Abstract:
OBJECTIVE:The objective was to investigate changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) during the hormone-free interval (HFI) of 6 combined oral contraceptives (COCs). DESIGN:Blood samples were obtained from 62 women. RESULTS:When COCs were grouped by ethinyl estradiol (EE) dose, there was a significant positive mean slope for LH and FSH during the HFI for the 30- and 35 mcg-EE doses, whereas 20 showed a gradual nonsignificant slope. All E2 slopes were significant. P remained suppressed with all doses. CONCLUSION:A more rapid rebound of gonadotropin levels is found with higher doses of EE during the HFI. IMPLICATIONS:This study showed a more rapid rebound of pituitary hormone levels among women using higher-EE-dosage formulations, which was demonstrated by the statistically significant slope for mean LH and FSH from day 1 to day 7 of the HFI. The degree of suppression did not vary across progestin generations. It remains to be established whether women who experience side effects during their HFI may benefit from using a COC with a lower EE dose to minimize changes in endogenous pituitary hormone levels.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Cho M,Atrio J,Lim AH,Azen C,Stanczyk FZdoi
10.1016/j.contraception.2014.01.021subject
Has Abstractpub_date
2014-07-01 00:00:00pages
94-6issue
1eissn
0010-7824issn
1879-0518pii
S0010-7824(14)00031-6journal_volume
90pub_type
临床试验,杂志文章相关文献
CONTRACEPTION文献大全abstract::STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone ad...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90140-7
更新日期:1980-01-01 00:00:00
abstract::Intramuscular injection of 200 mg norethisterone enanthate (NET-EN) was given to five women on the day of first trimester abortion. The injection was repeated twice at eight-week intervals, and thereafter at twelve-week intervals for one year. Plasma samples were collected for FSH, LH/hCG, estradiol, progesterone and ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90020-3
更新日期:1983-06-01 00:00:00
abstract:BACKGROUND:A new fertility-awareness-based Bridge was developed for postpartum women starting with their first postpartum menses and until they are eligible to use the Standard Days Method®. This article describes the development of the Bridge and theoretical efficacy. STUDY DESIGN:Analysis of a preexisting data set c...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2011.11.009
更新日期:2012-07-01 00:00:00
abstract::The present study was designed to evaluate the effectiveness of a once-weekly regimen of GnRH antagonist followed by a progestin as a potential new contraceptive method. On menstrual cycle days 2, 9, 16, and 23 (onset of menses = Day 1) monkeys were divided into two groups: 1) those injected sc with 0.1 mg/kg Nal-Glu ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(09)91007-1
更新日期:1990-06-01 00:00:00
abstract::A study of the effect of a low-dose oral contraceptive, Adepal (ethinyl estradiol and levonorgestrel, 30 and 150 micrograms on the 5th to 12th, 40 and 200 micrograms on the 13th to 28th, respectively) on the blood lipids, lipoproteins and fatty acid composition has been conducted on 13 young women before and after six...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(83)90038-0
更新日期:1983-10-01 00:00:00
abstract::The objective of the study was to assess the efficacy of cervical preparation with misoprostol or laminaria suction abortion up to 18 weeks gestation. The study was conducted among a consecutive case series of patients presenting for dilatation and evacuation at a single center. Cervical preparation was effected by ei...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00306-2
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Women with cardiac disease have need for effective long-lasting reversible contraception. Women with cardiac disease are at increased risk for bacterial endocarditis. There is limited research regarding the use of intrauterine contraceptive devices (IUD) in women with cardiac disease. STUDY DESIGN:In a pros...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2008.05.006
更新日期:2008-10-01 00:00:00
abstract::This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(89)90066-8
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Between 2006 and 2008, Iowa increased access to family planning services through a Medicaid expansion and a privately funded initiative. During this same time, Iowa expanded access to abortion through telemedicine provision of medical abortion. Despite increased access to abortion services, abortions in Iowa...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.10.009
更新日期:2015-02-01 00:00:00
abstract::Open-ended vasectomy was performed on one-hundred men. Sixty-three of them showed up for follow-up six months later. Spontaneous recanalisation had occurred in two. Sperm granuloma without orchialgia was found in 14 out of 59 men (23.9%). Twenty-one out of the 63 thought their sex life had improved, while 40 thought i...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90040-5
更新日期:1986-06-01 00:00:00
abstract::There is considerable variation in opinion about the importance of drug interactions between the combined oral contraceptive pill (COCP) and broad-spectrum antibiotics. Clinical practice varies widely, especially between doctors in Europe and those in the US. Rifampicin and griseofulvin induce hepatic enzymes and do a...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/s0010-7824(99)00009-8
更新日期:1999-02-01 00:00:00
abstract::The pharmacology and clinical assessment of existing first generation once-a-month combined injectable contraceptives, mainly Deladroxate and Chinese Injectable No. 1, are reviewed. Although these two types of monthly injectables have been used in some million women in China and Latin America, Deladroxate needs indept...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(94)90033-7
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVES:Jordan has a robust contraceptive method mix in both the public and private sectors and oral contraceptive pills and the copper-T intrauterine device are widely available. However, Jordan remains one of only a few countries in the world without a registered dedicated product for emergency contraception (EC)....
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.10.002
更新日期:2020-04-01 00:00:00
abstract::Chemical immersion tests, electrochemical methods and atomic absorption spectrometry were employed to investigate the corrosion behavior of Cu and the Cu-Zn-Al shape memory alloy (SMA) in simulated uterine fluid. The effect of pH on corrosion rate and corrosion potential was also investigated. The results indicated th...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2005.04.006
更新日期:2005-09-01 00:00:00
abstract::This was a double-blind randomized control study to evaluate the efficacy of cervical priming by nitric oxide donor before second-trimester induced abortion. One-hundred healthy women with a singleton pregnancy between 14 and 20 weeks of gestation were randomized into either 40 mg isosorbide mononitrate or placebo, gi...
journal_title:Contraception
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0010-7824(03)00170-7
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:The goal of this paper is to review the imaging methods required for localizing nonpalpable Implanontrade mark. METHOD:Different localization methods for nonpalpable Implanon rods are summarized, and clinical guidance is provided as to how best to localize such implants. RESULTS:In the great majority of cases...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2005.10.009
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:The objective of this investigation was to assess the potential effect of obesity on the effectiveness of hormonal contraceptives (HCs). STUDY DESIGN:A meta-analysis was conducted using individual participant data directly from the Phase 3 clinical trials of combination oral contraceptives (COCs) rather than...
journal_title:Contraception
pub_type: 杂志文章,meta分析
doi:10.1016/j.contraception.2015.07.016
更新日期:2015-11-01 00:00:00
abstract::Hepatic function in female rats given 200 microgram of quinestrol every 15 days for up to 210 days was studied. Prolonged treatment with quinestrol affected liver weight, serum cholestrol levels, biliar flux, and bromosulphthalein test, but these parameters tended toward control levels after 30 days of treatment. Quin...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(78)80021-3
更新日期:1978-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to provide evidence about the mechanism of action of the Yuzpe method of emergency contraception by examining effectiveness by cycle day of intercourse relative to ovulation. METHODS:Through a literature search, we identified eight studies that present the number of women treate...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00486-9
更新日期:2003-03-01 00:00:00
abstract::Scarce data are available on the relation between the effectiveness of intrauterine device (IUD) and the gynecologic features of a woman. A nested case-control study was conducted to determine whether the uterine position and hysterometry affect the pregnancy rate of copper IUD. Seventy-one cases (pregnant women with ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00480-8
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:The objectives of this analysis were to 1) estimate prevalence of contraceptive use among women at risk for unintended pregnancy and 2) identify correlates of contraceptive use among women with ongoing or potential need for contraceptive services in Puerto Rico during the 2016 Zika virus (ZIKV) outbreak. ST...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.03.001
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to explore the relationship between oral contraceptive pill (OCP) use and the experience of depressive symptoms among a representative sample of young Australian women. METHODS:The study sample comes from the Australian Longitudinal Study on Women's Health. Analysis was confined t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2006.08.002
更新日期:2007-01-01 00:00:00
abstract::The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/0010-7824(89)90012-7
更新日期:1989-01-01 00:00:00
abstract::The aim of this study was to characterize the bleeding pattern, the outcome of pregnancies and the levonorgestrel plasma levels associated with method failures in Norplant implants users. Nineteen pregnancies are reported in 458 woman and 21,589 woman-months observed during the first eight years of Norplant use. Pregn...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90096-x
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVES:To examine trends and utilization patterns of NYC abortion services by nonresidents since growing abortion restrictions across many states could drive women to seek care in less restrictive jurisdictions including NYC. STUDY DESIGN:We used data from Induced Termination of Pregnancy certificates filed with t...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.05.008
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The use of ultrasound (US) is common in some settings before an abortion procedure. However, its positive effect on the safety or efficacy (ability to complete abortion) of the procedure has not been established. Our aim was to determine whether the use of pre-procedure US improves safety and/or efficacy of ...
journal_title:Contraception
pub_type: 杂志文章,评审
doi:10.1016/j.contraception.2010.06.014
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:All Tanzanian abortion estimates rely on health facility data that do not take into account completely the incidence of abortion. This papers aims to estimate the lifetime incidence of induced abortion in Arusha, Tanzania via direct and double list-experiment methods using community data and evaluate outcome...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.10.013
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Patient characteristics associated with adherence to dual-method contraceptive use are not known. STUDY DESIGN:Project PROTECT was a 24-month-long randomized trial designed to promote the use of dual methods of contraception using an individualized computer-based intervention or enhanced standard care couns...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2011.01.023
更新日期:2011-09-01 00:00:00
abstract::Menstrual induction refers to early uterine evacuation without laboratory confirmation of pregnancy in women with delayed menses. Mechanical aspiration is the method used in many countries but, as suggested by a pilot study, mifepristone followed by a prostaglandin analogue could also be effective. We launched the pre...
journal_title:Contraception
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.contraception.2003.09.009
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:To examine from the health care services payer perspective the economic consequences of contraceptives available to women in the United States. METHODS:A Markov model was constructed to compare effectiveness and costs among nine contraceptive methods (including 3-month injectable, oral contraceptives, intrau...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(03)00078-7
更新日期:2003-07-01 00:00:00