Use of cauda epididymis extract as immunocontraceptive.

Abstract:

:The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 x 10(9) sperm/mL, while primipara rats received injections of CEE containing 3 x 10(6) sperm/mL up to three times. Animals were tested for the presence and concentration of anti-CEE antibody by enzyme-linked immunosorbent assay (ELISA) and monitored for pregnancy following natural insemination. Results revealed that 38 (92.6%) of the 41 rats were positive for anti-CEE antibodies, regardless of animal type or immunization procedure. However, there was no relation between pregnancy rates and concentration of anti-CEE antibody in rats immunized with CEE. These results indicate that immune response against CEE may not play a major role in contraception in rats.

journal_name

Contraception

journal_title

Contraception

authors

Risvanli A,Aydin M,Kaygusuzoglu E,Bulut H,Apaydin AM,Timurkan H

doi

10.1016/s0010-7824(02)00406-7

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

459-62

issue

6

eissn

0010-7824

issn

1879-0518

pii

S0010782402004067

journal_volume

66

pub_type

杂志文章
  • A study of the relationship between tensile testing of condoms and breakage in use.

    abstract::The ability of the condom wall to maintain its integrity throughout sexual intercourse is critical to its role in halting the spread of major sexually transmissible pathogens including the human immunodeficiency virus. There are three principal in vitro performance tests applied to condoms: a test for freedom from hol...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90045-h

    authors: Gerofi J,Shelley G,Donovan B

    更新日期:1991-02-01 00:00:00

  • Interest in a pericoital pill among women in family planning and abortion clinics.

    abstract:BACKGROUND:The purpose of this study was to determine whether women might be interested in repeated use of a pericoital pill, a pill taken around the time of each act of intercourse. STUDY DESIGN:We surveyed women from abortion (n=635) and family planning (n=981) clinics regarding their interest in using a pericoital ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2013.01.004

    authors: Foster DG,Biggs MA,Grossman D,Schwarz EB

    更新日期:2013-07-01 00:00:00

  • Implications of dispensing self-administered hormonal contraceptives in a 1-year supply: a California case study.

    abstract::On September 23, 2016, California became the sixth state to pass legislation requiring health plans and insurers to cover a 12-month supply of FDA-approved self-administered hormonal contraceptives such as contraceptive pills, patches and vaginal rings. This legislation is estimated to result in 38% of current contrac...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.12.008

    authors: McMenamin SB,Charles SA,Tabatabaeepour N,Shigekawa E,Corbett G

    更新日期:2017-05-01 00:00:00

  • Prazosin, an adrenergic blocking agent inadequate as male contraceptive pill.

    abstract::The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the ma...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(88)90008-x

    authors: Kjaergaard N,Kjaergaard B,Lauritsen JG

    更新日期:1988-06-01 00:00:00

  • Continuation of long-acting reversible contraceptives among Medicaid patients.

    abstract:OBJECTIVE:Our objective was to compare continuation and complication rates of subdermal etonogestrel implants and intrauterine devices (IUDs) using Medicaid insurance claims. STUDY DESIGN:We performed a retrospective cohort study using insurance claims data for 15- to 44-year-old subjects receiving implants or IUDs fr...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2018.04.012

    authors: Romano MJ,Toye P,Patchen L

    更新日期:2018-04-24 00:00:00

  • Removal of the LNG IUD when strings are not visible: a case series.

    abstract:OBJECTIVES:To report length of intrauterine device (IUD) and strings as well as technique for extraction when IUD removal occurs without visible strings. STUDY DESIGN:A prospective case series of 29 women who had IUDs removed in-office when strings were not visible at the external cervical os. RESULTS:One third (n=11...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.04.007

    authors: Swenson C,Royer PA,Turok DK,Jacobson JC,Amaral G,Sanders JN

    更新日期:2014-09-01 00:00:00

  • Another look at the Dalkon Shield: meta-analysis underscores its problems.

    abstract::Numerous non-comparative clinical trials of the Dalkon Shield appear to provide ample evidence that the Dalkon Shield was an effective IUD; they seem to yield little evidence that it was a dangerous device, nor markedly different from its contemporaries. Equating the performance of the Dalkon Shield IUD to that of the...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,meta分析,随机对照试验

    doi:10.1016/0010-7824(93)90060-k

    authors: Sivin I

    更新日期:1993-07-01 00:00:00

  • Mobile phone ownership, text messages, and contraceptive use: Is there a digital revolution in family planning?

    abstract:OBJECTIVES:This study aims to clarify the associations between mobile phone ownership use on family planning outcomes. Secondary analysis of DHS data finds that in certain contexts, mobile phone ownership may be related to increased FP uptake. STUDY DESIGN:Using recent data for women 15-49 from the Demographic and Hea...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.10.004

    authors: Jadhav A,Weis J

    更新日期:2020-02-01 00:00:00

  • Comparative contraceptive effectiveness of levonorgestrel-releasing and copper intrauterine devices: the European Active Surveillance Study for Intrauterine Devices.

    abstract:OBJECTIVES:The objective was to measure the rate of unintended pregnancies in women using levonorgestrel-releasing intrauterine systems (LNG IUSs, releasing 20 mcg LNG daily) and copper intrauterine devices (IUDs) in a typical population of IUD users and to describe associated complications. METHODS:A multinational, p...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.contraception.2015.01.011

    authors: Heinemann K,Reed S,Moehner S,Minh TD

    更新日期:2015-04-01 00:00:00

  • Bleeding patterns with monophasic and triphasic low-dose ethinyl estradiol combined oral contraceptives.

    abstract:BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of n...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2008.02.007

    authors: Hampton RM,Zhang HF,Barnowski C,Wan GJ

    更新日期:2008-06-01 00:00:00

  • Triphasic combination of ethinyl estradiol and gestodene. Long-term clinical trial.

    abstract::A triphasic oral contraceptive containing ethinyl estradiol and gestodene was used by 1933 women for up to 36 cycles in order to evaluate contraceptive efficacy, general tolerance and cycle control. Altogether, 30,763 treatment cycles were recorded. Two pregnancies were seen, both of them classified as user failure. T...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0010-7824(92)90128-g

    authors: Weber-Diehl F,Unger R,Lachnit U

    更新日期:1992-07-01 00:00:00

  • The incidence of gonorrhea in an abortion population.

    abstract::The incidence of gonorrhea was investigated in an abortion population. A total of 1021 women participated in this study. Three asymptomatic cases of gonorrhea were detected. None of these women had had gonorrhea before or had a previous abortion. No relation was found between the incidence of gonorrhea and age. The ab...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90028-1

    authors: Querido L,Haspels AA

    更新日期:1980-10-01 00:00:00

  • Delayed implantation induced by fadrozole hydrochloride in rats.

    abstract::The effect of aromatase inhibitors on the implantation process is not well known. This study examined the anti-implantation action in rats of a nonsteroidal aromatase inhibitor of high specific activity, fadrozole hydrochloride (Fad). Continuous subcutaneous infusion of Fad at 300 microg/day from Day 1 (the day of spe...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(03)00076-3

    authors: Tamada H,Mizuta Y,Kawate N,Inaba T,Sawada T

    更新日期:2003-07-01 00:00:00

  • Did increasing use of highly effective contraception contribute to declining abortions in Iowa?

    abstract:BACKGROUND:Between 2006 and 2008, Iowa increased access to family planning services through a Medicaid expansion and a privately funded initiative. During this same time, Iowa expanded access to abortion through telemedicine provision of medical abortion. Despite increased access to abortion services, abortions in Iowa...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2014.10.009

    authors: Biggs MA,Rocca CH,Brindis CD,Hirsch H,Grossman D

    更新日期:2015-02-01 00:00:00

  • Studies on mechanism(s) of antifertility action of gossypol in rat and hamster.

    abstract::This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90066-8

    authors: Srivastava A,Gupta G,Setty BS

    更新日期:1989-03-01 00:00:00

  • A comparative study of a progestin-only oral contraceptive versus non-hormonal methods in lactating women in Buenos Aires, Argentina.

    abstract::A non-randomized comparative clinical trial of the progestin-only oral contraceptive (POC), Ovrette (75 mcg norgestrel) (Wyeth), versus non-hormonal methods was conducted at two clinics in Buenos Aires, Argentina. The trial was designed to assess the breast-feeding patterns of women choosing progestin-only oral contra...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(91)90104-n

    authors: Moggia AV,Harris GS,Dunson TR,Diaz R,Moggia MS,Ferrer MA,McMullen SL

    更新日期:1991-07-01 00:00:00

  • A non-inferiority study of outpatient mifepristone-misoprostol medical abortion at 64-70 days and 71-77 days of gestation.

    abstract:OBJECTIVES:This open-label non-inferiority study assessed efficacy of a common outpatient medical abortion regimen among people with pregnancies 64-70 days and 71-77 days of gestation. STUDY DESIGN:We defined non-inferiority by a 6% margin of method success. People with intrauterine pregnancies 64-77 days' gestational...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.01.009

    authors: Dzuba IG,Chong E,Hannum C,Lichtenberg ES,Lugo Hernández EM,Ngoc NTN,Patel A,Rzayeva G,Sanhueza Smith P,Tsertsvadze G,Winikoff B

    更新日期:2020-05-01 00:00:00

  • Further studies on pituitary and ovarian function in women receiving hormonal contraception.

    abstract::Pituitary and ovarian function was evaluated in women receiving 3 combined oral contraceptive preparations. Basal levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) and gonadotropic responses to gonadotropic releasing hormone (GnRH) were studied in 36 healthy, regularly ovulating women in the ea...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(81)90089-5

    authors: Cohen BL,Katz M

    更新日期:1981-08-01 00:00:00

  • Contraceptive usage patterns in North American medical students.

    abstract:BACKGROUND:Previous studies indicate that the sexual beliefs and mores of students in medical professions may influence their capacity to care for patients' sexuality and contraception issues. Students also represent a large sample of reproductive-age individuals. In this study, we examined contraceptive usage patterns...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.09.011

    authors: Rowen TS,Smith JF,Eisenberg ML,Breyer BN,Drey EA,Shindel AW

    更新日期:2011-05-01 00:00:00

  • Exploring young women's decisional needs for contraceptive method choice: a qualitative study.

    abstract:OBJECTIVE:Assisting women with choosing contraceptive methods that meet their needs and preferences is essential to providing patient-centered care, but research to inform interventions supporting method choice is lacking. An assessment of patient decisional needs for contraceptive method choice may provide insight int...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.10.004

    authors: Marshall C,Kandahari N,Raine-Bennett T

    更新日期:2018-03-01 00:00:00

  • Ultrastructural changes in the spermatozoa of langur monkeys Presbytis entellus entellus after vas occlusion with styrene maleic anhydride.

    abstract::Changes in the physical characteristics of semen and ultrastructure of the spermatozoa of langur monkeys after vas occlusion with styrene maleic anhydride (SMA), a polymer with pH-lowering action, are reported. Vas occlusion resulted in severe reversible hypospermia. Severe oligospermia was observed in the majority of...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(98)00011-0

    authors: Lohiya NK,Manivannan B,Mishra PK

    更新日期:1998-02-01 00:00:00

  • Estimating systemic exposure to levonorgestrel from an oral contraceptive.

    abstract:OBJECTIVE:The gold standard for measuring oral contraceptive (OC) pharmacokinetics is the 24-h steady-state area under the curve (AUC). We conducted this study to assess whether limited sampling at steady state or measurements following use of one or two OCs could provide an adequate proxy in epidemiological studies fo...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.12.007

    authors: Basaraba CN,Westhoff CL,Pike MC,Nandakumar R,Cremers S

    更新日期:2017-04-01 00:00:00

  • Progestogen-only contraceptive use among breastfeeding women: a systematic review.

    abstract:BACKGROUND:The use of progestogen-only contraceptives by breastfeeding women raises theoretical concerns regarding possible adverse effects on breastfeeding success, and infant health or growth. This review was conducted to determine from the literature whether use of progestogen-only contraceptives by breastfeeding wo...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2010.02.002

    authors: Kapp N,Curtis K,Nanda K

    更新日期:2010-07-01 00:00:00

  • Contraceptive efficacy of lactational amenorrhea in urban Chilean women.

    abstract::The contraceptive efficacy of breastfeeding was assessed in 236 healthy urban women who were followed at monthly intervals during the first postpartum year. Proportional hazard models were used to evaluate the influence of time postpartum, menstrual status and breastfeeding pattern upon the risk of pregnancy. Time and...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90072-n

    authors: Díaz S,Aravena R,Cárdenas H,Casado ME,Miranda P,Schiappacasse V,Croxatto HB

    更新日期:1991-04-01 00:00:00

  • Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant.

    abstract::Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm o...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0010-7824(95)00263-4

    authors: Coutinho EM,de Souza JC,Athayde C,Barbosa IC,Alvarez F,Brache V,Gu ZP,Emuveyan EE,Adekunle AO,Devoto L,Shaaban MM,Salem HT,Affandi B,de Acosta OM,Mati J,Ladipo OA

    更新日期:1996-02-01 00:00:00

  • Effect of mefenamic acid on controlling irregular uterine bleeding in DMPA users.

    abstract::The objective of this double-blind, placebo-controlled study was to evaluate the effect of mefenamic acid and placebo on controlling irregular uterine bleeding in depot-medroxyprogesterone acetate (DMPA) users. A total of 48 DMPA users attending the Family Planning Clinic, Chulalongkorn Hospital were studied, all had ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.contraception.2004.04.003

    authors: Tantiwattanakul P,Taneepanichskul S

    更新日期:2004-10-01 00:00:00

  • Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.

    abstract:BACKGROUND:Music has served as an auxiliary analgesic in perioperative settings. This study evaluates the impact of intraoperative music added to routine pain control measures during first trimester surgical abortion. STUDY DESIGN:We analyzed data from 101 women randomized to undergo abortion with routine pain control...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2011.11.017

    authors: Guerrero JM,Castaño PM,Schmidt EO,Rosario L,Westhoff CL

    更新日期:2012-08-01 00:00:00

  • Cardiovascular risk factors in Norwegian women using oral contraceptives: results from a cardiovascular health screening 1985-88.

    abstract::We analyzed data from 4,905 women aged 20-39 and 14,803 aged 40-49 who attended a health survey in Norway 1985-88, to study cardiovascular risk factors in users of oral contraceptives, all types and specifically by formulation. In age group 20-39, users of low-dose estrogen/ progestin regimens were younger, had lower ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(96)00082-0

    authors: Graff-Iversen S,Tverdal A,Stensvold I

    更新日期:1996-06-01 00:00:00

  • Contraceptive use at last intercourse among reproductive-aged women with disabilities: an analysis of population-based data from seven states.

    abstract:OBJECTIVE:To assess patterns of contraceptive use at last intercourse among women with physical or cognitive disabilities compared to women without disabilities. STUDY DESIGN:We analyzed responses to 12 reproductive health questions added by seven states to their 2013 Behavioral Risk Factor Surveillance System questio...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2017.12.008

    authors: Haynes RM,Boulet SL,Fox MH,Carroll DD,Courtney-Long E,Warner L

    更新日期:2018-06-01 00:00:00

  • Use of hCG stimulation test in women immunized with beta-hCG vaccine.

    abstract::Eleven normally menstruating women, who had earlier been immunized with NII beta-hCG vaccine but had no detectable anti-hCG antibody titres, were selected as controls for the hCG challenge test using 1000/2000 I.U. The test was repeated in five of them after a booster immunization, which raised antibody titres to 18-4...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0010-7824(91)90035-e

    authors: Shahani SM,Patel KL

    更新日期:1991-10-01 00:00:00