Abstract:
BACKGROUND:A previous investigation showed that among 120 healthy women treated with a single oral dose of gestrinone for emergency contraception (EC), there was only one pregnancy. The effect of a single oral dose of gestrinone given for EC on ovarian function and endometrial development was studied. STUDY DESIGN:Healthy fertile women were randomly assigned to Group A (n=8) or Group B (n=7). Gestrinone 5 mg was orally administered to each woman before (Group A) or after (Group B) ovulation. The day of ovulation was determined by transvaginal ultrasound and by urinary luteinizing hormone (LH) measured by enzyme immunoassay (One Step LH Ovulation Test). An endometrial biopsy was performed during implantation. Endometrial maturation and expression of markers of endometrial receptivity were analyzed. The tested markers were integrins alpha(1)beta(1), alpha(4)beta(1) and beta(3). Serum estradiol (E(2)) and progesterone (P) levels in serum were determined by radioimmunoassay, and estradiol receptors and progesterone receptors (PRs) in the endometrium were assessed by immunohistochemistry. RESULTS:Gestrinone administered during the periovulatory period did not affect follicular development, ovulation, menstrual cycle length and E(2) and P levels but decreased the expression of PR in the endometrium. Integrin alpha(4)beta(1) tended to increase after treatment with gestrinone without reaching statistical significance. CONCLUSION:The mode of action of gestrinone used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibition of ovulation.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Gao X,Wu E,Chen Gdoi
10.1016/j.contraception.2007.05.089subject
Has Abstractpub_date
2007-09-01 00:00:00pages
221-7issue
3eissn
0010-7824issn
1879-0518pii
S0010-7824(07)00309-5journal_volume
76pub_type
临床试验,杂志文章,随机对照试验相关文献
CONTRACEPTION文献大全abstract:BACKGROUND:Between 2006 and 2008, Iowa increased access to family planning services through a Medicaid expansion and a privately funded initiative. During this same time, Iowa expanded access to abortion through telemedicine provision of medical abortion. Despite increased access to abortion services, abortions in Iowa...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2014.10.009
更新日期:2015-02-01 00:00:00
abstract::Condoms from five manufacturers were subjected to controlled exposures of heat, humidity, and air and to different natural environments in five countries. Under aerobic conditions (condoms in permeable packages or unpackaged), stress properties declined. The relationship between rate of decline as a function of temper...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(96)00041-8
更新日期:1996-04-01 00:00:00
abstract::Seventy-five women with a mean age of 27.5 years who requested Norplant implants for contraception were studied over a five-year period. The patients kept daily diaries of their vaginal bleeding and coital frequency, and were seen at least every six months at which time their weight was measured. This study examines t...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(94)90047-7
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Women with cardiac disease have need for effective long-lasting reversible contraception. Women with cardiac disease are at increased risk for bacterial endocarditis. There is limited research regarding the use of intrauterine contraceptive devices (IUD) in women with cardiac disease. STUDY DESIGN:In a pros...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/j.contraception.2008.05.006
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.01.009
更新日期:2020-05-01 00:00:00
abstract::LHRH and three potent antagonistic analogs: z-[Gln1, des-His2,D-Pse6,des-Gly10]-LHRH ethylamide, where D-Pse = threo-D-phenylserine; z-[Gln1,des-His2,D-Phe6,des-Gly10]-LHRH ethylamide; and Boc-[Ser(Bzl)1,des-His2,D-Trp6]-LHRH; were studied for their effects on blood pressure and heart rate in chronically catheterized ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(82)90096-8
更新日期:1982-04-01 00:00:00
abstract::The effect of continuous release of microquantities of cyproterone acetate from subcutaneously implanted silastic capsules on the fertility of surgically manipulated seminal vesicles of rat has been studied. The experimental animals showed infertility for 3 weeks, as a consequence of removal of seminal plasma, followi...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90130-4
更新日期:1980-02-01 00:00:00
abstract::The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured. These properties govern the critical functions of spreading and retention of these gels over the vaginal surfaces. Measurements made on Conceptrol, KY Plus, Gynol II,...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(00)00184-0
更新日期:2000-12-01 00:00:00
abstract::A morphometric study was undertaken to quantitate vessel numbers in uterine biopsies from a control group of patients, patients with dysfunctional uterine bleeding and patients taking low dose norethisterone or levonorgestrel. Vessels were counted at the endometrial/myometrial junction and in the functional endometriu...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(86)80016-6
更新日期:1986-12-01 00:00:00
abstract::Patients taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine together with their oral contraceptive steroid may suffer contraceptive failure because of the enzyme-inducing properties of these anticonvulsants. We have examined, in six women, the effect of sodium valproate, an effective broad spec...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(86)90028-4
更新日期:1986-01-01 00:00:00
abstract::The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 x...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00406-7
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:This study aims to clarify the associations between mobile phone ownership use on family planning outcomes. Secondary analysis of DHS data finds that in certain contexts, mobile phone ownership may be related to increased FP uptake. STUDY DESIGN:Using recent data for women 15-49 from the Demographic and Hea...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2019.10.004
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:As part of a strategy to revitalize postpartum family planning services, Government of India revised its policy in 2013 to permit trained nurses and midwives to insert postpartum intrauterine contraceptive devices (PPIUCDs). This study compares two key outcomes of PPIUCD insertions--expulsion and infection--f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2015.12.012
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:The objectives were to assess acceptors' attitudes toward Sayana® Press as a method and toward the mechanism of community-based distribution by medical and nursing (M/N) students, known locally as "DBCs," in Kinshasa, Democratic Republic of the Congo, and to evaluate the experience of these DBCs. STUDY DESI...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2017.05.014
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:It can prove challenging to create social marketing materials aimed at a specific subsection of the population, especially when the topic is relatively new and possibly misunderstood. Therefore, the objective of this study was to assess adolescent knowledge of and attitudes towards emergency contraception (E...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2009.08.005
更新日期:2010-02-01 00:00:00
abstract::9-Deoxo-16, 16-dimethyl-9-methylene-PGE2 is a new prostaglandin analogue which is stable in suppository form. Estimates of potential for gastrointestinal side effects in monkey in vivo indicated that the frequency of diarrhea was low with retention of uterine stimulating potency. In the present study the effect of the...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(80)90059-1
更新日期:1980-08-01 00:00:00
abstract:OBJECTIVE:To evaluate pregnancy complication rates and related charges in users of 84/7, 21/7 and 24/4 combined oral contraceptives (COCs). STUDY DESIGN:Data were obtained from the i3 InVision Data Mart™ retrospective claims database. Subjects were aged 15-40 years, first prescribed a COC between 1/1/2006 and 4/1/2011...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2013.12.006
更新日期:2014-05-01 00:00:00
abstract::This paper presents a secondary analysis of 3419 Norplant users from 11 countries throughout Asia, Africa and Latin America. The main objective was to identify the menstrual problems associated with a high risk of early discontinuation of Norplant use. Eligible participants were divided into two groups: those who cont...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(03)00040-4
更新日期:2003-05-01 00:00:00
abstract::An estimate of the menstrual blood loss (MBL) in 29 women using the Cu-7 and in 33 women using the ML-250 IUDs was carried out. None of the women who took part in the study used hormonal contraceptives or IUDs for six months previous to the study. Before the insertion of the IUD, the MBL of each woman was measured for...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(82)90146-9
更新日期:1982-11-01 00:00:00
abstract::Two-hundred-eight women attending family planning clinics in New York City who received the Norplant contraceptive system during the first sixteen months of Norplant implants insertions were evaluated. Within this clinic population, Norplant implants were a popular contraceptive choice and were removed from 64 of the ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(94)90096-5
更新日期:1994-06-01 00:00:00
abstract::Zona-free hamster oocytes were used to evaluate the entry of human spermatozoa into the oocytes. Suspensions of spermatozoa, free of seminal plasma, were preincubated for varying periods in a modified Tyrode's solution under mineral oil. Zona-free hamster oocytes were prepared and added to the sperm suspension for f...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(78)90064-1
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:The objectives of this analysis were to 1) estimate prevalence of contraceptive use among women at risk for unintended pregnancy and 2) identify correlates of contraceptive use among women with ongoing or potential need for contraceptive services in Puerto Rico during the 2016 Zika virus (ZIKV) outbreak. ST...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2020.03.001
更新日期:2020-06-01 00:00:00
abstract::The study was conducted to profile women seeking abortions at the National University Hospital, with particular interest in the trend of teenage pregnancies with the aim of identifying risk factors for late presentation for abortions. All patients who underwent an abortion at our center from January 1, 1996 to Decembe...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/s0010-7824(02)00317-7
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:This study was conducted to evaluate the effect of levonorgestrel-releasing intrauterine devices (LNG-IUDs) on menorrhagia in patients receiving anticoagulant therapy after cardiac valve replacement. STUDY DESIGN:Forty women with menorrhagia who underwent cardiac valve replacement and were taking anticoagul...
journal_title:Contraception
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.contraception.2009.02.007
更新日期:2009-08-01 00:00:00
abstract::The continuation rate at the end of this five-year clinical study was 60% with no accidental pregnancy occurring throughout the five years. The post-removal conception rate in women desiring pregnancy was 92% at the end of two years. The majority of acceptors described the overall experience with the implants as favou...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(92)90139-k
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Medroxyprogesterone acetate (MPA) and norethisterone (NET) and its derivatives are widely used in female reproductive therapy, but little is known about their mechanisms of action via steroid receptors in the female genital tract. MPA used as a contraceptive has been implicated in effects on local immune fun...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/j.contraception.2011.06.006
更新日期:2011-10-01 00:00:00
abstract::Ethylene-vinyl acetate (EVA) polymeric contraceptive implants (Implanon) containing 3-keto-desogestrel have been prepared aiming at an in vitro initial release rate of 60 micrograms 3-keto-desogestrel/day. These implants are designed to have an intended life-time of 2 years. During a 3-year period, the release of thes...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(93)90093-m
更新日期:1993-02-01 00:00:00
abstract::The Copper T-220C intrauterine device was modified for use in early postpartum insertions. Biodegradable extensions consisting of No. 2 chromic suture were added to the horizontal arms of the device to enhance retention. This new device, Delta-T IUD, was inserted in 100 patients within 55 hours of the delivery of the ...
journal_title:Contraception
pub_type: 临床试验,杂志文章
doi:10.1016/0010-7824(83)90013-6
更新日期:1983-08-01 00:00:00
abstract::To test the contraceptive efficacy of norethindrone (NET), the effect of NET on peripheral plasma levels of progesterone and estradiol after ovulation was investigated, since low levels of ovarian steroids might affect the postovulatory endometrium and thereby impair normal blastocyst implantation. Two studies were ...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(72)90011-x
更新日期:1972-06-01 00:00:00
abstract::In pharmacological test models providing repeated daily administrations of steroid hormones, differing time courses of the drug level depending upon the pharmacokinetics can be observed often. The present study should make a contribution to the question whether the time course of the drug level can have an influence o...
journal_title:Contraception
pub_type: 杂志文章
doi:10.1016/0010-7824(84)90068-4
更新日期:1984-04-01 00:00:00