Abstract：
:STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4.9(10)-diene-3-one) is a potent progestin. This compound was 10 times as potent as the standard levonorgestrel as judged by the classic Clauberg-McPhail Assay. The antiprogestational response is significant when STS 557 treatment starts 2 days before progesterone administration. It does not disturb the priming activity of estradiol. This compound alone is adequate for endometrial priming. Early pregnancy is maintained in ovariectomized does. Administration on day 1 of pregnancy reduces the number of implantations. In comparison with chlormadinone acetate and d-norgestrel, only STS 557 treatment causes complete inhibition of egg fertilization.
journal_name
Contraceptionjournal_title
Contraceptionauthors
Oettel M,Kurischko Adoi
10.1016/0010-7824(80)90140-7subject
Has Abstractpub_date
1980-01-01 00:00:00pages
61-9issue
1eissn
0010-7824issn
1879-0518pii
0010-7824(80)90140-7journal_volume
21pub_type
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