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Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens.

Abstract：

OBJECTIVE:The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). DESIGN:Blood samples were obtained from 62 women. RESULTS:When COCs were grouped by ethinyl estradiol (EE) dose, there was a significant positive mean slope for LH and FSH during the HFI for the 30- and 35 mcg-EE doses, whereas 20 showed a gradual nonsignificant slope. All E2 slopes were significant. P remained suppressed with all doses. CONCLUSION:A more rapid rebound of gonadotropin levels is found with higher doses of EE during the HFI. IMPLICATIONS:This study showed a more rapid rebound of pituitary hormone levels among women using higher-EE-dosage formulations, which was demonstrated by the statistically significant slope for mean LH and FSH from day 1 to day 7 of the HFI. The degree of suppression did not vary across progestin generations. It remains to be established whether women who experience side effects during their HFI may benefit from using a COC with a lower EE dose to minimize changes in endogenous pituitary hormone levels.

journal_name

Contraception

journal_title

Contraception

authors

Cho M,Atrio J,Lim AH,Azen C,Stanczyk FZ

doi

10.1016/j.contraception.2014.01.021

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

94-6

issue

1

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(14)00031-6

journal_volume

90

pub_type

临床试验,杂志文章

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