Abstract：
:Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed marked hydrolytic activity in vitro, but there was little hydrolysis of NET OEN by either human muscle or fat. It is proposed that following intramuscular administration of NET OEN to rabbits, the ester is rapidly hydrolysed at the injection site and in the circulation whereas in humans the liver is the main site of hydrolysis since neither muscle nor plasma cause significant breakdown of the ester. The rabbit is not a good model for predicting the pharmacokinetics of NET OEN in humans.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Back DJ,Breckenridge AM,Chapman CR,Crawford FE,Olsen KA,Orme ML,Rowe PHdoi
10.1016/0010-7824(81)90098-6subject
Has Abstractpub_date
1981-02-01 00:00:00pages
125-32issue
2eissn
0010-7824issn
1879-0518pii
0010-7824(81)90098-6journal_volume
23pub_type
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