Comparative cross-over pharmacokinetic study on two types of postcoital contraceptive tablets containing levonorgestrel.

abstract：BACKGROUND:Maternal trisomy 21 ovarian mosaicism might provide the major causative factor for fetal Down syndrome. The small proportion of trisomy 21 oocytes thought to be retarded in their maturation in comparison to normal disomic ones, and the maternal age effect can be based on an accumulation of trisomy 21 oocytes...

journal_title：Contraception

authors： Nagy GR,Győrffy B,Nagy B,Rigó J Jr

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:While the intra-uterine device (IUD) is the second most popular contraceptive method in France, its use remains low among women most at risk of unintended pregnancies. Acknowledging the conjoint role of women and physicians in contraceptive decision making, we investigate the determinants of IUD use and IUD r...

journal_title：Contraception

authors： Moreau C,Bohet A,Hassoun D,Ringa V,Bajos N,FECOND group.

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Abortion in Turkey has been legal since 1983 and remains so today. Despite this, in 2012 the Prime Minister declared that, in his opinion, abortion was murder. Since then, there has been growing evidence that abortion access particularly in state hospitals is being restricted, although no new legislation h...

journal_title：Contraception

authors： O'Neil ML

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Between 2006 and 2008, Iowa increased access to family planning services through a Medicaid expansion and a privately funded initiative. During this same time, Iowa expanded access to abortion through telemedicine provision of medical abortion. Despite increased access to abortion services, abortions in Iowa...

journal_title：Contraception

authors： Biggs MA,Rocca CH,Brindis CD,Hirsch H,Grossman D

更新日期：2015-02-01 00:00:00

abstract：:A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study the pharmacokinetics of a single dose of 50 mg RU 486 administered orally to 12 women on day 7 of the cycle. The dose was rapidly absorbed with peak plasma concentration between 1 and 2 hours. Distribution was also rapid (me...

journal_title：Contraception

authors： He CH,Shi YE,Ye ZH,Zhang GG,Jiang NX,Van Look PF,Fotherby K

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVE:Understanding the effect of contraceptives on the development of precancerous lesions of the cervix and cervical cancer may provide information that is valuable to women in contraceptive decision-making. The purpose of this study was to evaluate the association between recent intrauterine device (IUD) use (by...

journal_title：Contraception

authors： Averbach S,Silverberg MJ,Leyden W,Smith-McCune K,Raine-Bennett T,Sawaya GF

更新日期：2018-04-17 00:00:00

abstract：:Benzene extractives of Hibiscus rosa-sinensis flowers, administered during day 1-4 of gestation, exerted anti-implantation effect without affecting the tubal transport of zygote. On day 4, normal number of blastocyst was present in the uterus but they did not implant. However, as studied by pontamine blue reaction, it...

journal_title：Contraception

authors： Pal AK,Bhattacharya K,Kabir SN,Pakrashi A

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:To describe the efficacy, safety, and acceptability of medical abortion in the late first trimester. STUDY DESIGN:We searched PubMed and Cochrane databases for articles in any language that examined the success of medical abortion at gestational ages (>63 to≤84 days gestation). We sought articles that compar...

journal_title：Contraception

authors： Kapp N,Eckersberger E,Lavelanet A,Rodriguez MI

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Doxycycline is commonly used for antibiotic prophylaxis before dilation and evacuation (D&E) but frequently causes nausea and emesis which may affect absorption and effectiveness. Taking doxycycline the night prior to surgery may result in adequate absorption with better tolerance. STUDY DESIGN:We enrolled ...

journal_title：Contraception

authors： Reeves MF,Lohr PA,Hayes JL,Harwood BJ,Creinin MD

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Emergency contraception (EC) does not always work. Clinicians should be aware of potential risk factors for EC failure. STUDY DESIGN:Data from a meta-analysis of two randomized controlled trials comparing the efficacy of ulipristal acetate (UPA) with levonorgestrel were analyzed to identify factors associat...

journal_title：Contraception

authors： Glasier A,Cameron ST,Blithe D,Scherrer B,Mathe H,Levy D,Gainer E,Ulmann A

更新日期：2011-10-01 00:00:00

abstract：:Patients taking anticonvulsants such as phenobarbitone, phenytoin and carbamazepine together with their oral contraceptive steroid may suffer contraceptive failure because of the enzyme-inducing properties of these anticonvulsants. We have examined, in six women, the effect of sodium valproate, an effective broad spec...

journal_title：Contraception

authors： Crawford P,Chadwick D,Cleland P,Tjia J,Cowie A,Back DJ,Orme ML

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:This prospective study aimed to assess the possible effects of the levonorgestrel-releasing intrauterine system (LNG-IUS) on serum lipids and fasting blood glucose levels over a period of 1 year. METHODS:Forty-eight premenopausal women, attending our gynecology clinic with the complaint of menorrhagia, were en...

journal_title：Contraception

authors： Kayikcioglu F,Gunes M,Ozdegirmenci O,Haberal A

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To assess the cost-effectiveness of self-injected subcutaneous depot medroxyprogesterone acetate (DMPA-SC) compared to health-worker-administered intramuscular DMPA (DMPA-IM) in Uganda. STUDY DESIGN:We developed a decision-tree model with a 12-month time horizon for a hypothetical cohort of approximately 1 m...

journal_title：Contraception

authors： Di Giorgio L,Mvundura M,Tumusiime J,Morozoff C,Cover J,Drake JK

更新日期：2018-11-01 00:00:00

abstract：:Gossypol, a polyphenolic pigment found in cotton plants, has been implicated as an antifertility agent. This pigment has been shown to alter myriad metabolic pathways. The objective of this study was to determine the effect of gossypol acetic acid on the hepatic microsomal drug metabolizing enzyme system in adult fema...

journal_title：Contraception

authors： Johansen RL,Misra HP

更新日期：1990-12-01 00:00:00

abstract：:This study examines the efficacy and side effects of 15-methyl-prostaglandins F2alpha (PGF2a) free acid administered intramuscularly for midtrimester abortion. 50 healthy women aged 14 to 37 years and between 12 to 18 weeks gestation were randomly selected from the abortion clinic at the Los Angeles County/USC Medica...

journal_title：Contraception

authors： Slaughter L,Ballard CA

更新日期：1975-05-01 00:00:00

abstract：:Effect of antiestrogen ormeloxifene on progesterone-induced development of giant mitochondria in uterine glandular epithelial cells in ovariectomized adult Sprague-Dawley rats was investigated. Antiestrogen tamoxifen and antiprogestin onapristone were used for comparison. Well-formed giant mitochondria were observed i...

journal_title：Contraception

authors： Chauhan SC,Singh MM,Maitra SC,Kamboj VP

更新日期：1996-10-01 00:00:00

abstract：:The objective of this study was to evaluate use of a cauda epididymis extract (CEE) as an immunocontraceptive in rats. Twenty-two rats in puberty or 19 rats that gave birth once (primipara) were immunized with intraperitoneal (IP) injection of CEE. Rats in puberty received one or two injections of CEE containing 1.5 x...

journal_title：Contraception

authors： Risvanli A,Aydin M,Kaygusuzoglu E,Bulut H,Apaydin AM,Timurkan H

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:This retrospective analysis evaluated the association of age and weight with cycle control in women using either of two formulations of low-estrogen-dose oral contraceptives. STUDY DESIGN:Data for this secondary analysis were derived from a randomized multicenter trial assessing the efficacy and safety of n...

journal_title：Contraception

authors： Hampton RM,Zhang HF,Barnowski C,Wan GJ

更新日期：2008-06-01 00:00:00

abstract：:Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...

journal_title：Contraception

authors： Back DJ,Breckenridge AM,Chapman CR,Crawford FE,Olsen KA,Orme ML,Rowe PH

更新日期：1981-02-01 00:00:00

abstract：:Intrauterine devices releasing 20 micrograms/day levonorgestrel were inserted in 10 women (ages 25-34). Bleeding and spotting patterns were recorded on a menstrual card during one year of follow-up. Blood samples were collected for radioimmunoassays of LH, estradiol (E2), progesterone (P) and levonorgestrel (LNG) and ...

journal_title：Contraception

authors： Xiao BL,Zhou LY,Zhang XL,Jia MC,Luukkainen T,Allonen H

更新日期：1990-04-01 00:00:00

abstract：:The study reported herein is the primary efficacy and safety study conducted to support U.S. registration of an oral contraceptive containing 150 micrograms desogestrel and 30 micrograms ethinyl estradiol. A large multicenter study enrolled 1,221 women at 50 centers in the United Kingdom. A total of 11,656 cycles of e...

journal_title：Contraception

authors： Walling M

更新日期：1992-10-01 00:00:00

abstract：:The mode of antifertility action of intrauterine neem treatment (IUNT) was studied. The effect of IUNT on ovarian functions and uterine responsiveness to ovarian hormones was examined in adult Wistar rats. The treated animals had normal reproductive cycles as indicated by the vaginal smears; serum progesterone levels ...

journal_title：Contraception

authors： Kaushic C,Upadhyay S

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:To describe clinical outcomes of etonogestrel implant patients with migration to the vasculature, chest wall and other distant body sites spontaneously reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. STUDY DESIGN:We performed a standardized Medical Dictionary ...

journal_title：Contraception

authors： Kang S,Niak A,Gada N,Brinker A,Jones SC

更新日期：2017-12-01 00:00:00

abstract：:Kauradienoic acid was obtained from the hexanic extract of M. tomentosa (Cerv) leaves by chromatographic separation. This substance influenced the in vitro contractility of the rat, dog and guinea pig uterine strips. It also induced strong contractions of the guinea pig uterus in vivo when administered intravenously, ...

journal_title：Contraception

authors： Lozoya X,Enríquez RG,Bejar E,Estrada AV,Girón H,Ponce-Monter H,Gallegos AJ

更新日期：1983-03-01 00:00:00

abstract：:Community-based distribution (CBD) programs are the optimum way of reaching people in rural areas of developing countries where conventional methods of delivery do not exist or fail. This paper reviews findings and experiences from over 30 years of efforts to implement CBD of family planning methods around the world. ...

journal_title：Contraception

authors： Prata N,Vahidnia F,Potts M,Dries-Daffner I

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Although widely used, the mechanisms of action of the levonorgestrel emergency contraceptive pill (LNG ECP) are still unclear. There are increasing data to indicate that LNG is particularly effective as an ECP by interrupting follicular development and ovulation. An important outstanding question is whether ...

journal_title：Contraception

authors： Novikova N,Weisberg E,Stanczyk FZ,Croxatto HB,Fraser IS

更新日期：2007-02-01 00:00:00

abstract：:Because RU 486 synergizes with anordrin and its dihydroxylated metabolite to terminate established pregnancy in the rat and rabbit, the interactions of these agents were studied at two days postcoitally in the rat. RU 486 at a dose of 4 mg/kg did not prevent pregnancy when the animals were killed 12 days post insemina...

journal_title：Contraception

authors： Chang CC,Wang WC,Bardin CW

更新日期：1993-04-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamic effects of two doses of norethisterone (5mg and 3mg) used as a 'visiting pill' were investigated. There were no significant differences in the pharmacokinetics of the two doses except for the peak concentration achieved and the bioavailability as assessed by the area under the ...

journal_title：Contraception

authors： Song S,Chen JK,Yang PJ,Cheng DH,Liu WY,Fotherby K

更新日期：1986-09-01 00:00:00

abstract：:Ovarian function, bleeding patterns and serum lipoproteins were studied in women using contraceptive vaginal rings (CVRs) of dimethyl-polysiloxane impregnated with steroids. The different CVRs were used for about 10 cycles each. The following groups were studied, with the daily steroid dosage given in parentheses. Wom...

journal_title：Contraception

authors： Ahrén T,Victor A,Lithell H,Vessby B,Jackanicz TM,Johansson ED

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:A previous investigation showed that among 120 healthy women treated with a single oral dose of gestrinone for emergency contraception (EC), there was only one pregnancy. The effect of a single oral dose of gestrinone given for EC on ovarian function and endometrial development was studied. STUDY DESIGN:Hea...

journal_title：Contraception

authors： Gao X,Wu E,Chen G

更新日期：2007-09-01 00:00:00