The effects of spermicides containing nonoxynol-9 on cervical cytology.

Abstract:

BACKGROUND:This analysis was undertaken to compare the effect of the different dosages and formulations of spermicides containing nonoxynol-9 (N-9) on cervical cytology. STUDY DESIGN:A randomized trial was conducted at 14 sites in the United States to evaluate the effectiveness and safety of five spermicides containing N-9. This Papanicolaou smear analysis included the data from all participants who provided two Papanicolaou smear samples: at admission and after discontinuation of the product. The effects of the spermicides were evaluated by comparing the rates of alteration of cervical cytology between five study groups. RESULTS:A total of 640 women were included in this analysis. The majority of the study participants (>85%) had no change of their baseline Papanicolaou smear result. The rates of alteration of cervical cytology were similar among women using the three gels containing the different doses of N-9 and three different formulations containing the same dose of N-9. Our analysis found no association between alteration of cervical cytology and duration or frequency of use of the five study spermicides. CONCLUSIONS:Exposure to different formulations and doses of spermicides containing N-9 is unlikely to influence cervical cytology.

journal_name

Contraception

journal_title

Contraception

authors

Halpern V,Rountree W,Raymond EG,Law M

doi

10.1016/j.contraception.2007.11.015

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

191-4

issue

3

eissn

0010-7824

issn

1879-0518

pii

S0010-7824(07)00516-1

journal_volume

77

pub_type

杂志文章,多中心研究,随机对照试验
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    更新日期:2017-01-01 00:00:00

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    abstract:OBJECTIVE:To examine from the health care services payer perspective the economic consequences of contraceptives available to women in the United States. METHODS:A Markov model was constructed to compare effectiveness and costs among nine contraceptive methods (including 3-month injectable, oral contraceptives, intrau...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(03)00078-7

    authors: Chiou CF,Trussell J,Reyes E,Knight K,Wallace J,Udani J,Oda K,Borenstein J

    更新日期:2003-07-01 00:00:00

  • Comparative study of the effects of two once-a-month injectable steroidal contraceptives (Mesigyna and Cyclofem) on lipid and lipoprotein metabolism. United Nations Development Programme/United Nations Population Fund/World Health Organization/World Bank,

    abstract::A 1-year longitudinal multicenter study was undertaken to monitor the effects on lipid metabolism of two once-a-month injectable contraceptive preparations, Mesigyna (50 mg norethisterone enanthate and 5 mg estradiol valerate and Cyclofem (25 mg medroxyprogesterone acetate and 5 mg estradiol cypionate). A total of 357...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors:

    更新日期:1997-10-01 00:00:00

  • Emergency contraception in Jordan: Assessing retail pharmacists' awareness, opinions, and perceptions of need.

    abstract:OBJECTIVES:Jordan has a robust contraceptive method mix in both the public and private sectors and oral contraceptive pills and the copper-T intrauterine device are widely available. However, Jordan remains one of only a few countries in the world without a registered dedicated product for emergency contraception (EC)....

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.10.002

    authors: El-Mowafi IM,Foster AM

    更新日期:2020-04-01 00:00:00

  • Effects of ethinyl estradiol and ibuprofen compared to placebo on endometrial bleeding, cervical mucus and the postcoital test in levonorgestrel subcutaneous implant users.

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    journal_title:Contraception

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.contraception.2008.04.003

    authors: Archer DF,Philput CB,Levine AS,Cullins V,Stovall TG,Bacon J,Weber ME

    更新日期:2008-08-01 00:00:00

  • Endometrial estradiol-17 beta-dehydrogenase activity in women wearing Cu-IUD.

    abstract::In order to determine whether inhibition of the endometrial estradiol-17 beta-dehydrogenase activity by Cu++ could be one of the factors accounting for the enhanced contraceptive efficacy of copper intrauterine devices (Cu-IUD), the activity of the enzyme was measured in endometrial biopsies from women wearing this de...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(79)90019-2

    authors: Tseng L,Dramusic V,Gurpide E

    更新日期:1979-03-01 00:00:00

  • Availability of pharmacist prescription of contraception in rural areas of Oregon and New Mexico.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2019.11.005

    authors: Rodriguez MI,Garg B,Williams SM,Souphanavong J,Schrote K,Darney BG

    更新日期:2020-03-01 00:00:00

  • Worldwide use of intrauterine contraception: a review.

    abstract:BACKGROUND:Globally, 14.3% of women of reproductive age use intrauterine contraception (IUC), but the distribution of IUC users is strikingly nonuniform. In some countries, the percentage of women using IUC is <2%, whereas in other countries, it is >40%. Reasons for this large variation are not well documented. The aim...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2013.11.011

    authors: Buhling KJ,Zite NB,Lotke P,Black K,INTRA Writing Group.

    更新日期:2014-03-01 00:00:00

  • Effects of the levonorgestrel-releasing intrauterine system on cervical mucus quality and sperm penetrability.

    abstract:BACKGROUND:In levonorgestrel intrauterine system (LNG-IUS) users, the prevention of sperm penetration through cervical mucus has not been demonstrated. STUDY DESIGN:Subjects were enrolled in an investigator-blinded study to compare quality and sperm penetrability of mid-cycle cervical mucus between LNG-IUS users and h...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.contraception.2010.06.006

    authors: Lewis RA,Taylor D,Natavio MF,Melamed A,Felix J,Mishell D Jr

    更新日期:2010-12-01 00:00:00

  • A phase I study of Femcap used with and without spermicide. Postcoital testing.

    abstract::The objectives of the study were to assess the ability of the Femcap, a new vaginal contraceptive device made of silicone and designed to fit snugly around the cervix to prevent the penetration of sperm into midcycle cervical mucus when used with and without spermicide; and to compare it with the standard contraceptiv...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0010-7824(97)00098-x

    authors: Mauck CK,Baker JM,Barr SP,Johanson W,Archer DF

    更新日期:1997-08-01 00:00:00

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    abstract:BACKGROUND:Little is known about the out-of-pocket expenditures and dispensing patterns for oral contraceptive pills (OCPs), factors associated with these outcomes and whether they change over time. STUDY DESIGN:Observational cohort using 1996-2006 Medical Expenditure Panel Surveys. RESULTS:Women spent $16 out-of-poc...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2010.09.013

    authors: Liang SY,Grossman D,Phillips KA

    更新日期:2011-06-01 00:00:00

  • Can mifepristone medical abortion be simplified? A review of the evidence and questions for future research.

    abstract::Mifepristone medical abortion has been a valuable addition to the reproductive health options of women. Aspects of its provision have however sometimes limited its accessibility and use. This article summarizes existing evidence for simplifying the provision of medical abortion and thus increasing its availability. We...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2006.11.011

    authors: Clark WH,Gold M,Grossman D,Winikoff B

    更新日期:2007-04-01 00:00:00

  • A comparative study of Neo Sampoon, Ortho Vaginal Tablets and Emko Vaginal Tablets in Accra, Ghana.

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(85)90015-0

    authors: Lamptey P,Klufio C,Smith SC,Feldblum PJ

    更新日期:1985-11-01 00:00:00

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00317-7

    authors: Singh K,Fong YF,Loh SY

    更新日期:2002-07-01 00:00:00

  • Antichlamydial activity of cervical secretion in different phases of the menstrual cycle and influence of hormonal contraceptives.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(94)90044-2

    authors: Mahmoud EA,Hamad EE,Olsson SE,Mårdh PA

    更新日期:1994-03-01 00:00:00

  • Associations between immediate postpartum long-acting reversible contraception and short interpregnancy intervals.

    abstract:OBJECTIVE:We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. STUDY DESIGN:We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this c...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/j.contraception.2020.08.016

    authors: Wu M,Eisenberg R,Negassa A,Levi E

    更新日期:2020-12-01 00:00:00

  • Inhibition of Chlamydia trachomatis growth in endometrial cells by copper: possible relevance for the use of the copper IUD.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(89)90041-3

    authors: Kleinman D,Sarov I,Insler V

    更新日期:1989-06-01 00:00:00

  • Medications to ease intrauterine device insertion: a systematic review.

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    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2016.06.014

    authors: Zapata LB,Jatlaoui TC,Marchbanks PA,Curtis KM

    更新日期:2016-12-01 00:00:00

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(74)90049-3

    authors: Berman R,Hale RW,Reich LA,Pion RJ

    更新日期:1974-06-01 00:00:00

  • Contraceptive failure in the United States.

    abstract::This review provides an update of previous estimates of first-year probabilities of contraceptive failure for all methods of contraception available in the United States. Estimates are provided of probabilities of failure during typical use (which includes both incorrect and inconsistent use) and during perfect use (c...

    journal_title:Contraception

    pub_type: 杂志文章,评审

    doi:10.1016/j.contraception.2011.01.021

    authors: Trussell J

    更新日期:2011-05-01 00:00:00

  • An integrated analysis of vaginal bleeding patterns in clinical trials of Implanon.

    abstract::The vaginal bleeding patterns observed during the use of the single-rod progestin-only implant, Implanon, compared with those seen during the use of the six-capsule implant, Norplant, have been analyzed. The acceptability of these bleeding patterns was also assessed. An integrated analysis of 13 different trials was d...

    journal_title:Contraception

    pub_type: 杂志文章,meta分析,收录出版

    doi:10.1016/s0010-7824(98)00123-1

    authors: Affandi B

    更新日期:1998-12-01 00:00:00

  • Effect of a new injectable male contraceptive on the seminal plasma amino acids studied by proton NMR spectroscopy.

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    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/s0010-7824(02)00343-8

    authors: Chaudhury K,Sharma U,Jagannathan NR,Guha SK

    更新日期:2002-09-01 00:00:00

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(01)00307-9

    authors: Lidegaard Ø,Edström B,Kreiner S

    更新日期:2002-03-01 00:00:00

  • Two-year treatment with oral contraceptives in hyperprolactinemic patients.

    abstract::The aim of this prospective study was the follow-up for 2 years in symptoms, serum prolactin (PRL) levels, and radiological aspects of a group of young patients using oral contraceptives (OC) with hyperprolactinemia. A total of 16 hyperprolactinemic women (eight with idiopathic hyperprolactinemia and eight with pituit...

    journal_title:Contraception

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0010-7824(98)00069-9

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    更新日期:1998-08-01 00:00:00

  • Studies on the enzymatic cleavage of norethisterone oenanthate.

    abstract::Norethisterone oenanthate (NET OEN) was extensively hydrolysed in rabbit, rat and guinea pig plasma (99.9%, 76.1% and 46.0% hydrolysed in 90 min, respectively). In contrast, there was negligible hydrolysis (less than 2.5%) in dog, goat and human plasma. Rabbit liver, kidney, gut wall, stomach, heart and muscle showed ...

    journal_title:Contraception

    pub_type: 杂志文章

    doi:10.1016/0010-7824(81)90098-6

    authors: Back DJ,Breckenridge AM,Chapman CR,Crawford FE,Olsen KA,Orme ML,Rowe PH

    更新日期:1981-02-01 00:00:00

  • A comparative study of the levonorgestrel-releasing intrauterine system Mirena versus the Copper T380A intrauterine device during lactation: breast-feeding performance, infant growth and infant development.

    abstract:BACKGROUND:Mirena is a levonorgestrel-releasing intrauterine system (LNG-IUS) that provides highly effective and long-acting progestogen-only contraception. OBJECTIVE:The objective of this study was to analyze the possible effects of using LNG-20 microg IUS on breast-feeding performance, infant growth and infant devel...

    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

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    更新日期:2005-11-01 00:00:00

  • A randomized comparative study of the performance of seven different sizes of the Mahua Ring inserted following measurement of the uterine cavity and one size of the same ring.

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    journal_title:Contraception

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0010-7824(90)90048-z

    authors: Juan QL,Zhi LJ,Juan SL,Yi WM,Wu GM

    更新日期:1990-10-01 00:00:00

  • Safety of intrauterine devices among women with HIV: a systematic review.

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    journal_title:Contraception

    pub_type: 杂志文章,评审

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    authors: Tepper NK,Curtis KM,Nanda K,Jamieson DJ

    更新日期:2016-12-01 00:00:00

  • Effect of a single vaginal administration of levonorgestrel in Carraguard gel on the ovulatory process: a potential candidate for "dual protection" emergency contraception.

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    journal_title:Contraception

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.contraception.2007.04.005

    authors: Brache V,Croxatto H,Sitruk-Ware R,Maguire R,Montero JC,Kumar N,Salvatierra AM,Tejada AS,Cochón L,Forcelledo ML,Lahteenmaki P,Alvarez F,Faundes A

    更新日期:2007-08-01 00:00:00

  • Comprehensive analysis of the use of pre-procedure ultrasound for first- and second-trimester abortion.

    abstract:BACKGROUND:The use of ultrasound (US) is common in some settings before an abortion procedure. However, its positive effect on the safety or efficacy (ability to complete abortion) of the procedure has not been established. Our aim was to determine whether the use of pre-procedure US improves safety and/or efficacy of ...

    journal_title:Contraception

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    doi:10.1016/j.contraception.2010.06.014

    authors: Kulier R,Kapp N

    更新日期:2011-01-01 00:00:00