Abstract：
:Sixteen proteinase inhibitors were tested for their ability to compete with the natural seminal inhibitor for binding to the surface of murine epididymal sperm. The most effective competitors, 4-methylumbelliferyl-p-quanidinobenzoate (MUGB) and p-nitrophenyl-p-guanidinobenzoate (NPGB), are also effective inhibitors of both murine acrosin and in vitro fertilization of mouse gametes. The data support the suggestion that the inhibition of fertilization by these inhibitors may be effected by their action on the sperm surface rather than binding to enzymes located within the acrosome. Since the surface acceptor molecule recognizes a number of inhibitor types, as well as substrates for such enzymes as trypsin and acrosin, the acceptor's binding site may be similar to the active site on the enzyme.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Aarons D,Robinson R,Richardson R,Poirier GRdoi
10.1016/0010-7824(85)90032-0subject
Has Abstractpub_date
1985-02-01 00:00:00pages
177-84issue
2eissn
0010-7824issn
1879-0518pii
0010-7824(85)90032-0journal_volume
31pub_type
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