Pituitary and ovarian hormone activity during the 7-day hormone-free interval of various combined oral contraceptive regimens.

Abstract:

OBJECTIVE:The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). DESIGN:Blood samples were obtained from 62 women. RESULTS:When COCs were grouped by ethinyl estradiol (EE) dose, there was a significant positive mean slope for LH and FSH during the HFI for the 30- and 35 mcg-EE doses, whereas 20 showed a gradual nonsignificant slope. All E2 slopes were significant. P remained suppressed with all doses. CONCLUSION:A more rapid rebound of gonadotropin levels is found with higher doses of EE during the HFI. IMPLICATIONS:This study showed a more rapid rebound of pituitary hormone levels among women using higher-EE-dosage formulations, which was demonstrated by the statistically significant slope for mean LH and FSH from day 1 to day 7 of the HFI. The degree of suppression did not vary across progestin generations. It remains to be established whether women who experience side effects during their HFI may benefit from using a COC with a lower EE dose to minimize changes in endogenous pituitary hormone levels.

journal_name

Contraception

journal_title

Contraception

authors

Cho M,Atrio J,Lim AH,Azen C,Stanczyk FZ

doi

10.1016/j.contraception.2014.01.021

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

94-6

issue

1

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(14)00031-6

journal_volume

90

pub_type

临床试验,杂志文章
  • STS 557, a new orally active progestin with antiprogestational and contragestational properties in rabbits.

    abstract::STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90140-7

    authors: Oettel M,Kurischko A

    更新日期:1980-01-01 00:00:00

  • Postabortal contraception with norethisterone enanthate injections.

    abstract::Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90020-3

    authors: Lähteenmäki P,Toivonen J,Lähteenmäki PL

    更新日期:1983-06-01 00:00:00

  • A Bridge for postpartum women to Standard Days Method®: I. Developing the Bridge.

    abstract:BACKGROUND:A new fertility-awareness-based Bridge was developed for postpartum women starting with their first postpartum menses and until they are eligible to use the Standard Days Method®. This article describes the development of the Bridge and theoretical efficacy. STUDY DESIGN:Analysis of a preexisting data set c...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2011.11.009

    authors: Sinai I,Cachan J

    更新日期:2012-07-01 00:00:00

  • Intermittent GnRH antagonist plus progestin contraception conserving tonic ovarian estrogen secretion and reducing progestin exposure.

    abstract::The present study was designed to evaluate the effectiveness of a once-weekly regimen of GnRH antagonist followed by a progestin as a potential new contraceptive method. On menstrual cycle days 2, 9, 16, and 23 (onset of menses = Day 1) monkeys were divided into two groups: 1) those injected sc with 0.1 mg/kg Nal-Glu ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(09)91007-1

    authors: Danforth DR,Williams RF,Hsiu JG,Roh SI,Hahn D,McGuire JL,Hodgen GD

    更新日期:1990-06-01 00:00:00

  • Plasma lipoproteins and fatty acid composition after "minipill".

    abstract::A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(83)90038-0

    authors: Sassolas A,Lagarde M,Guichardant M,Quincy C,Dechavanne M

    更新日期:1983-10-01 00:00:00

  • Buccal misoprostol as cervical preparation for second trimester pregnancy termination.

    abstract::The objective of the study was to assess the efficacy of cervical preparation with misoprostol or laminaria suction abortion up to 18 weeks gestation. The study was conducted among a consecutive case series of patients presenting for dilatation and evacuation at a single center. Cervical preparation was effected by ei...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00306-2

    authors: Todd CS,Soler M,Castleman L,Rogers MK,Blumenthal PD

    更新日期:2002-06-01 00:00:00

  • Safety of intrauterine contraceptive device (copper T 200 B) in women with cardiac disease.

    abstract:BACKGROUND:Women with cardiac disease have need for effective long-lasting reversible contraception. Women with cardiac disease are at increased risk for bacterial endocarditis. There is limited research regarding the use of intrauterine contraceptive devices (IUD) in women with cardiac disease. STUDY DESIGN:In a pros...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2008.05.006

    authors: Suri V,Aggarwal N,Kaur R,Chaudhary N,Ray P,Grover A

    更新日期:2008-10-01 00:00:00

  • Studies on mechanism(s) of antifertility action of gossypol in rat and hamster.

    abstract::This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90066-8

    authors: Srivastava A,Gupta G,Setty BS

    更新日期:1989-03-01 00:00:00

  • Did increasing use of highly effective contraception contribute to declining abortions in Iowa?

    abstract:BACKGROUND:Between 2006 and 2008, Iowa increased access to family planning services through a Medicaid expansion and a privately funded initiative. During this same time, Iowa expanded access to abortion through telemedicine provision of medical abortion. Despite increased access to abortion services, abortions in Iowa...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.10.009

    authors: Biggs MA,Rocca CH,Brindis CD,Hirsch H,Grossman D

    更新日期:2015-02-01 00:00:00

  • Evaluation of one-hundred open-ended vasectomies.

    abstract::Open-ended vasectomy was performed on one-hundred men. Sixty-three of them showed up for follow-up six months later. Spontaneous recanalisation had occurred in two. Sperm granuloma without orchialgia was found in 14 out of 59 men (23.9%). Twenty-one out of the 63 thought their sex life had improved, while 40 thought i...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(86)90040-5

    authors: Temmerman M,Cammu H,Devroey P,Amy JJ

    更新日期:1986-06-01 00:00:00

  • Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill. A literature review.

    abstract::There is considerable variation in opinion about the importance of drug interactions between the combined oral contraceptive pill (COCP) and broad-spectrum antibiotics. Clinical practice varies widely, especially between doctors in Europe and those in the US. Rifampicin and griseofulvin induce hepatic enzymes and do a...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/s0010-7824(99)00009-8

    authors: Weaver K,Glasier A

    更新日期:1999-02-01 00:00:00

  • Pharmacodynamic effects of once-a-month combined injectable contraceptives.

    abstract::The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(94)90033-7

    authors: Sang GW

    更新日期:1994-04-01 00:00:00

  • Emergency contraception in Jordan: Assessing retail pharmacists' awareness, opinions, and perceptions of need.

    abstract:OBJECTIVES:Jordan has a robust contraceptive method mix in both the public and private sectors and oral contraceptive pills and the copper-T intrauterine device are widely available. However, Jordan remains one of only a few countries in the world without a registered dedicated product for emergency contraception (EC)....

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.10.002

    authors: El-Mowafi IM,Foster AM

    更新日期:2020-04-01 00:00:00

  • Corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy in simulated uterine fluid.

    abstract::Chemical immersion tests, electrochemical methods and atomic absorption spectrometry were employed to investigate the corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy (SMA) in simulated uterine fluid. The effect of pH on corrosion rate and corrosion potential was also investigated. The results indicated th...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2005.04.006

    authors: Chen B,Liang C,Fu D,Ren D

    更新日期:2005-09-01 00:00:00

  • A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy.

    abstract::This was a double-blind randomized control study to evaluate the efficacy of cervical priming by nitric oxide donor before second-trimester induced abortion. One-hundred healthy women with a singleton pregnancy between 14 and 20 weeks of gestation were randomized into either 40 mg isosorbide mononitrate or placebo, gi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(03)00170-7

    authors: Li CF,Chan CW,Ho PC

    更新日期:2003-10-01 00:00:00

  • Management and localization strategies for the nonpalpable Implanon rod.

    abstract:PURPOSE:The goal of this paper is to review the imaging methods required for localizing nonpalpable Implanontrade mark. METHOD:Different localization methods for nonpalpable Implanon rods are summarized, and clinical guidance is provided as to how best to localize such implants. RESULTS:In the great majority of cases...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2005.10.009

    authors: Shulman LP,Gabriel H

    更新日期:2006-04-01 00:00:00

  • Effect of obesity on the effectiveness of hormonal contraceptives: an individual participant data meta-analysis.

    abstract:OBJECTIVE:The objective of this investigation was to assess the potential effect of obesity on the effectiveness of hormonal contraceptives (HCs). STUDY DESIGN:A meta-analysis was conducted using individual participant data directly from the Phase 3 clinical trials of combination oral contraceptives (COCs) rather than...

    journal_title:Contraception

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.contraception.2015.07.016

    authors: Yamazaki M,Dwyer K,Sobhan M,Davis D,Kim MJ,Soule L,Willett G,Yu C

    更新日期:2015-11-01 00:00:00

  • Effects of quinestrol on hepatic function in the rat.

    abstract::Hepatic function in female rats given 200 microgram of quinestrol every 15 days for up to 210 days was studied. Prolonged treatment with quinestrol affected liver weight, serum cholestrol levels, biliar flux, and bromosulphthalein test, but these parameters tended toward control levels after 30 days of treatment. Quin...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(78)80021-3

    authors: Gioia IA,Lencioni LJ,Koch OR

    更新日期:1978-09-01 00:00:00

  • Effectiveness of the Yuzpe regimen of emergency contraception by cycle day of intercourse: implications for mechanism of action.

    abstract:OBJECTIVE:The purpose of this study was to provide evidence about the mechanism of action of the Yuzpe method of emergency contraception by examining effectiveness by cycle day of intercourse relative to ovulation. METHODS:Through a literature search, we identified eight studies that present the number of women treate...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00486-9

    authors: Trussell J,Ellertson C,Dorflinger L

    更新日期:2003-03-01 00:00:00

  • Uterine factors and risk of pregnancy in IUD users: a nested case-control study.

    abstract::Scarce data are available on the relation between the effectiveness of intrauterine device (IUD) and the gynecologic features of a woman. A nested case-control study was conducted to determine whether the uterine position and hysterometry affect the pregnancy rate of copper IUD. Seventy-one cases (pregnant women with ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00480-8

    authors: Avecilla-Palau A,Moreno V

    更新日期:2003-03-01 00:00:00

  • Assessment of contraceptive use in Puerto Rico during the 2016 Zika virus outbreak.

    abstract:OBJECTIVES:The objectives of this analysis were to 1) estimate prevalence of contraceptive use among women at risk for unintended pregnancy and 2) identify correlates of contraceptive use among women with ongoing or potential need for contraceptive services in Puerto Rico during the 2016 Zika virus (ZIKV) outbreak. ST...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.03.001

    authors: Ellington SR,Rodriguez RS,Goldberg H,Bertolli J,Simeone RM,Mercado AS,Pazol K,Jamieson DJ,Honein MA,Swartzendruber A,Miles T,Cordero JF,Shapiro-Mendoza CK

    更新日期:2020-06-01 00:00:00

  • Is there an association between the use of oral contraception and depressive symptoms in young Australian women?

    abstract:PURPOSE:The purpose of this study was to explore the relationship between oral contraceptive pill (OCP) use and the experience of depressive symptoms among a representative sample of young Australian women. METHODS:The study sample comes from the Australian Longitudinal Study on Women's Health. Analysis was confined t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2006.08.002

    authors: Duke JM,Sibbritt DW,Young AF

    更新日期:2007-01-01 00:00:00

  • Transdermal delivery of steroids.

    abstract::The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/0010-7824(89)90012-7

    authors: Sitruk-Ware R

    更新日期:1989-01-01 00:00:00

  • Bleeding pattern, outcome of accidental pregnancies and levonorgestrel plasma levels associated with method failure in Norplant implants users.

    abstract::The aim of this study was to characterize the bleeding pattern, the outcome of pregnancies and the levonorgestrel plasma levels associated with method failures in Norplant implants users. Nineteen pregnancies are reported in 458 woman and 21,589 woman-months observed during the first eight years of Norplant use. Pregn...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(86)90096-x

    authors: Díaz S,Pavez M,Herreros C,Johansson ED,Croxatto HB

    更新日期:1986-04-01 00:00:00

  • Trends in nonresident abortion rates in New York City from 2005 to 2015: a time series analysis.

    abstract:OBJECTIVES:To examine trends and utilization patterns of NYC abortion services by nonresidents since growing abortion restrictions across many states could drive women to seek care in less restrictive jurisdictions including NYC. STUDY DESIGN:We used data from Induced Termination of Pregnancy certificates filed with t...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.05.008

    authors: Johansson EW,Argov EL,Langston A,Yager A,Searing H,Liu SY

    更新日期:2019-09-01 00:00:00

  • Comprehensive analysis of the use of pre-procedure ultrasound for first- and second-trimester abortion.

    abstract:BACKGROUND:The use of ultrasound (US) is common in some settings before an abortion procedure. However, its positive effect on the safety or efficacy (ability to complete abortion) of the procedure has not been established. Our aim was to determine whether the use of pre-procedure US improves safety and/or efficacy of ...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2010.06.014

    authors: Kulier R,Kapp N

    更新日期:2011-01-01 00:00:00

  • Estimating the lifetime incidence of induced abortion and understanding abortion practices in a Northeastern Tanzania community through a household survey.

    abstract:OBJECTIVES:All Tanzanian abortion estimates rely on health facility data that do not take into account completely the incidence of abortion. This papers aims to estimate the lifetime incidence of induced abortion in Arusha, Tanzania via direct and double list-experiment methods using community data and evaluate outcome...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.10.013

    authors: Elewonibi B,Amour C,Gleason S,Msuya S,Canning D,Shah I

    更新日期:2021-02-01 00:00:00

  • Adherence to dual-method contraceptive use.

    abstract:BACKGROUND:Patient characteristics associated with adherence to dual-method contraceptive use are not known. STUDY DESIGN:Project PROTECT was a 24-month-long randomized trial designed to promote the use of dual methods of contraception using an individualized computer-based intervention or enhanced standard care couns...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2011.01.023

    authors: Peipert JF,Zhao Q,Meints L,Peipert BJ,Redding CA,Allsworth JE

    更新日期:2011-09-01 00:00:00

  • Menstrual induction with mifepristone and misoprostol.

    abstract::Menstrual induction refers to early uterine evacuation without laboratory confirmation of pregnancy in women with delayed menses. Mechanical aspiration is the method used in many countries but, as suggested by a pilot study, mifepristone followed by a prostaglandin analogue could also be effective. We launched the pre...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.contraception.2003.09.009

    authors: Xiao B,von Hertzen H,Zhao H,Piaggio G

    更新日期:2003-12-01 00:00:00

  • Economic analysis of contraceptives for women.

    abstract:OBJECTIVE:To examine from the health care services payer perspective the economic consequences of contraceptives available to women in the United States. METHODS:A Markov model was constructed to compare effectiveness and costs among nine contraceptive methods (including 3-month injectable, oral contraceptives, intrau...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(03)00078-7

    authors: Chiou CF,Trussell J,Reyes E,Knight K,Wallace J,Udani J,Oda K,Borenstein J

    更新日期:2003-07-01 00:00:00