGROUND:Transdermal delivery of steroids is gaining popularity for contraception and hormone replacement therapy. This study aimed to test metered spray delivery of a precise dosage of Nestorone (NES) progestogen as a possible transdermal progestogen-only contraceptive. STUDY DESIGN:Six healthy postmenopausal volun...


    pub_type: 杂志文章


    authors: Fraser IS,Weisberg E,Kumar N,Kumar S,Humberstone AJ,McCrossin L,Shaw D,Tsong YY,Sitruk-Ware R

    更新日期:2007-12-01 00:00:00

  • Recent intrauterine device use and the risk of precancerous cervical lesions and cervical cancer.

    abstract:OBJECTIVE:Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by...


    pub_type: 杂志文章


    authors: Averbach S,Silverberg MJ,Leyden W,Smith-McCune K,Raine-Bennett T,Sawaya GF

    更新日期:2018-04-17 00:00:00

  • Four-year experience in a randomized study of the Gyne T 380 Slimline and the Standard Gyne T 380 intrauterine copper devices.

    abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sivin I,Diaz J,Alvarez F,Brache V,Diaz S,Pavez M,Stern J

    更新日期:1993-01-01 00:00:00

  • Determinants of oral contraceptive use in northern Italy.

    abstract::Socio-demographic characteristics, general lifestyle habits, reproductive and medical histories were compared of 328 women who had ever used oral contraceptives and 2306 never users from a case-control surveillance conducted in Northern Italy. Oral contraceptive use was positively and strongly related with the level o...


    pub_type: 杂志文章


    authors: La Vecchia C,Decarli A,Parazzini F,Gentile A,Negri E,Franceschi S

    更新日期:1986-08-01 00:00:00

  • A 1-year randomized study to evaluate the effects of a dose reduction in oral contraceptives on lipids and carbohydrate metabolism: 20 microg ethinyl estradiol combined with 100 microg levonorgestrel.

    abstract:OBJECTIVES:To evaluate the impact on lipid and carbohydrate variables of a combined one-third ethinyl estradiol (EE)/levonorgestrel (LNG) dose reduction in oral contraceptives. METHODS:In an open-label, randomized study, a dose-reduced oral contraceptive containing 20 microg EE and 100 microg LNG (20 EE/100 LNG) was c...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Skouby SO,Endrikat J,Düsterberg B,Schmidt W,Gerlinger C,Wessel J,Goldstein H,Jespersen J

    更新日期:2005-02-01 00:00:00

  • Cost-effectiveness of treatments for dysfunctional uterine bleeding in women who need contraception.

    abstract:OBJECTIVE:This study aims to compare the cost-effectiveness of oral contraceptives (OCs), the levonorgestrel-releasing intrauterine system (LNG-IUS) and surgical management in treating dysfunctional uterine bleeding (DUB) in women not desiring additional children. METHOD:A Markov model was constructed from the perspec...


    pub_type: 杂志文章,评审


    authors: Blumenthal PD,Trussell J,Singh RH,Guo A,Borenstein J,Dubois RW,Liu Z

    更新日期:2006-09-01 00:00:00

  • Use of intramuscular prostaglandin for failure of mid-trimester abortion by another method.

    abstract::Eight investigators, using a common protocol, studied the use of intramuscular (15S)-15-methyl prostaglandin F2 alpha to abort midtrimester pregnancies which had failed treatment by other methods in 398 cases. Results of treatment of 3 subgroups, defined by reason for primary treatment failure, are presented. The comb...


    pub_type: 杂志文章


    authors: Schwallie PC,Huang DC,Turner LF

    更新日期:1980-12-01 00:00:00

  • The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment.

    abstract::This communication is to report the effects of gossypol on the synthesis of chromosomal basic proteins in the spermiogenic cells. A double-labelling experiment has been performed. The control rats received 14C-arginine, whereas the gossypol-treated rats received a 3H-arginine injection. An equal volume of the tissues ...


    pub_type: 杂志文章


    authors: Teng CS,Fei RR

    更新日期:1988-03-01 00:00:00

  • Irregular bleeding, body mass index and coital frequency in Norplant contraceptive users.

    abstract::Seventy-five women with a mean age of 27.5 years who requested Norplant implants for contraception were studied over a five-year period. The patients kept daily diaries of their vaginal bleeding and coital frequency, and were seen at least every six months at which time their weight was measured. This study examines t...


    pub_type: 临床试验,杂志文章


    authors: Pasquale SA,Knuppel RA,Owens AG,Bachmann GA

    更新日期:1994-08-01 00:00:00

  • Associations between immediate postpartum long-acting reversible contraception and short interpregnancy intervals.

    abstract:OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...


    pub_type: 杂志文章


    authors: Wu M,Eisenberg R,Negassa A,Levi E

    更新日期:2020-12-01 00:00:00

  • Medroxyprogesterone acetate levels among Kenyan women using depot medroxyprogesterone acetate in the FEM-PrEP trial.

    abstract:OBJECTIVE:To describe medroxyprogesterone acetate (MPA) levels among Kenyan depot medroxyprogesterone acetate (DMPA) users in the FEM-PrEP HIV prevention trial, and to compare MPA levels between ARV for HIV prevention (treatment) and placebo groups. STUDY DESIGN:We measured MPA in previously collected plasma samples f...


    pub_type: 杂志文章,随机对照试验


    authors: Nanda K,Callahan R,Taylor D,Wang M,Agot K,Jenkins D,Van Damme L,Dorflinger L,FEM-PrEP Study Group.

    更新日期:2016-07-01 00:00:00

  • Safety of hormonal contraception and intrauterine devices among women with depressive and bipolar disorders: a systematic review.

    abstract:BACKGROUND:Women with depressive or bipolar disorders are at an increased risk for unintended pregnancy. OBJECTIVE:To examine the safety of hormonal contraception among women with depressive and bipolar disorders. METHODS:We searched for articles published through January 2016 on the safety of using any hormonal cont...


    pub_type: 杂志文章,评审


    authors: Pagano HP,Zapata LB,Berry-Bibee EN,Nanda K,Curtis KM

    更新日期:2016-12-01 00:00:00

  • Incidence of uterine rupture in second-trimester abortion with gemeprost alone compared to mifepristone and gemeprost.

    abstract:OBJECTIVES:To compare uterine rupture rates in women having a medical abortion receiving gemeprost alone to those receiving mifepristone plus gemeprost. STUDY DESIGN:We reviewed the records of women undergoing medical abortion at 13 0/7-23 6/7 weeks from January 2007 to December 2014 at a single center in Italy. Prior...


    pub_type: 杂志文章


    authors: Morra I,Ferrara C,Sglavo G,Sansone A,Saccone G,Perriera L,Di Carlo C

    更新日期:2019-03-01 00:00:00

  • Provision of medical abortion by midlevel healthcare providers in Kyrgyzstan: testing an intervention to expand safe abortion services to underserved rural and periurban areas.

    abstract:OBJECTIVE:To demonstrate the feasibility and safety of training midlevel healthcare providers (midwives and family nurses) to provide medical abortion and postabortion contraception in underserved areas in Kyrgyzstan. STUDY DESIGN:This was an implementation study at four referral facilities and 28 Felsher Obstetric Po...


    pub_type: 杂志文章


    authors: Johnson BR Jr,Maksutova E,Boobekova A,Davletova A,Kazakbaeva C,Kondrateva Y,Landoulsi S,Lazdane G,Monolbaev K,Seuc Jo AH

    更新日期:2018-02-01 00:00:00

  • Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE).

    abstract:OBJECTIVES:To compare the pharmacokinetic parameters and safety of the progestagen, Org 30659, (17alpha)-17-hydroxy-11-methylene-19-norpregna-4,15-dien-20-yn-3-one), and ethinyl estradiol (EE) in Caucasian and Japanese women after single and multiple doses. METHODS:This was an open-label parallel design of a single do...


    pub_type: 杂志文章


    authors: de Visser SJ,Uchida N,van Vliet-Daskalopoulou E,Fukazawa I,van Doorn MB,van den Heuvel MW,Machielsen CS,Uchida E,Cohen AF

    更新日期:2003-09-01 00:00:00

  • Anti-implantation activity of luteal phase mifepristone administration is not mimicked by prostaglandin synthesis inhibitor or prostaglandin analogue in the rhesus monkey.

    abstract::The use of mifepristone as an anti-implantation agent in the primate has been explored in the rhesus monkey with two specific aims: (i) to determine the contraceptive efficacy of very low-dose mifepristone administered on mated cycle days 16, 17, and 18; and (ii) to test the hypothesis that alteration in endometrial p...


    pub_type: 杂志文章


    authors: Nayak NR,Ghosh D,Lasley BL,Sengupta J

    更新日期:1997-02-01 00:00:00

  • Effect of prophylactic antibiotics on morbidity associated with IUD insertion: results of a pilot randomized controlled trial. IUD Study Group.

    abstract::The efficacy of administering an antibiotic prior to IUD insertion to reduce the risk of introducing an upper genital tract infection during the procedure has not yet been established. Two double-blind randomized studies conducted in Africa comparing a 200 mg prophylactic dose of doxycycline with a placebo did not con...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Walsh TL,Bernstein GS,Grimes DA,Frezieres R,Bernstein L,Coulson AH

    更新日期:1994-10-01 00:00:00

  • Abortion referral-making in the United States: findings and recommendations from the abortion referrals learning community.

    abstract::In recent years, reproductive health researchers and practitioners have increased their focus on abortion referrals as an overlooked component of access. March 2019 proposed changes to the regulation of publicly funded family planning services that severely restrict abortion referrals have heightened public attention....


    pub_type: 杂志文章,评审


    authors: Zurek M,O'Donnell J

    更新日期:2019-11-01 00:00:00

  • The incidence of gonorrhea in an abortion population.

    abstract::The incidence of gonorrhea was investigated in an abortion population. A total of 1021 women participated in this study. Three asymptomatic cases of gonorrhea were detected. None of these women had had gonorrhea before or had a previous abortion. No relation was found between the incidence of gonorrhea and age. The ab...


    pub_type: 杂志文章


    authors: Querido L,Haspels AA

    更新日期:1980-10-01 00:00:00