Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant.

Abstract:

:Uniplant, a single Silastic implant containing nomegestrol acetate, provides contraceptive efficacy for one year. Uniplant use for one year was studied in 1,803 healthy women of reproductive age, enrolled from 10 centers in 9 countries, after informed consent. Implants were placed subdermally either in the upper arm or in the gluteal region. Two-hundred-seventy-six subjects discontinued prior to completing one year of study. Cumulative discontinuation rate at 12 months was 15.72%. Medical reasons for discontinuation were principally menstrual-related. Fifteen pregnancies occurred during the one year study period, resulting in a 12-month net cumulative pregnancy rate of 0.94%. Approximately 56% of subjects using Uniplant had bleeding patterns similar to normal menstruation. Results from this study confirm that Uniplant is an efficient, well tolerated, 12-month contraceptive implant, with the advantage of easier insertion and removal of the single implant compared to other multiple implant methods.

journal_name

Contraception

journal_title

Contraception

authors

Coutinho EM,de Souza JC,Athayde C,Barbosa IC,Alvarez F,Brache V,Gu ZP,Emuveyan EE,Adekunle AO,Devoto L,Shaaban MM,Salem HT,Affandi B,de Acosta OM,Mati J,Ladipo OA

doi

10.1016/0010-7824(95)00263-4

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

121-5

issue

2

eissn

0010-7824

issn

1879-0518

pii

0010782495002634

journal_volume

53

pub_type

临床试验,杂志文章,多中心研究
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    doi:10.1016/s0010-7824(86)80011-7

    authors: Gottardi G,Spreafico A,de Orchi L

    更新日期:1986-12-01 00:00:00

  • Effects of quinestrol on hepatic function in the rat.

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    doi:10.1016/s0010-7824(78)80021-3

    authors: Gioia IA,Lencioni LJ,Koch OR

    更新日期:1978-09-01 00:00:00

  • Comparative cross-over pharmacokinetic study on two types of postcoital contraceptive tablets containing levonorgestrel.

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(90)90064-3

    authors: He CH,Shi YE,Liao DL,Zhu YH,Xu JQ,Matlin SA,Vince PM,Fotherby K,Van Look PF

    更新日期:1990-05-01 00:00:00

  • Irregular bleeding, body mass index and coital frequency in Norplant contraceptive users.

    abstract::Seventy-five women with a mean age of 27.5 years who requested Norplant implants for contraception were studied over a five-year period. The patients kept daily diaries of their vaginal bleeding and coital frequency, and were seen at least every six months at which time their weight was measured. This study examines t...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/0010-7824(94)90047-7

    authors: Pasquale SA,Knuppel RA,Owens AG,Bachmann GA

    更新日期:1994-08-01 00:00:00

  • Five-year clinical experiences with NOVA T 380 copper IUD.

    abstract::In an open, single-group, phase III clinical trial of 5 years, the clinical performance of NOVA T 380 was investigated in three centers. The device having a higher copper surface of 380 mm(2) is a modification of NOVA T. A total of 400 voluntary women were enrolled in the study. The mean age was 31.4 years (SD 5.5) wi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/s0010-7824(02)00385-2

    authors: Batár I,Kuukankorpi A,Siljander M,Elomaa K,Rauramo I

    更新日期:2002-11-01 00:00:00

  • Metabolic investigations with Femodene--an oral contraceptive containing gestodene and ethinyloestradiol.

    abstract::The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femoden...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(87)90069-2

    authors: Fotherby K,Trayner I,Longthorne PN,Lee B,Watson HR

    更新日期:1987-04-01 00:00:00

  • Oral contraceptives and venous thromboembolism: a five-year national case-control study.

    abstract::The objective of this study was to assess the influence of oral contraceptives (OCs) on the risk of venous thromboembolism (VTE) in young women. A 5-year case-control study including all Danish hospitals was conducted. All women 15-44 years old, suffering a first ever deep venous thrombosis or a first pulmonary emboli...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(01)00307-9

    authors: Lidegaard Ø,Edström B,Kreiner S

    更新日期:2002-03-01 00:00:00

  • Interaction between phenytoin and norethisterone in the rhesus monkey.

    abstract::The effects of phenytoin treatment on plasma concentrations of norethisterone (NET) was studied in 7 healthy female rhesus monkeys. Before phenytoin treatment was started each monkey received an oral dose of 0.5 mg NET and 2 weeks later the same dose was given intravenously. On both occasions, plasma concentrations of...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(83)80021-3

    authors: Barkfeldt JO,Odlind V,Victor A

    更新日期:1983-04-01 00:00:00

  • Four-year experience in a randomized study of the Gyne T 380 Slimline and the Standard Gyne T 380 intrauterine copper devices.

    abstract::Performance of the Slimline and Standard models of the Gyne T 380 were measured through four years in a comparative study initially involving 996 women, seventy percent of whom were randomized to the Slimline device. Cumulative pregnancy rates of Slimline users were 0.3 +/- 0.2 per 100 both at three and at four years,...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(93)90107-i

    authors: Sivin I,Diaz J,Alvarez F,Brache V,Diaz S,Pavez M,Stern J

    更新日期:1993-01-01 00:00:00

  • Women's knowledge of their state's abortion regulations. A national survey.

    abstract:OBJECTIVES:States vary significantly in their regulation of abortion. Misinformation about abortion is pervasive and propagated by state-mandated scripts that contain abortion myths. We sought to investigate women's knowledge of abortion laws in their state. Our secondary objective was to describe women's ability to di...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.08.001

    authors: Swartz JJ,Rowe C,Morse JE,Bryant AG,Stuart GS

    更新日期:2020-11-01 00:00:00

  • The hormonal and immunological status of vasectomised men.

    abstract::The concentration of FSH, LH, testosterone and sperm agglutinating and cytotoxic antibodies have been determined in 87 men at varying time intervals after vasectomy. The results indicated that vasectomy is not associated with statistically significant changes in any of these parameters. Furthermore, no correlation exi...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(79)90007-6

    authors: Tyler JP,Richardson DW,Newton JR

    更新日期:1979-06-01 00:00:00

  • Bioavailability of the Yuzpe and levonorgestrel regimens of emergency contraception: vaginal vs. oral administration.

    abstract::Separate crossover studies compared the bioavailability of oral vs. vaginal routes of administration for the Yuzpe (n=5) and levonorgestrel regimens (n=4) of emergency contraception. Twice the standard dose of the Yuzpe regimen (200 microg of ethinyl estradiol, 1000 microg of levonorgestrel) or the levonorgestrel regi...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

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    authors: Kives S,Hahn PM,White E,Stanczyk FZ,Reid RL

    更新日期:2005-03-01 00:00:00

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.11.014

    authors: Liu SM,Flink-Bochacki R

    更新日期:2020-12-04 00:00:00

  • Medications to ease intrauterine device insertion: a systematic review.

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    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2016.06.014

    authors: Zapata LB,Jatlaoui TC,Marchbanks PA,Curtis KM

    更新日期:2016-12-01 00:00:00

  • A study of the relationship between tensile testing of condoms and breakage in use.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90045-h

    authors: Gerofi J,Shelley G,Donovan B

    更新日期:1991-02-01 00:00:00

  • Inhibition of Chlamydia trachomatis growth in endometrial cells by copper: possible relevance for the use of the copper IUD.

    abstract::There is agreement that the relative risk of developing pelvic inflammatory disease (PID) increases among women who use the intrauterine contraceptive device (IUD). The role of Chlamydia in causing PID among IUD users is not clear. The present study demonstrates that Chlamydia trachomatis growth can be inhibited in cu...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90041-3

    authors: Kleinman D,Sarov I,Insler V

    更新日期:1989-06-01 00:00:00

  • Buccal misoprostol as cervical preparation for second trimester pregnancy termination.

    abstract::The objective of the study was to assess the efficacy of cervical preparation with misoprostol or laminaria suction abortion up to 18 weeks gestation. The study was conducted among a consecutive case series of patients presenting for dilatation and evacuation at a single center. Cervical preparation was effected by ei...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00306-2

    authors: Todd CS,Soler M,Castleman L,Rogers MK,Blumenthal PD

    更新日期:2002-06-01 00:00:00

  • Comparison of outcomes at 6 weeks following postpartum intrauterine contraceptive device insertions by doctors and nurses in India: a case-control study.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2015.12.012

    authors: Yadav V,Balasubramaniam S,Das S,Srivastava A,Srivastava A,Kumar S,Sood B

    更新日期:2016-04-01 00:00:00

  • Evaluation of the effect of a patient decision aid about vasectomy on the decision-making process: a randomized trial.

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    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2010.05.003

    authors: Labrecque M,Paunescu C,Plesu I,Stacey D,Légaré F

    更新日期:2010-12-01 00:00:00

  • Apoptosis occurs in implantation site of the rhesus monkey during early stage of pregnancy.

    abstract::The exact role of apoptosis that occurs in human placenta during the early stage of pregnancy remains unknown because of the difficulty in obtaining the intact implantation site. In this study, we used rhesus monkey as an animal model to examine apoptosis occurring in the implantation site at various stages of early p...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(01)00241-4

    authors: Fei G,Peng W,Xin-Lei C,Zhao-Yuan H,Yi-Xun L

    更新日期:2001-09-01 00:00:00

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    abstract::Plasma concentrations of levonorgestrel, progesterone, estradiol, FSH and LH were measured in seven volunteers who had a levonorgestrel-releasing IUD inserted postmenstrually. Blood samples were collected twice weekly during a mean of 93 days immediately postmenstrually and during a mean of 41 days over the twelfth to...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(80)90003-7

    authors: Nilsson CG,Lähteenmäki P,Luukkainen T

    更新日期:1980-03-01 00:00:00

  • Subcutaneous DMPA vs. intramuscular DMPA: a 2-year randomized study of contraceptive efficacy and bone mineral density.

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    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2009.02.005

    authors: Kaunitz AM,Darney PD,Ross D,Wolter KD,Speroff L

    更新日期:2009-07-01 00:00:00

  • Safety data for levonorgestrel, ulipristal acetate and Yuzpe regimens for emergency contraception.

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    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2015.11.001

    authors: Jatlaoui TC,Riley H,Curtis KM

    更新日期:2016-02-01 00:00:00

  • Comparative multicentre trial of three IUDs inserted immediately following delivery of the placenta.

    abstract::A multinational comparative trial of three IUDs (Copper 7, Lippes loop size D and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in six centres. A total of 841 women entered the study. As the predetermined termination indices for expulsions were exceeded at six months ...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(80)90112-2

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    更新日期:1980-07-01 00:00:00

  • Competition between seminal and exogenous proteinase inhibitors for sites on murine epididymal sperm.

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    pub_type: 杂志文章

    doi:10.1016/0010-7824(85)90032-0

    authors: Aarons D,Robinson R,Richardson R,Poirier GR

    更新日期:1985-02-01 00:00:00

  • Conditions in rural Nepal for which depot-medroxyprogesterone acetate initiation is not recommended: implications for community-based service delivery.

    abstract::The presence of medical conditions that might affect the use of depot-medroxyprogesterone acetate (DMPA) as a contraceptive method was assessed in a rural district in Nepal. A general health survey was conducted in nonpregnant and noncontracepting women aged 15-44 years to determine the presence of any health problems...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(99)00056-6

    authors: Rai C,Thapa S,Day J,Bhattarai L,McMullen S,Jha R,Shrestha S,Bastola S,Rivera R

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  • A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy.

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(03)00170-7

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    更新日期:2003-10-01 00:00:00

  • Long-term use of depot-norethisterone enanthate: effect on blood coagulation factors and menstrual bleeding patterns.

    abstract::Fifty-six women using depot-norethisterone enanthate injections for contraception for 2 years or more were compared with a control group of 48 women not using hormonal contraception. No significant difference was found between the study group and controls for Factors VIIc and Antithrombin III. Factor Xc was reduced in...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(91)90083-r

    authors: McEwan JA,Griffin M

    更新日期:1991-12-01 00:00:00

  • Emergency contraception in South Africa: knowledge, attitudes, and use among public sector primary healthcare clients.

    abstract::To determine knowledge of, attitudes toward, and use of emergency contraception (EC), interviews were held with 1068 clients of 89 public sector primary healthcare facilities in two urban and two rural areas of South Africa. Only 22.8% of the clients had heard of EC. Awareness was significantly lower in the most rural...

    journal_title:Contraception

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0010-7824(01)00272-4

    authors: Smit J,McFadyen L,Beksinska M,de Pinho H,Morroni C,Mqhayi M,Parekh A,Zuma K

    更新日期:2001-12-01 00:00:00

  • Effects of low doses of mifepristone on human embryo implantation process in a three-dimensional human endometrial in vitro co-culture system.

    abstract:OBJECTIVES:We wanted to explore the effects of two different low doses (0.5μM and 0.05μM) of mifepristone, exposed during the receptive period, on the human embryo implantation process, using a well-established three-dimensional in vitro cell culture model, specifically developed to study this process. METHODS:An in v...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2016.03.009

    authors: Boggavarapu NR,Berger C,von Grothusen C,Menezes J,Gemzell-Danielsson K,Lalitkumar PG

    更新日期:2016-08-01 00:00:00